Enhancing Elimination of Toxins in Toxicology
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Questions and Answers

Which method can be used to enhance the excretion of weak acids through the kidney?

  • Acidification of urine
  • Alkalinization of urine (correct)
  • Use of diuretics
  • Forced diuresis
  • What is the primary purpose of using diuretics in enhancing elimination of toxins?

  • To increase the urine output (correct)
  • To promote excretion of weak bases
  • To alkalinize the urine
  • To enhance excretion of toxins through the liver
  • Which substance is used to alkalinize the urine for promoting the excretion of weak acidic drugs?

  • Na bicarbonate (correct)
  • Ammonium chloride
  • Ascorbic acid
  • Why isn't forced diuresis effective for chemicals that are reabsorbed by renal tubules?

    <p>Because the concentration of these chemicals in the urine is low</p> Signup and view all the answers

    Which action promotes the excretion of weak bases through the kidney by increasing their ionization?

    <p>Acidification of urine</p> Signup and view all the answers

    What is the primary consideration for enhancing elimination of a poison from the circulation?

    <p>High concentration in plasma relative to its concentration in other body compartments</p> Signup and view all the answers

    Which method promotes the excretion of weak bases through the kidney by increasing their ionization?

    <p>Acidification of urine</p> Signup and view all the answers

    What is the effect of alkalinizing the urine for promoting the excretion of weak acidic drugs?

    <p>Promotes ion trapping in renal tubules</p> Signup and view all the answers

    Why isn't forced diuresis effective for chemicals that are reabsorbed by renal tubules?

    <p>Reabsorption by renal tubules</p> Signup and view all the answers

    Which action is used to increase the urine output for enhancing elimination of toxins?

    <p>Forced diuresis with diuretics</p> Signup and view all the answers

    What is the main consideration for enhancing elimination of a poison from the circulation?

    <p>High concentration in plasma relative to other body compartments</p> Signup and view all the answers

    Which method can be used to enhance the excretion of weak acids through the kidney?

    <p>Alkalinization of urine</p> Signup and view all the answers

    Why isn't forced diuresis effective for chemicals that are reabsorbed by renal tubules?

    <p>Low concentration of these chemicals in the urine</p> Signup and view all the answers

    Which action promotes the excretion of weak bases through the kidney by increasing their ionization?

    <p>Acidification of urine</p> Signup and view all the answers

    What is the effect of alkalinizing the urine for promoting the excretion of weak acidic drugs?

    <p>Increases their ionization and promotes ion trapping in the renal tubules</p> Signup and view all the answers

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