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Questions and Answers
Which discipline is NOT involved in Therapeutic Drug Monitoring (TDM)?
Which discipline is NOT involved in Therapeutic Drug Monitoring (TDM)?
- Pharmacology
- Pharmacokinetics
- Pathology (correct)
- Clinical Medicine
In which country did TDM service start in 1984?
In which country did TDM service start in 1984?
- Australia
- United States
- Malaysia (correct)
- Canada
When was TDM first introduced in clinical practice?
When was TDM first introduced in clinical practice?
- 1960s
- 1970s (correct)
- 1990s
- 1980s
What is the aim of TDM?
What is the aim of TDM?
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What are the specific indications for monitoring drug concentrations in body fluids?
What are the specific indications for monitoring drug concentrations in body fluids?
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Study Notes
Therapeutic Drug Monitoring (TDM)
- Pharmacy, Laboratory Medicine, and Clinical Pharmacology are disciplines involved in TDM.
History of TDM
- TDM service started in Australia in 1984.
- TDM was first introduced in clinical practice in 1960s.
Aim and Indications of TDM
- The aim of TDM is to optimize the therapy by maintaining a plasma concentration of drugs within a therapeutic range.
- Specific indications for monitoring drug concentrations in body fluids include:
- Drugs with a narrow therapeutic index
- Patients with severe liver or kidney impairment
- Patients receiving multiple medications
- Patients not responding to treatment as expected
- Suspected toxicity or adverse reactions
- Patients with changing renal or hepatic function
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