Therapeutic Drug Monitoring: Lithium
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Questions and Answers

What is the primary indication for lithium therapy?

  • Treatment of manic episodes of bipolar disorder (correct)
  • Prophylaxis of cluster headache
  • Augmentation of antidepressant pharmacotherapy for depression
  • Premenstrual tension
  • What is the available dosage form of lithium carbonate?

  • Injection for intravenous use
  • Tablets in strengths of 100 mg or 200 mg
  • Extended-release capsules in strengths of 300 mg or 450 mg (correct)
  • Oral solution containing 8 mEq/5mL
  • What is one of the off-label uses of lithium?

  • Prevention of Alzheimer's disease
  • Prophylaxis of cluster headache (correct)
  • Management of generalized anxiety disorder
  • Treatment of schizophrenia
  • What is the neuroprotective property that has led to the study of lithium for applications in acute head injuries and chronic neurodegenerative disorders?

    <p>Protection against oxidative stress</p> Signup and view all the answers

    What is the mechanism of action of lithium?

    <p>Competition with other cations at receptor supersensitivity and tissue blockage</p> Signup and view all the answers

    Study Notes

    Lithium Therapy

    • Primary indication for lithium therapy is the treatment of bipolar disorder.

    Dosage Forms of Lithium Carbonate

    • Lithium carbonate is available in various dosage forms, including tablets, capsules, and oral solutions.

    Off-Label Uses of Lithium

    • One of the off-label uses of lithium is as an adjunct treatment for major depressive disorder.

    Neuroprotective Properties of Lithium

    • Lithium's neuroprotective property has led to its study for applications in acute head injuries and chronic neurodegenerative disorders, such as Alzheimer's disease and Huntington's disease.

    Mechanism of Action of Lithium

    • The mechanism of action of lithium involves the modulation of neurotransmitter systems, including serotonin, dopamine, and norepinephrine.
    • Lithium also inhibits the activity of certain enzymes involved in the phosphatidylinositol signaling pathway.

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    Description

    Test your knowledge on therapeutic drug monitoring of lithium, including indications, mechanism, uses, available dosage forms, pharmacokinetics, toxicity, drug interactions, dosing, and assessments.

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