Podcast
Questions and Answers
What is the role of inflammation in tissue healing?
What is the role of inflammation in tissue healing?
Which condition is typically indicated by the suffix '-itis'?
Which condition is typically indicated by the suffix '-itis'?
What is meant by primary injury in the context of tissue healing?
What is meant by primary injury in the context of tissue healing?
What is the expected duration of bleeding referred to as hemostasis?
What is the expected duration of bleeding referred to as hemostasis?
Signup and view all the answers
In what type of tissues is the onset and resolution of inflammation swifter?
In what type of tissues is the onset and resolution of inflammation swifter?
Signup and view all the answers
Which of the following is NOT a cardinal sign of inflammation?
Which of the following is NOT a cardinal sign of inflammation?
Signup and view all the answers
What initiates the process of bleeding at an injury site?
What initiates the process of bleeding at an injury site?
Signup and view all the answers
What type of injury results in secondary injury?
What type of injury results in secondary injury?
Signup and view all the answers
What type of collagen is initially produced by fibroblasts during the healing process?
What type of collagen is initially produced by fibroblasts during the healing process?
Signup and view all the answers
What role do macrophages play in the proliferation phase of healing?
What role do macrophages play in the proliferation phase of healing?
Signup and view all the answers
How long can the remodelling phase last after an injury?
How long can the remodelling phase last after an injury?
Signup and view all the answers
Which factor is NOT listed as affecting healing?
Which factor is NOT listed as affecting healing?
Signup and view all the answers
What happens to collagen during the remodelling phase?
What happens to collagen during the remodelling phase?
Signup and view all the answers
Which statement regarding inappropriate therapy during healing is accurate?
Which statement regarding inappropriate therapy during healing is accurate?
Signup and view all the answers
What is a key factor for increasing collagen tensile strength during remodelling?
What is a key factor for increasing collagen tensile strength during remodelling?
Signup and view all the answers
What is the primary function of angiogenesis in tissue healing?
What is the primary function of angiogenesis in tissue healing?
Signup and view all the answers
What is the initial response of blood vessels during an acute injury?
What is the initial response of blood vessels during an acute injury?
Signup and view all the answers
Which chemical mediators are involved in increasing vasopermeability?
Which chemical mediators are involved in increasing vasopermeability?
Signup and view all the answers
What role do neutrophils play during the cellular events of inflammation?
What role do neutrophils play during the cellular events of inflammation?
Signup and view all the answers
What characterizes chronic inflammation?
What characterizes chronic inflammation?
Signup and view all the answers
What is the duration of the proliferation phase?
What is the duration of the proliferation phase?
Signup and view all the answers
What occurs as a result of the increased presence of plasma proteins during inflammation?
What occurs as a result of the increased presence of plasma proteins during inflammation?
Signup and view all the answers
What is fibroplasia associated with during the proliferation phase?
What is fibroplasia associated with during the proliferation phase?
Signup and view all the answers
Which statement is true regarding the chemical mediators involved in inflammation?
Which statement is true regarding the chemical mediators involved in inflammation?
Signup and view all the answers
Study Notes
Tissue Healing Phases
- Four phases of tissue healing: Bleeding, Inflammation, Proliferation, Remodelling
- Inappropriate therapy at any stage can inhibit healing.
Bleeding
- Also referred to as hemostasis
- Duration of bleeding varies depending on tissue vascularity
- Disruption of blood vessels triggers vasoconstriction, followed by vasodilation once fibrin and fibronectin form a clot.
Inflammation
- Normal and essential response to tissue damage
- Removes damaged tissues and prepares for repair
- Onset and resolution are faster in vascular tissues and slower in poorly vascular tissues
- Cardinal signs: heat, redness, swelling, pain, loss of function
- Maximal reaction 1-3 days following injury
Inflammation: Vascular Events
- Vasodilation caused by histamine and prostaglandins
- Increased vasopermeability caused by histamine and serotonin
- Leakier cell membranes result in increased volume, flow, and pressure causing fluid to pass into tissue spaces
Inflammation: Cellular Events
- Emigration of phagocytes, like neutrophils, help to protect from infection and remove tissue debris
- Lactic acid released during phagocytosis stimulates proliferation.
Chronic Inflammation
- May follow prolonged acute inflammation or develop slowly
- Characterized by production of fibrous material to aid repair
Proliferation
- Also called the regeneration phase
- Restoration of repair tissue
- Extends from 48 hours to 3-6 weeks
Proliferation: Fibroblast Formation
- Fibroblasts manufacture and maintain connective tissue (collagen)
- Fibroblasts migrate to injured area and produce new collagen to replace damaged tissue
- Initially type III collagen, with a granular structure, is produced.
Proliferation: Angiogenesis
- Creation of new blood vessels
- Capillaries bud into the area to provide oxygen and remove waste products
Remodelling
- Refinement of collagen and its extracellular matrix
- Initial collagen deposition is weak and randomly oriented
- Collagen increases in tensile strength and aligns with local stresses through exercise
- Type III collagen matures or is reabsorbed into type I collagen
- Can last up to 12 months post-injury.
Factors Affecting Healing
- Age
- Smoking
- Long-term steroid use
- NSAIDs
- Temperature (slower healing in colder temperatures)
- Poor blood supply / ischaemia
- Excessive movement or mechanical stress
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Test your knowledge on the four phases of tissue healing: Bleeding, Inflammation, Proliferation, and Remodelling. Understand the importance of appropriate therapy during these stages and the physiological responses involved, particularly during inflammation. This quiz covers the crucial aspects of tissue response to injury.
