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Questions and Answers
What is the primary administration route for the treatment mentioned?
What is the primary administration route for the treatment mentioned?
- Subcutaneous injection
- Topical application
- Intravenous bolus (correct)
- Oral administration
In which condition is the treatment mentioned primarily indicated?
In which condition is the treatment mentioned primarily indicated?
- Post-surgical recovery
- Acute massive pulmonary embolism (correct)
- Chronic venous insufficiency
- Prophylaxis of deep vein thrombosis
What potential side effect is associated with the treatment referenced?
What potential side effect is associated with the treatment referenced?
- Nausea and vomiting
- Headaches
- Allergic reaction (correct)
- Elevated blood pressure
Which of the following best describes the conditions treated by this intervention?
Which of the following best describes the conditions treated by this intervention?
What aspect of the treatment could potentially cause concerns during administration?
What aspect of the treatment could potentially cause concerns during administration?
What is the role of Protamine in anticoagulation therapy?
What is the role of Protamine in anticoagulation therapy?
Which antidote is used for reversing the effects of warfarin?
Which antidote is used for reversing the effects of warfarin?
Why would Protamine not be effective for reversing warfarin's effects?
Why would Protamine not be effective for reversing warfarin's effects?
What is a common characteristic of both Protamine and Vitamin K?
What is a common characteristic of both Protamine and Vitamin K?
The primary function of Vitamin K in the context of anticoagulant therapy is?
The primary function of Vitamin K in the context of anticoagulant therapy is?
Study Notes
Thrombolytic Agents
- Used for arterial and venous thrombosis
- Administered as an intravenous bolus
- Utilized in acute, massive pulmonary embolism
- Can cause antigenicity and allergic reactions
- Protamine and vitamin K are antidotes for heparin and warfarin, respectively
Thrombolytic Agents: Specifics
- Alteplase:
- Considered "fibrin selective" because it rapidly activates plasminogen that is bound to fibrin
- Has the longest duration of action
- Anistreplase:
- Considered "fibrin selective"
- Streptokinase:
- Not considered "fibrin selective"
- One of the oldest thrombolytic agents
- Tenecteplase:
- A prodrug
- Approved for use in ST segment elevation myocardial infarction
- Urokinase:
- Not considered "fibrin selective"
- Has a shorter duration of action
- Fondaparinux:
- Not a thrombolytic agent
- A direct Factor Xa inhibitor
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Description
This quiz covers key information about thrombolytic agents used in treating arterial and venous thrombosis. It includes specifics on various agents like Alteplase, Anistreplase, and Streptokinase, detailing their mechanisms and usage. Test your understanding of their applications and differences!
