5.3
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Questions and Answers

Which of the following best describes the mechanism of thyroid hormone action?

  • Inhibiting gene transcription to regulate metabolism
  • Increasing protein synthesis to stimulate cellular metabolism (correct)
  • Binding to surface receptors to stimulate adenylate cyclase
  • Stimulating the release of neurotransmitters to regulate appetite

What is the primary function of the hypothalamus in regulating thyroid function?

  • To regulate the release of thyroid hormones from the thyroid gland
  • To stimulate the synthesis of thyroglobulin
  • To secrete thyroid-stimulating hormone (TSH)
  • To produce thyrotropin-releasing hormone (TRH) to stimulate the pituitary (correct)

Which of the following are results of hyperthyroidism?

  • Increased appetite and weight loss (correct)
  • Decreased protein synthesis and muscle atrophy
  • Increased synthesis of thyroid hormones and weight gain
  • Decreased metabolic rate and weight gain

What is the primary function of the pituitary in regulating thyroid function?

<p>To release thyroid-stimulating hormone (TSH) to stimulate the thyroid gland (B)</p> Signup and view all the answers

Approximately, what is the percentage of T4 and T3 that is bound to plasma proteins?

<p>99% (B)</p> Signup and view all the answers

What is the result of the outer ring deiodination of T4?

<p>Conversion of T4 to T3 (B)</p> Signup and view all the answers

What is the primary function of thyroid hormone T3?

<p>Regulation of metabolic rate and heat production (B)</p> Signup and view all the answers

What is the result of the hydrolysis of thyroglobulin in lysosomal pathway?

<p>Production of free T4 and T3 and iodinated residues (B)</p> Signup and view all the answers

What is the function of thyroid-binding globulin?

<p>To provide a reservoir of hormones with a longer half-life (A)</p> Signup and view all the answers

What is the primary mechanism of action of T3 in the nucleus?

<p>It combines with a nuclear receptor to stimulate transcription of genes for the production of mRNAs (A)</p> Signup and view all the answers

What is the percentage of T3 and T4 that binds to thyroid-binding globulin (TBG) or transthyretin (TTR) in the plasma?

<p>More than 99.5% (C)</p> Signup and view all the answers

What is the mechanism by which T4 is converted to T3 in the cytosol?

<p>Deiodination (D)</p> Signup and view all the answers

What is the percentage of T3 that is released from the thyroid gland?

<p>Around 2-3% (C)</p> Signup and view all the answers

What is the name of the protein that T3 and T4 bind to in the plasma?

<p>Thyroid-binding globulin (TBG) and transthyretin (TTR) (A)</p> Signup and view all the answers

What is the effect of excess TSH on the thyroid gland?

<p>Hypertrophy of the thyroid gland (C)</p> Signup and view all the answers

What is the most common form of hyperthyroidism?

<p>Graves' disease (C)</p> Signup and view all the answers

What is the diagnosis of hyperthyroidism based on?

<p>Low TSH and high T3 and T4 (C)</p> Signup and view all the answers

What is the anesthetic concern in hyperthyroidism?

<p>Thyroid storm (B)</p> Signup and view all the answers

What is the preoperative management of hyperthyroidism in emergency surgery?

<p>Propylthiouracil (PTU) and beta blocker (D)</p> Signup and view all the answers

What is the potential complication of goiter during thyroid surgery?

<p>Tracheal deviation (B)</p> Signup and view all the answers

Which of the following is not essential for normal biosynthesis of thyroid hormones?

<p>Ferritin (C)</p> Signup and view all the answers

What is the effect of an increase in plasma levels of TSH alone have on metabolic rate?

<p>It has no effect on the metabolic rate (B)</p> Signup and view all the answers

In which condition is the TSH response to TRH most likely to be reduced?

<p>Hyperthyroidism due to diffuse hyperplasia of thyrotropes (A)</p> Signup and view all the answers

What is the effect of TSH injections on thyroidal uptake of iodine?

<p>It increases the uptake of iodine (A)</p> Signup and view all the answers

Which of the following hormones is least affected by an increase in plasma levels of TRH?

<p>TBG (D)</p> Signup and view all the answers

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