40 Questions
What is the threshold PASI score for severe psoriasis?
PASI > 10
Which therapy is recommended for chronic plaque-type psoriasis with mild severity (BSA < 10% and PASI < 10)?
Dithranol
Which systemic therapy is NOT recommended for chronic plaque-type psoriasis with moderate severity (BSA > 10% and PASI > 10)?
Calcineurin inhibitors
Which biologic therapy is indicated for the treatment of psoriasis as per the provided text?
Adalimumab
What measures will become a part of everyday practice in assessing psoriasis severity and treatment response?
Measurement of Psoriasis Area Severity Index (PASI)
Which cells are responsible for the activation of T cells in psoriasis?
Dendritic cells
Which type of T cells are the principal 'effector' T cells in psoriatic plaques?
Th17 cells
What is the primary purpose of adalimumab in the maintenance of psoriasis remission?
Blocking inflammatory cytokines
Which subtype of psoriasis is a contraindication for biologics?
Pustular psoriasis
What is a common feature of psoriatic arthritis associated with psoriasis?
Frequent relapses
What is the main hypothesis regarding the development of psoriasis?
Psoriasis is caused by an overreaction of the immune system to a trigger
What drives inflammation and keratinocyte hyperplasia in psoriatic plaque?
Interleukin-17 (IL-17)
Which comorbidity is not commonly associated with psoriasis?
Sarcoidosis
What type of drugs are biologics used to treat in psoriasis patients?
Immune response
What initiates the activation of T cells in the skin of psoriasis patients?
An unidentified trigger
What is the principle behind sequential therapy of psoriasis using Methotrexate (MTX), Cyclosporine (CyA), and Acitretin?
To maximize initial effect and diminish long-lasting toxicity
Which therapy combines both topical and systemic treatments for psoriasis?
Combined Topical and systemic therapy
What is the mechanism of action of Methotrexate (MTX) in the treatment of psoriasis?
Interferes with purine synthesis and inhibits DNA synthesis and cell replication
Which oral systemic therapy for psoriasis is a folic acid antagonist that inhibits DNA synthesis and cell replication?
Methotrexate
Which therapy is known for its selective/targeted approach in the treatment of psoriasis?
Fumaric acid esters
Which cytokines are key in the development of Th1 and Th17 cells in psoriasis?
IL-12 and IL-23
Which of the following cells promote the formation of psoriatic skin lesions by producing cytokines such as IL-17, IL-22, IFN-g, and TNF-a?
Th1 and Th17 cells
What are the heterodimers with a common subunit that is a potential target for therapeutic intervention in psoriasis?
IL-12 and IL-23
Which type of cells are responsible for the differentiation and expansion of T cell populations of the Th1 and Th17 subtype in psoriasis?
Dendritic cells
Which cytokines are produced by Th1 and Th17 cells to promote the formation of psoriatic skin lesions?
IFN-g and IL-17
What is the first-line topical therapy for psoriasis in cases with moderate body surface area (BSA > 10%) and Psoriasis Area Severity Index (PASI) > 10?
Tazarotene
What is the most suitable topical therapy for psoriasis in sensitive areas like the face and groin?
Calcipotriene
Which topical therapy should be avoided in pregnant patients due to its unsuitability?
Tazarotene
What is the recommended combination therapy for scalp psoriasis with synergistic activity on a molecular level?
Calcipotriol + Betamethasone dipropionate cream / gel
Which topical therapy should be used with caution in children due to potential toxic effects such as nausea, vomiting, and tinnitus?
Salicylic acid
What is the recommended treatment for extensive chronic plaque psoriasis in the elderly or infirm?
Systemic therapy
What is the threshold body surface area affected (BSA) that indicates the need for systemic therapy in psoriasis?
10%
Which topical therapy is effective in the short term with a 2 point improvement on a 12 point severity scale?
Tazarotene
What is the primary consideration for the choice of topical treatment for psoriasis?
Extent and pattern of psoriasis
What is the indicated PASI score for severe psoriasis requiring systemic therapy?
>10
Which therapy should not be used during pregnancy or lactation?
Coal tar
What is a common reason for poor adherence to topical therapy in psoriasis?
Side effects
Which of the following is NOT an indication for systemic therapy of psoriasis?
>5% body surface area affected (BSA)
Which topical therapy has no scientific evidence indicating its carcinogenicity in over-the-counter products?
Coal tar
Which topical therapy is a vitamin D analogue?
Calcipotriol
This quiz covers the guidelines and algorithms for topical therapy in the treatment of psoriasis, including the use of calcineurin inhibitors, coaltar basic therapy, corticosteroids, dithranol, laser, tazarotene, vitamin D3, cyclosporine, and fumaric acid esters. It also includes evidence-based (S3) severe guidelines for the treatment of psoriasis vulgaris.
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