Podcast
Questions and Answers
What is the threshold PASI score for severe psoriasis?
What is the threshold PASI score for severe psoriasis?
Which therapy is recommended for chronic plaque-type psoriasis with mild severity (BSA < 10% and PASI < 10)?
Which therapy is recommended for chronic plaque-type psoriasis with mild severity (BSA < 10% and PASI < 10)?
Which systemic therapy is NOT recommended for chronic plaque-type psoriasis with moderate severity (BSA > 10% and PASI > 10)?
Which systemic therapy is NOT recommended for chronic plaque-type psoriasis with moderate severity (BSA > 10% and PASI > 10)?
Which biologic therapy is indicated for the treatment of psoriasis as per the provided text?
Which biologic therapy is indicated for the treatment of psoriasis as per the provided text?
Signup and view all the answers
What measures will become a part of everyday practice in assessing psoriasis severity and treatment response?
What measures will become a part of everyday practice in assessing psoriasis severity and treatment response?
Signup and view all the answers
Which cells are responsible for the activation of T cells in psoriasis?
Which cells are responsible for the activation of T cells in psoriasis?
Signup and view all the answers
Which type of T cells are the principal 'effector' T cells in psoriatic plaques?
Which type of T cells are the principal 'effector' T cells in psoriatic plaques?
Signup and view all the answers
What is the primary purpose of adalimumab in the maintenance of psoriasis remission?
What is the primary purpose of adalimumab in the maintenance of psoriasis remission?
Signup and view all the answers
Which subtype of psoriasis is a contraindication for biologics?
Which subtype of psoriasis is a contraindication for biologics?
Signup and view all the answers
What is a common feature of psoriatic arthritis associated with psoriasis?
What is a common feature of psoriatic arthritis associated with psoriasis?
Signup and view all the answers
What is the main hypothesis regarding the development of psoriasis?
What is the main hypothesis regarding the development of psoriasis?
Signup and view all the answers
What drives inflammation and keratinocyte hyperplasia in psoriatic plaque?
What drives inflammation and keratinocyte hyperplasia in psoriatic plaque?
Signup and view all the answers
Which comorbidity is not commonly associated with psoriasis?
Which comorbidity is not commonly associated with psoriasis?
Signup and view all the answers
What type of drugs are biologics used to treat in psoriasis patients?
What type of drugs are biologics used to treat in psoriasis patients?
Signup and view all the answers
What initiates the activation of T cells in the skin of psoriasis patients?
What initiates the activation of T cells in the skin of psoriasis patients?
Signup and view all the answers
What is the principle behind sequential therapy of psoriasis using Methotrexate (MTX), Cyclosporine (CyA), and Acitretin?
What is the principle behind sequential therapy of psoriasis using Methotrexate (MTX), Cyclosporine (CyA), and Acitretin?
Signup and view all the answers
Which therapy combines both topical and systemic treatments for psoriasis?
Which therapy combines both topical and systemic treatments for psoriasis?
Signup and view all the answers
What is the mechanism of action of Methotrexate (MTX) in the treatment of psoriasis?
What is the mechanism of action of Methotrexate (MTX) in the treatment of psoriasis?
Signup and view all the answers
Which oral systemic therapy for psoriasis is a folic acid antagonist that inhibits DNA synthesis and cell replication?
Which oral systemic therapy for psoriasis is a folic acid antagonist that inhibits DNA synthesis and cell replication?
Signup and view all the answers
Which therapy is known for its selective/targeted approach in the treatment of psoriasis?
Which therapy is known for its selective/targeted approach in the treatment of psoriasis?
Signup and view all the answers
Which cytokines are key in the development of Th1 and Th17 cells in psoriasis?
Which cytokines are key in the development of Th1 and Th17 cells in psoriasis?
Signup and view all the answers
Which of the following cells promote the formation of psoriatic skin lesions by producing cytokines such as IL-17, IL-22, IFN-g, and TNF-a?
Which of the following cells promote the formation of psoriatic skin lesions by producing cytokines such as IL-17, IL-22, IFN-g, and TNF-a?
Signup and view all the answers
What are the heterodimers with a common subunit that is a potential target for therapeutic intervention in psoriasis?
What are the heterodimers with a common subunit that is a potential target for therapeutic intervention in psoriasis?
Signup and view all the answers
Which type of cells are responsible for the differentiation and expansion of T cell populations of the Th1 and Th17 subtype in psoriasis?
Which type of cells are responsible for the differentiation and expansion of T cell populations of the Th1 and Th17 subtype in psoriasis?
Signup and view all the answers
Which cytokines are produced by Th1 and Th17 cells to promote the formation of psoriatic skin lesions?
Which cytokines are produced by Th1 and Th17 cells to promote the formation of psoriatic skin lesions?
Signup and view all the answers
What is the first-line topical therapy for psoriasis in cases with moderate body surface area (BSA > 10%) and Psoriasis Area Severity Index (PASI) > 10?
What is the first-line topical therapy for psoriasis in cases with moderate body surface area (BSA > 10%) and Psoriasis Area Severity Index (PASI) > 10?
Signup and view all the answers
What is the most suitable topical therapy for psoriasis in sensitive areas like the face and groin?
What is the most suitable topical therapy for psoriasis in sensitive areas like the face and groin?
Signup and view all the answers
Which topical therapy should be avoided in pregnant patients due to its unsuitability?
Which topical therapy should be avoided in pregnant patients due to its unsuitability?
Signup and view all the answers
What is the recommended combination therapy for scalp psoriasis with synergistic activity on a molecular level?
What is the recommended combination therapy for scalp psoriasis with synergistic activity on a molecular level?
Signup and view all the answers
Which topical therapy should be used with caution in children due to potential toxic effects such as nausea, vomiting, and tinnitus?
Which topical therapy should be used with caution in children due to potential toxic effects such as nausea, vomiting, and tinnitus?
Signup and view all the answers
What is the recommended treatment for extensive chronic plaque psoriasis in the elderly or infirm?
What is the recommended treatment for extensive chronic plaque psoriasis in the elderly or infirm?
Signup and view all the answers
What is the threshold body surface area affected (BSA) that indicates the need for systemic therapy in psoriasis?
What is the threshold body surface area affected (BSA) that indicates the need for systemic therapy in psoriasis?
Signup and view all the answers
Which topical therapy is effective in the short term with a 2 point improvement on a 12 point severity scale?
Which topical therapy is effective in the short term with a 2 point improvement on a 12 point severity scale?
Signup and view all the answers
What is the primary consideration for the choice of topical treatment for psoriasis?
What is the primary consideration for the choice of topical treatment for psoriasis?
Signup and view all the answers
What is the indicated PASI score for severe psoriasis requiring systemic therapy?
What is the indicated PASI score for severe psoriasis requiring systemic therapy?
Signup and view all the answers
Which therapy should not be used during pregnancy or lactation?
Which therapy should not be used during pregnancy or lactation?
Signup and view all the answers
What is a common reason for poor adherence to topical therapy in psoriasis?
What is a common reason for poor adherence to topical therapy in psoriasis?
Signup and view all the answers
Which of the following is NOT an indication for systemic therapy of psoriasis?
Which of the following is NOT an indication for systemic therapy of psoriasis?
Signup and view all the answers
Which topical therapy has no scientific evidence indicating its carcinogenicity in over-the-counter products?
Which topical therapy has no scientific evidence indicating its carcinogenicity in over-the-counter products?
Signup and view all the answers
Which topical therapy is a vitamin D analogue?
Which topical therapy is a vitamin D analogue?
Signup and view all the answers
