Psoriasis Treatment Adverse Reactions
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Questions and Answers

What is one of the primary anti-inflammatory effects mentioned?

  • Increases pro-inflammatory cytokines
  • Stimulates lymphocyte activity
  • Enhances cell proliferation
  • Decreases pro-inflammatory cytokines (correct)
  • Which cellular process is inhibited as part of the antiproliferative effect?

  • Cell apoptosis
  • Cell differentiation
  • Cell metabolism
  • Cell division (correct)
  • Which of the following best describes the overall impact on lymphocytes?

  • Enhances lymphocyte survival
  • Stimulates lymphocyte activity
  • Promotes lymphocyte growth
  • Inhibits lymphocyte proliferation (correct)
  • What role do pro-inflammatory cytokines play in inflammation?

    <p>They promote inflammatory responses.</p> Signup and view all the answers

    What is an expected outcome of decreasing mediators associated with inflammation?

    <p>Reduced inflammatory response</p> Signup and view all the answers

    What type of immune cells are primarily involved in the pathology of psoriasis?

    <p>T-lymphocytes</p> Signup and view all the answers

    Which of the following is a critical adverse reaction to psoriasis treatments?

    <p>Increased risk of infections</p> Signup and view all the answers

    Which of the following statements regarding drug interactions in psoriasis treatments is true?

    <p>Drug interactions may exacerbate adverse reactions.</p> Signup and view all the answers

    What are contraindications in the context of psoriasis treatments?

    <p>Specific situations where a drug should not be used.</p> Signup and view all the answers

    Which systemic aspect of psoriasis contributes to its classification as a systemic inflammatory disease?

    <p>T-cell mediated immune response</p> Signup and view all the answers

    What is the primary health focus of the research conducted on psoriasis patients?

    <p>Systemic inflammation and cardiovascular comorbidity</p> Signup and view all the answers

    What role does systemic inflammation play in psoriasis patients according to the study?

    <p>It is a leading cause of cardiovascular diseases.</p> Signup and view all the answers

    Why is understanding the link between psoriasis and cardiovascular issues important?

    <p>It allows for more comprehensive patient care.</p> Signup and view all the answers

    Which of the following could be a consequence of systemic inflammation in psoriasis patients?

    <p>Increased likelihood of cardiovascular events</p> Signup and view all the answers

    What might be an underlying cause of the cardiovascular comorbidities in psoriasis patients?

    <p>Chronic systemic inflammation</p> Signup and view all the answers

    Which of the following is NOT a cutaneous adverse effect associated with topical corticosteroid use?

    <p>Increased perspiration</p> Signup and view all the answers

    Which condition has been a primary focus of treatment with topical corticosteroids for over fifty years?

    <p>Psoriasis</p> Signup and view all the answers

    What is one of the consequences of extensive use of topical corticosteroids?

    <p>Folliculitis</p> Signup and view all the answers

    Which of the following adverse effects is characterized by the growth of excessive hair?

    <p>Hypertrichosis</p> Signup and view all the answers

    What skin condition involves inflammation around the mouth that may be exacerbated by topical corticosteroids?

    <p>Perioral dermatitis</p> Signup and view all the answers

    What must be avoided when using anti-TNF agents?

    <p>Concomitant use with another biological immunosuppressive agent</p> Signup and view all the answers

    Which of the following is NOT a common adverse effect of anti-TNF agents?

    <p>Lowering blood pressure</p> Signup and view all the answers

    Which condition can worsen with the use of anti-TNF agents?

    <p>Chronic heart failure</p> Signup and view all the answers

    What is a crucial precaution when using IL-23 inhibitors?

    <p>Immunization with live vaccines</p> Signup and view all the answers

    Which of the following conditions are examples of autoimmune diseases that require caution with certain medications?

    <p>Peripheral and central demyelinating disorders</p> Signup and view all the answers

    Study Notes

    Psoriasis Overview

    • Psoriasis is a systemic inflammatory disease driven by progressive T-lymphocytes.
    • Key effects of psoriasis treatments include anti-inflammatory and antiproliferative actions.

    Adverse Reactions and Side Effects

    • Common cutaneous adverse effects:
      • Skin atrophy
      • Acne
      • Contact dermatitis
      • Perioral dermatitis or folliculitis
      • Hypertrichosis
      • Hypopigmentation
    • Anti-TNF agents generally well-tolerated but carry risks:
      • Increased infection risk, including reactivation of latent tuberculosis.
      • Potential for malignancies.
      • May exacerbate chronic heart failure (CHF).

    Treatments and Interactions

    • Topical corticosteroids have been the primary treatment for psoriasis for over 50 years.
    • Caution is advised when using topical corticosteroids in patients with autoimmune diseases or demyelinating disorders.
    • Concomitant use of anti-TNF agents with other biological immunosuppressive agents is contraindicated due to drug interactions.

    Systematic Biologics and IL-23 Inhibitors

    • IL-23 inhibitors work by targeting and neutralizing IL-23, reducing inflammation.
    • Precautions include avoiding treatment in patients with active infections and against live vaccines.
    • Special caution for individuals with autoimmune diseases when using these treatments.

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    Description

    This quiz covers the critical adverse reactions and drug interactions associated with psoriasis treatments. Participants will learn about contraindications and the implications for patient care in the management of this systemic inflammatory disease.

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