Toxicology: Enhancing Elimination of Toxins
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Questions and Answers

Which method is used to increase the excretion of drugs/metabolites through the kidney?

  • Alkalinization of urine
  • Forced diuresis
  • Acidification of urine
  • Diuretics (correct)
  • Which substances help in promoting the excretion of weak acids by increasing their ionization in the renal tubules?

  • Salicylates, phenobarbitone, methotrexate
  • Ammonium chloride & ascorbic acid
  • Mannitol & furosemide
  • Na bicarbonate & acetazolamide (correct)
  • Which method is not effective for chemicals that are reabsorbed by renal tubules due to their low concentration in the urine?

  • Acidification of urine
  • Alkalinization of urine
  • Forced diuresis
  • Diuretics (correct)
  • Which substances can be used to alkalinize the urine and promote the excretion of weak acidic drugs?

    <p>Na bicarbonate &amp; acetazolamide</p> Signup and view all the answers

    Which method promotes the excretion of weak bases by increasing their ionization in the renal tubules?

    <p>Ammonium chloride &amp; ascorbic acid</p> Signup and view all the answers

    What is the primary reason to enhance the elimination of a toxic agent from the circulation?

    <p>To minimize the distribution of the toxic agent in body compartments</p> Signup and view all the answers

    Which type of chemicals may not be effectively eliminated through forced diuresis?

    <p>Chemicals that are not reabsorbed by renal tubules</p> Signup and view all the answers

    Which substances can be used to promote the excretion of weak acidic drugs by increasing their ionization in the renal tubules?

    <p>Na bicarbonate &amp; acetazolamide</p> Signup and view all the answers

    Which method promotes the excretion of weak bases by increasing their ionization in the renal tubules?

    <p>Acidification of urine</p> Signup and view all the answers

    What is the primary purpose of using diuretics to increase urine output in toxicology?

    <p>To enhance the excretion of drugs/metabolites through the kidney</p> Signup and view all the answers

    In toxicology, which method promotes the excretion of weak acids by increasing their ionization in the renal tubules?

    <p>Alkalinization of urine</p> Signup and view all the answers

    What is the primary purpose of using diuretics to increase urine output in toxicology?

    <p>Increasing excretion of drugs/metabolites</p> Signup and view all the answers

    Which substances can be used to promote the excretion of weak acidic drugs by increasing their ionization in the renal tubules?

    <p>Sodium bicarbonate &amp; acetazolamide</p> Signup and view all the answers

    Which method is used to increase the excretion of drugs/metabolites through the kidney?

    <p>Forced diuresis</p> Signup and view all the answers

    What type of chemicals may not be effectively eliminated through forced diuresis?

    <p>Weak bases</p> Signup and view all the answers

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