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Questions and Answers
Which organ is primarily responsible for the synthesis of Total Cholesterol (TC) in the blood?
What percentage of Total Cholesterol (TC) does HDL-C typically constitute in the blood?
What is considered a 'high' Total Cholesterol (TC) level in adults?
Which condition is NOT listed as a secondary cause of hypercholesterolemia?
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What is the expected Total Cholesterol (TC) level range for children that is defined as 'borderline high'?
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Which factor is NOT mentioned in the document as affecting Total Cholesterol (TC) levels?
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Study Notes
Total Cholesterol (TC)
- Main source of TC in the blood: synthesis (mainly by the liver and intestine) and to a lesser extent, the diet
- TC travels in the blood as lipoprotein-cholesterol of three main forms:
- LDL-C: 60-70% of TC
- HDL-C: 20-30% of TC
- VLDL-C: 10-15% of TC
- TC value in the blood is not significantly altered following a meal, so it can be measured in a random blood sample (without fasting)
- Factors that affect TC value:
- Age: increases with age
- Sex: lower in pre-menopausal women than in men
- Race: higher in North Europeans
Interpretation of Results
In Adults
- Desirable: < 200 mg/dL
- Borderline High: 200-239 mg/dL
- High: ≥ 240 mg/dL
In Children
- Desirable: < 170 mg/dL
- Borderline High: 170-199 mg/dL
- High: ≥ 200 mg/dL
Hypercholesterolemia
- Can be primary or secondary to certain diseases
- Examples of secondary diseases:
- Nephrotic syndrome
- Hypothyroidism
- Obstructive jaundice
- Diabetes mellitus
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Description
Learn about the composition of total cholesterol in the blood, including the main sources and forms of lipoprotein-cholesterol such as LDL-C, HDL-C, and VLDL-C.
