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Thrombolytic Agents Overview

Created by

@AltruisticSilicon

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Questions and Answers

What is the primary administration route for the treatment mentioned?

Subcutaneous injection

Topical application

Intravenous bolus (correct)

Oral administration

In which condition is the treatment mentioned primarily indicated?

Post-surgical recovery

Acute massive pulmonary embolism (correct)

Chronic venous insufficiency

Prophylaxis of deep vein thrombosis

What potential side effect is associated with the treatment referenced?

Nausea and vomiting

Headaches

Allergic reaction (correct)

Elevated blood pressure

Which of the following best describes the conditions treated by this intervention?

Used in both arterial and venous thrombosis Signup and view all the answers

What aspect of the treatment could potentially cause concerns during administration?

Risk of increased bleeding Signup and view all the answers

What is the role of Protamine in anticoagulation therapy?

It serves as an antidote for heparin. Signup and view all the answers

Which antidote is used for reversing the effects of warfarin?

Vitamin K Signup and view all the answers

Why would Protamine not be effective for reversing warfarin's effects?

It only binds to heparin. Signup and view all the answers

What is a common characteristic of both Protamine and Vitamin K?

They both serve as antidotes for anticoagulants. Signup and view all the answers

The primary function of Vitamin K in the context of anticoagulant therapy is?

To synthesize clotting factors. Signup and view all the answers

Study Notes

Thrombolytic Agents

Used for arterial and venous thrombosis
Administered as an intravenous bolus
Utilized in acute, massive pulmonary embolism
Can cause antigenicity and allergic reactions
Protamine and vitamin K are antidotes for heparin and warfarin, respectively

Thrombolytic Agents: Specifics

Alteplase:
- Considered "fibrin selective" because it rapidly activates plasminogen that is bound to fibrin
- Has the longest duration of action
Anistreplase:
- Considered "fibrin selective"
Streptokinase:
- Not considered "fibrin selective"
- One of the oldest thrombolytic agents
Tenecteplase:
- A prodrug
- Approved for use in ST segment elevation myocardial infarction
Urokinase:
- Not considered "fibrin selective"
- Has a shorter duration of action
Fondaparinux:
- Not a thrombolytic agent
- A direct Factor Xa inhibitor

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Description

This quiz covers key information about thrombolytic agents used in treating arterial and venous thrombosis. It includes specifics on various agents like Alteplase, Anistreplase, and Streptokinase, detailing their mechanisms and usage. Test your understanding of their applications and differences!