Topical Therapy in Psoriasis Treatment
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Topical Therapy in Psoriasis Treatment

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Questions and Answers

What is the threshold PASI score for severe psoriasis?

  • PASI > 15
  • PASI > 10 (correct)
  • PASI < 5
  • PASI 5-10

    • Which therapy is recommended for chronic plaque-type psoriasis with mild severity (BSA < 10% and PASI < 10)?

  • Dithranol (correct)
  • Cyclosporine
  • Methotrexate
  • Retinoids

    • Which systemic therapy is NOT recommended for chronic plaque-type psoriasis with moderate severity (BSA > 10% and PASI > 10)?

  • Ustekinumab
  • Efalizumab
  • Calcineurin inhibitors (correct)
  • Methotrexate

    • Which biologic therapy is indicated for the treatment of psoriasis as per the provided text?

    <p>Adalimumab</p> Signup and view all the answers

    What measures will become a part of everyday practice in assessing psoriasis severity and treatment response?

    <p>Measurement of Psoriasis Area Severity Index (PASI)</p> Signup and view all the answers

    Which cells are responsible for the activation of T cells in psoriasis?

    <p>Dendritic cells</p> Signup and view all the answers

    Which type of T cells are the principal 'effector' T cells in psoriatic plaques?

    <p>Th17 cells</p> Signup and view all the answers

    What is the primary purpose of adalimumab in the maintenance of psoriasis remission?

    <p>Blocking inflammatory cytokines</p> Signup and view all the answers

    Which subtype of psoriasis is a contraindication for biologics?

    <p>Pustular psoriasis</p> Signup and view all the answers

    What is a common feature of psoriatic arthritis associated with psoriasis?

    <p>Frequent relapses</p> Signup and view all the answers

    What is the main hypothesis regarding the development of psoriasis?

    <p>Psoriasis is caused by an overreaction of the immune system to a trigger</p> Signup and view all the answers

    What drives inflammation and keratinocyte hyperplasia in psoriatic plaque?

    <p>Interleukin-17 (IL-17)</p> Signup and view all the answers

    Which comorbidity is not commonly associated with psoriasis?

    <p>Sarcoidosis</p> Signup and view all the answers

    What type of drugs are biologics used to treat in psoriasis patients?

    <p>Immune response</p> Signup and view all the answers

    What initiates the activation of T cells in the skin of psoriasis patients?

    <p>An unidentified trigger</p> Signup and view all the answers

    What is the principle behind sequential therapy of psoriasis using Methotrexate (MTX), Cyclosporine (CyA), and Acitretin?

    <p>To maximize initial effect and diminish long-lasting toxicity</p> Signup and view all the answers

    Which therapy combines both topical and systemic treatments for psoriasis?

    <p>Combined Topical and systemic therapy</p> Signup and view all the answers

    What is the mechanism of action of Methotrexate (MTX) in the treatment of psoriasis?

    <p>Interferes with purine synthesis and inhibits DNA synthesis and cell replication</p> Signup and view all the answers

    Which oral systemic therapy for psoriasis is a folic acid antagonist that inhibits DNA synthesis and cell replication?

    <p>Methotrexate</p> Signup and view all the answers

    Which therapy is known for its selective/targeted approach in the treatment of psoriasis?

    <p>Fumaric acid esters</p> Signup and view all the answers

    Which cytokines are key in the development of Th1 and Th17 cells in psoriasis?

    <p>IL-12 and IL-23</p> Signup and view all the answers

    Which of the following cells promote the formation of psoriatic skin lesions by producing cytokines such as IL-17, IL-22, IFN-g, and TNF-a?

    <p>Th1 and Th17 cells</p> Signup and view all the answers

    What are the heterodimers with a common subunit that is a potential target for therapeutic intervention in psoriasis?

    <p>IL-12 and IL-23</p> Signup and view all the answers

    Which type of cells are responsible for the differentiation and expansion of T cell populations of the Th1 and Th17 subtype in psoriasis?

    <p>Dendritic cells</p> Signup and view all the answers

    Which cytokines are produced by Th1 and Th17 cells to promote the formation of psoriatic skin lesions?

    <p>IFN-g and IL-17</p> Signup and view all the answers

    What is the first-line topical therapy for psoriasis in cases with moderate body surface area (BSA > 10%) and Psoriasis Area Severity Index (PASI) > 10?

    <p>Tazarotene</p> Signup and view all the answers

    What is the most suitable topical therapy for psoriasis in sensitive areas like the face and groin?

    <p>Calcipotriene</p> Signup and view all the answers

    Which topical therapy should be avoided in pregnant patients due to its unsuitability?

    <p>Tazarotene</p> Signup and view all the answers

    What is the recommended combination therapy for scalp psoriasis with synergistic activity on a molecular level?

    <p>Calcipotriol + Betamethasone dipropionate cream / gel</p> Signup and view all the answers

    Which topical therapy should be used with caution in children due to potential toxic effects such as nausea, vomiting, and tinnitus?

    <p>Salicylic acid</p> Signup and view all the answers

    What is the recommended treatment for extensive chronic plaque psoriasis in the elderly or infirm?

    <p>Systemic therapy</p> Signup and view all the answers

    What is the threshold body surface area affected (BSA) that indicates the need for systemic therapy in psoriasis?

    <p>10%</p> Signup and view all the answers

    Which topical therapy is effective in the short term with a 2 point improvement on a 12 point severity scale?

    <p>Tazarotene</p> Signup and view all the answers

    What is the primary consideration for the choice of topical treatment for psoriasis?

    <p>Extent and pattern of psoriasis</p> Signup and view all the answers

    What is the indicated PASI score for severe psoriasis requiring systemic therapy?

    <p>&gt;10</p> Signup and view all the answers

    Which therapy should not be used during pregnancy or lactation?

    <p>Coal tar</p> Signup and view all the answers

    What is a common reason for poor adherence to topical therapy in psoriasis?

    <p>Side effects</p> Signup and view all the answers

    Which of the following is NOT an indication for systemic therapy of psoriasis?

    <p>&gt;5% body surface area affected (BSA)</p> Signup and view all the answers

    Which topical therapy has no scientific evidence indicating its carcinogenicity in over-the-counter products?

    <p>Coal tar</p> Signup and view all the answers

    Which topical therapy is a vitamin D analogue?

    <p>Calcipotriol</p> Signup and view all the answers

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