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Questions and Answers
What is the primary pathogenic mechanism in acquired TTP?
What is the primary pathogenic mechanism in acquired TTP?
- Autoantibody against ADAMTS 13 (correct)
- Deficiency of metalloprotease ADAMTS 13
- E.coli O157:H7 toxin-induced endothelial damage
- Activation of the coagulation cascade
Which of the following is NOT a characteristic feature of TTP?
Which of the following is NOT a characteristic feature of TTP?
- Thrombocytopenia
- Acute renal failure (correct)
- Fever
- Transient neurologic deficits
What is the primary pathogenic mechanism in HUS?
What is the primary pathogenic mechanism in HUS?
- Deficiency of metalloprotease ADAMTS 13
- E.coli O157:H7 toxin-induced endothelial damage (correct)
- Autoantibody against ADAMTS 13
- Activation of the coagulation cascade
Which laboratory test is typically normal in TTP and HUS?
Which laboratory test is typically normal in TTP and HUS?
What is the primary treatment for TTP?
What is the primary treatment for TTP?
Which of the following is a key difference between TTP and HUS?
Which of the following is a key difference between TTP and HUS?
What is the primary method used to diagnose von Willebrand disease?
What is the primary method used to diagnose von Willebrand disease?
What is the mechanism behind vWF-mediated platelet agglutination during the ristocetin test?
What is the mechanism behind vWF-mediated platelet agglutination during the ristocetin test?
What characterizes type IIA von Willebrand disease?
What characterizes type IIA von Willebrand disease?
What is primarily affected in hemophilia A?
What is primarily affected in hemophilia A?
In hemophilia A, what level of factor VIII activity defines severe cases?
In hemophilia A, what level of factor VIII activity defines severe cases?
What is the X-linked recessive disorder primarily caused by reduced factor VIII activity?
What is the X-linked recessive disorder primarily caused by reduced factor VIII activity?
Which of the following best describes the pathogenesis of Immune Thrombocytopenic Purpura (ITP)?
Which of the following best describes the pathogenesis of Immune Thrombocytopenic Purpura (ITP)?
Which of the following statements about splenectomy in ITP is true?
Which of the following statements about splenectomy in ITP is true?
What is a common finding in the bone marrow of patients with ITP?
What is a common finding in the bone marrow of patients with ITP?
Which of the following statements about splenomegaly in ITP is true?
Which of the following statements about splenomegaly in ITP is true?
Which of the following clinical manifestations is uncommon in ITP?
Which of the following clinical manifestations is uncommon in ITP?
Which of the following statements about the diagnosis of ITP is true?
Which of the following statements about the diagnosis of ITP is true?
What is the main consequence of widespread fibrin deposition within the microcirculation in DIC?
What is the main consequence of widespread fibrin deposition within the microcirculation in DIC?
Which of the following can trigger DIC according to the text?
Which of the following can trigger DIC according to the text?
What is the primary pathologic activation related to the depletion of elements required for hemostasis in DIC known as?
What is the primary pathologic activation related to the depletion of elements required for hemostasis in DIC known as?
What kind of anemia is associated with DIC due to RBC trauma while passing through vessels narrowed by fibrin thrombi?
What kind of anemia is associated with DIC due to RBC trauma while passing through vessels narrowed by fibrin thrombi?
Which of the following is NOT a trigger for Disseminated Intravascular Coagulation according to the text?
Which of the following is NOT a trigger for Disseminated Intravascular Coagulation according to the text?
What causes the secondary release of plasminogen activator in DIC?
What causes the secondary release of plasminogen activator in DIC?
What is the primary source of plasma von Willebrand factor (vWF)?
What is the primary source of plasma von Willebrand factor (vWF)?
What is the primary function of factor VIII in the coagulation pathway?
What is the primary function of factor VIII in the coagulation pathway?
What is the most common inherited bleeding disorder?
What is the most common inherited bleeding disorder?
What is the primary clinical manifestation of von Willebrand disease?
What is the primary clinical manifestation of von Willebrand disease?
Which subtype of von Willebrand disease is characterized by the selective loss of high-molecular-weight multimers of vWF?
Which subtype of von Willebrand disease is characterized by the selective loss of high-molecular-weight multimers of vWF?
What is the primary reason why von Willebrand disease is underrecognized?
What is the primary reason why von Willebrand disease is underrecognized?
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