Thyroid Gland Pathophysiology Review

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18 Questions

What is the storage form of the thyroid hormone in the thyroid gland?

Thyroglobulin

Which hormone stimulates the production and release of TSH from the pituitary gland?

TRH

Which carrier protein is the major carrier of protein for thyroid hormones?

TBG

What is the conversion product of T4?

T3

Which hormone controls the secretion of TSH in a pulsatile circadian manner?

Melatonin

What type of hormones are unbound to plasma proteins and are free to act in the body?

Active Hormones

Which hormone is synthesized in the anterior pituitary gland?

TSH

Which hormone stimulates the production and release of T4 from the thyroid gland?

TSH

What is the primary function of thyroglobulin in the synthesis of thyroid hormones?

Synthesis and storage of amino acid residues for thyroid hormones

Which thyroid hormone is the most active and four times more potent than T4?

T3

What role do thyroid hormones play in cellular enzyme activity?

Increase cellular enzyme activity

Which of the following is NOT a function of thyroid hormones?

Decrease protein synthesis

Where does primary thyroid dysfunction occur?

Thyroid gland

Which autoimmune disease causes hyperthyroidism?

Graves' disease

What is the most common cause of thyroid disease?

'It is autoimmune disease'

Which thyroid dysfunction occurs at the pituitary level?

'Secondary'

In which organ do thyroid hormones regulate proteins important in liver, cardiac, neuro, and muscle functioning?

'Liver'

'Now you see why people feel horrible when their thyroid is out of whack' implies that ___?

'Thyroid imbalances can cause negative symptoms'

Review the pathophysiology of the thyroid gland before discussing hypo/hyperthyroidism. Understand the structure of the thyroid gland follicles, the role of thyroglobulin, and the control of thyroid function by TSH.

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