Podcast
Questions and Answers
What is one of the primary anti-inflammatory effects mentioned?
What is one of the primary anti-inflammatory effects mentioned?
- Increases pro-inflammatory cytokines
- Stimulates lymphocyte activity
- Enhances cell proliferation
- Decreases pro-inflammatory cytokines (correct)
Which cellular process is inhibited as part of the antiproliferative effect?
Which cellular process is inhibited as part of the antiproliferative effect?
- Cell apoptosis
- Cell differentiation
- Cell metabolism
- Cell division (correct)
Which of the following best describes the overall impact on lymphocytes?
Which of the following best describes the overall impact on lymphocytes?
- Enhances lymphocyte survival
- Stimulates lymphocyte activity
- Promotes lymphocyte growth
- Inhibits lymphocyte proliferation (correct)
What role do pro-inflammatory cytokines play in inflammation?
What role do pro-inflammatory cytokines play in inflammation?
What is an expected outcome of decreasing mediators associated with inflammation?
What is an expected outcome of decreasing mediators associated with inflammation?
What type of immune cells are primarily involved in the pathology of psoriasis?
What type of immune cells are primarily involved in the pathology of psoriasis?
Which of the following is a critical adverse reaction to psoriasis treatments?
Which of the following is a critical adverse reaction to psoriasis treatments?
Which of the following statements regarding drug interactions in psoriasis treatments is true?
Which of the following statements regarding drug interactions in psoriasis treatments is true?
What are contraindications in the context of psoriasis treatments?
What are contraindications in the context of psoriasis treatments?
Which systemic aspect of psoriasis contributes to its classification as a systemic inflammatory disease?
Which systemic aspect of psoriasis contributes to its classification as a systemic inflammatory disease?
What is the primary health focus of the research conducted on psoriasis patients?
What is the primary health focus of the research conducted on psoriasis patients?
What role does systemic inflammation play in psoriasis patients according to the study?
What role does systemic inflammation play in psoriasis patients according to the study?
Why is understanding the link between psoriasis and cardiovascular issues important?
Why is understanding the link between psoriasis and cardiovascular issues important?
Which of the following could be a consequence of systemic inflammation in psoriasis patients?
Which of the following could be a consequence of systemic inflammation in psoriasis patients?
What might be an underlying cause of the cardiovascular comorbidities in psoriasis patients?
What might be an underlying cause of the cardiovascular comorbidities in psoriasis patients?
Which of the following is NOT a cutaneous adverse effect associated with topical corticosteroid use?
Which of the following is NOT a cutaneous adverse effect associated with topical corticosteroid use?
Which condition has been a primary focus of treatment with topical corticosteroids for over fifty years?
Which condition has been a primary focus of treatment with topical corticosteroids for over fifty years?
What is one of the consequences of extensive use of topical corticosteroids?
What is one of the consequences of extensive use of topical corticosteroids?
Which of the following adverse effects is characterized by the growth of excessive hair?
Which of the following adverse effects is characterized by the growth of excessive hair?
What skin condition involves inflammation around the mouth that may be exacerbated by topical corticosteroids?
What skin condition involves inflammation around the mouth that may be exacerbated by topical corticosteroids?
What must be avoided when using anti-TNF agents?
What must be avoided when using anti-TNF agents?
Which of the following is NOT a common adverse effect of anti-TNF agents?
Which of the following is NOT a common adverse effect of anti-TNF agents?
Which condition can worsen with the use of anti-TNF agents?
Which condition can worsen with the use of anti-TNF agents?
What is a crucial precaution when using IL-23 inhibitors?
What is a crucial precaution when using IL-23 inhibitors?
Which of the following conditions are examples of autoimmune diseases that require caution with certain medications?
Which of the following conditions are examples of autoimmune diseases that require caution with certain medications?
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Study Notes
Psoriasis Overview
- Psoriasis is a systemic inflammatory disease driven by progressive T-lymphocytes.
- Key effects of psoriasis treatments include anti-inflammatory and antiproliferative actions.
Adverse Reactions and Side Effects
- Common cutaneous adverse effects:
- Skin atrophy
- Acne
- Contact dermatitis
- Perioral dermatitis or folliculitis
- Hypertrichosis
- Hypopigmentation
- Anti-TNF agents generally well-tolerated but carry risks:
- Increased infection risk, including reactivation of latent tuberculosis.
- Potential for malignancies.
- May exacerbate chronic heart failure (CHF).
Treatments and Interactions
- Topical corticosteroids have been the primary treatment for psoriasis for over 50 years.
- Caution is advised when using topical corticosteroids in patients with autoimmune diseases or demyelinating disorders.
- Concomitant use of anti-TNF agents with other biological immunosuppressive agents is contraindicated due to drug interactions.
Systematic Biologics and IL-23 Inhibitors
- IL-23 inhibitors work by targeting and neutralizing IL-23, reducing inflammation.
- Precautions include avoiding treatment in patients with active infections and against live vaccines.
- Special caution for individuals with autoimmune diseases when using these treatments.
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