Podcast
Questions and Answers
What is the primary function of plasmin in the fibrinolytic system?
What is the primary function of plasmin in the fibrinolytic system?
What type of thrombolytic drug activates plasminogen at the site of thrombus only?
What type of thrombolytic drug activates plasminogen at the site of thrombus only?
Which of the following thrombolytic drugs is isolated from human urine?
Which of the following thrombolytic drugs is isolated from human urine?
What is the major side effect of thrombolytic drugs?
What is the major side effect of thrombolytic drugs?
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In which of the following conditions are thrombolytic drugs life-saving?
In which of the following conditions are thrombolytic drugs life-saving?
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What is the recommended time frame for administering thrombolytic drugs in cases of acute myocardial infarction?
What is the recommended time frame for administering thrombolytic drugs in cases of acute myocardial infarction?
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Which of the following thrombolytic drugs is produced by genetic engineering?
Which of the following thrombolytic drugs is produced by genetic engineering?
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What is the route of administration for thrombolytic drugs?
What is the route of administration for thrombolytic drugs?
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Study Notes
Thrombolytics and Fibrinolytics
- Agents used for lysis of recently formed clots (less than 12 hours)
Fibrinolytic System
- Liver secrets plasminogen, which binds to fibrin threads of the clot
- Plasminogen is activated by tissue plasminogen activator into plasmin
- Plasmin causes lysis of the clot
Thrombolytics and Fibrinolytics Mechanism
- Act by activating plasminogen into plasmin
Classification
- Non-fibrin selective: activate circulating plasminogen all over the body, systemic effect (e.g., Streptokinase and Urokinase)
- Fibrin selective: selectively activate plasminogen at the site of thrombus only, local effect (e.g., Recombinant tissue plasminogen activator)
Administration
- Both non-fibrin selective and fibrin selective must be administered by I.V. route
Non-Fibrin Selective Thrombolytic Drugs
- Streptokinase: protein isolated from beta hemolytic streptococci, may cause allergy and fever in some people
- Urokinase: enzyme isolated from human urine
Fibrin Selective Thrombolytic Drugs
- Recombinant tissue plasminogen activator: human proteins produced by genetic engineering (e.g., Alteplase and Reteplase)
Pharmacological Uses of Thrombolytic Drugs
- Life-saving in emergency thrombo-embolic disorders
- Deep venous thrombosis
- Severe pulmonary embolism
- Acute myocardial infarction
- Peripheral arterial thrombosis
- In cases of acute myocardial infarction, thrombolytic drugs should be given within 6 hours from thrombus formation
Side Effects of Thrombolytic Drugs
- Bleeding is the major side effect
- Risk of bleeding is high with Streptokinase and Urokinase, and low with recent recombinant tissue plasminogen activators
- Streptokinase can cause allergy, fever, and hypotension during I.V.
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Description
Quiz about thrombolytics and fibrinolytics, agents used to lyse recently formed clots, and their mechanism of action in the fibrinolytic system. Learn about plasminogen, tissue plasminogen activator, and plasmin.
