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Therapeutic Drug Monitoring

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Questions and Answers

Which of the following is the purpose of Therapeutic Drug Monitoring (TDM)?

To analyze drug concentration in serum, plasma, or whole blood samples

To evaluate drug absorption and distribution

To establish maximum benefits with minimal toxic effects (correct)

To determine common routes of drug administration

Which of the following is NOT a common route of drug administration?

All (correct)

SC (subcutaneous)

Oral

IV (intravenous)

Which of the following statements about drug absorption is TRUE?

Liquids are absorbed more slowly than tablets and capsules

First-pass metabolism occurs after drugs enter the general circulation

Most drugs are absorbed inconsistently in healthy individuals

Most drugs are absorbed from the GI tract in a consistent manner in healthy individuals (correct)

Which of the following statements about drug absorption is FALSE?

Liquids are absorbed more quickly than tablets and capsules (D) Signup and view all the answers

What is the therapeutic range of a drug?

The maximum concentration of a drug that produces benefits (D) Signup and view all the answers

Which of the following disorders may affect drug-protein binding?

Kidney disease (B) Signup and view all the answers

Which type of drugs primarily bind to albumin?

Acidic drugs (C) Signup and view all the answers

Which type of drugs primarily bind to a1 -acid glycoprotein (AAG)?

Basic drugs (A) Signup and view all the answers

Which of the following statements is TRUE regarding drug monitoring assays?

TDM assays quantify total drug concentration (D) Signup and view all the answers

When is measuring the free drug level warranted?

For drugs that are highly protein bound (A) Signup and view all the answers