Thyroid Disorders and Anatomy

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10 Questions

What is the typical location of the isthmus of the thyroid gland?

Overlies the 2nd and 3rd tracheal rings

What is the average weight of a normal thyroid gland?

15-25g

What is the function of calcitonin produced by the thyroid gland?

Regulation of calcium homeostasis

What is the importance of recognizing the intimate relationship between the thyroid gland and the recurrent laryngeal nerve?

To avoid voice change during thyroid surgery

What is the typical shape of each thyroid lobe?

Cone-shaped

What is the name of the superior extension of the thyroid gland that is present in up to 70% of cases?

Pyramidal lobe

What is the significance of a palpable thyroid gland?

It implies some degree of enlargement and pathology

What are the principal thyroid hormones produced by the thyroid gland?

Triiodothyronine (T3) and thyroxine (T4)

What is the typical location of the parathyroid glands in relation to the thyroid gland?

Intimately related to the thyroid gland

What is the precursor to the synthesis of thyroid hormones?

Iodine and tyrosine

Study Notes

Thyroid Disorders

  • Thyroid disorders are common and can present with a neck swelling or symptoms and signs of thyroid dysfunction (hypo- or hyper-thyroidism).

Thyroid Anatomy

  • The thyroid gland consists of two lateral lobes joined by the isthmus, which overlies the 2nd and 3rd tracheal rings.
  • The pyramidal lobe is a superior extension near the midline, present in up to 70% of cases.
  • Each thyroid lobe is cone-shaped, measuring approximately 5cm in length and 2-3 cm wide in its transverse and anteroposterior dimensions.
  • The thyroid gland weighs 15-25g.
  • A normal thyroid gland is not palpable, and a visible or palpable thyroid almost always implies some degree of enlargement and pathology.

Thyroid Physiology

  • The thyroid gland produces thyroid hormones, primarily triiodothyronine (T3) and thyroxine (T4), which regulate growth and function of many organ systems.
  • T3 and T4 are synthesized from iodine and tyrosine.
  • The thyroid also produces calcitonin, which plays a role in calcium homeostasis.
  • Thyroid hormone output is regulated by thyroid-stimulating hormone (TSH) produced by the anterior pituitary, which is regulated by thyrotropin-releasing hormone (TRH) produced by the hypothalamus.

Thyroid Enlargement

  • Thyroid enlargement can be symmetric (goitre) or asymmetric (solitary nodule).
  • A thyroid enlargement can be differentiated from other causes of a cervical mass by its location in the lower midline of the neck and its movement on swallowing.

Identify and manage thyroid disorders, including thyroid swelling and dysfunction. Learn to differentiate thyroid swelling from other neck masses and recognize symptoms of hypo- and hyperthyroidism.

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