Therapeutic Drug Monitoring
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Questions and Answers

Which of the following is the purpose of Therapeutic Drug Monitoring (TDM)?

  • To analyze drug concentration in serum, plasma, or whole blood samples
  • To evaluate drug absorption and distribution
  • To establish maximum benefits with minimal toxic effects (correct)
  • To determine common routes of drug administration

Which of the following is NOT a common route of drug administration?

  • All (correct)
  • SC (subcutaneous)
  • Oral
  • IV (intravenous)

Which of the following statements about drug absorption is TRUE?

  • Liquids are absorbed more slowly than tablets and capsules
  • First-pass metabolism occurs after drugs enter the general circulation
  • Most drugs are absorbed inconsistently in healthy individuals
  • Most drugs are absorbed from the GI tract in a consistent manner in healthy individuals (correct)

Which of the following statements about drug absorption is FALSE?

<p>Liquids are absorbed more quickly than tablets and capsules (D)</p> Signup and view all the answers

What is the therapeutic range of a drug?

<p>The maximum concentration of a drug that produces benefits (D)</p> Signup and view all the answers

Which of the following disorders may affect drug-protein binding?

<p>Kidney disease (B)</p> Signup and view all the answers

Which type of drugs primarily bind to albumin?

<p>Acidic drugs (C)</p> Signup and view all the answers

Which type of drugs primarily bind to a1 -acid glycoprotein (AAG)?

<p>Basic drugs (A)</p> Signup and view all the answers

Which of the following statements is TRUE regarding drug monitoring assays?

<p>TDM assays quantify total drug concentration (D)</p> Signup and view all the answers

When is measuring the free drug level warranted?

<p>For drugs that are highly protein bound (A)</p> Signup and view all the answers

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