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Questions and Answers
Which organ is primarily responsible for the synthesis of Total Cholesterol (TC) in the blood?
Which organ is primarily responsible for the synthesis of Total Cholesterol (TC) in the blood?
What percentage of Total Cholesterol (TC) does HDL-C typically constitute in the blood?
What percentage of Total Cholesterol (TC) does HDL-C typically constitute in the blood?
What is considered a 'high' Total Cholesterol (TC) level in adults?
What is considered a 'high' Total Cholesterol (TC) level in adults?
Which condition is NOT listed as a secondary cause of hypercholesterolemia?
Which condition is NOT listed as a secondary cause of hypercholesterolemia?
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What is the expected Total Cholesterol (TC) level range for children that is defined as 'borderline high'?
What is the expected Total Cholesterol (TC) level range for children that is defined as 'borderline high'?
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Which factor is NOT mentioned in the document as affecting Total Cholesterol (TC) levels?
Which factor is NOT mentioned in the document as affecting Total Cholesterol (TC) levels?
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Study Notes
Total Cholesterol (TC)
- Main source of TC in the blood: synthesis (mainly by the liver and intestine) and to a lesser extent, the diet
- TC travels in the blood as lipoprotein-cholesterol of three main forms:
- LDL-C: 60-70% of TC
- HDL-C: 20-30% of TC
- VLDL-C: 10-15% of TC
- TC value in the blood is not significantly altered following a meal, so it can be measured in a random blood sample (without fasting)
- Factors that affect TC value:
- Age: increases with age
- Sex: lower in pre-menopausal women than in men
- Race: higher in North Europeans
Interpretation of Results
In Adults
- Desirable: < 200 mg/dL
- Borderline High: 200-239 mg/dL
- High: ≥ 240 mg/dL
In Children
- Desirable: < 170 mg/dL
- Borderline High: 170-199 mg/dL
- High: ≥ 200 mg/dL
Hypercholesterolemia
- Can be primary or secondary to certain diseases
- Examples of secondary diseases:
- Nephrotic syndrome
- Hypothyroidism
- Obstructive jaundice
- Diabetes mellitus
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Description
Learn about the composition of total cholesterol in the blood, including the main sources and forms of lipoprotein-cholesterol such as LDL-C, HDL-C, and VLDL-C.
