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Questions and Answers
What is the primary indication for lithium therapy?
What is the primary indication for lithium therapy?
- Treatment of manic episodes of bipolar disorder (correct)
- Prophylaxis of cluster headache
- Augmentation of antidepressant pharmacotherapy for depression
- Premenstrual tension
What is the available dosage form of lithium carbonate?
What is the available dosage form of lithium carbonate?
- Injection for intravenous use
- Tablets in strengths of 100 mg or 200 mg
- Extended-release capsules in strengths of 300 mg or 450 mg (correct)
- Oral solution containing 8 mEq/5mL
What is one of the off-label uses of lithium?
What is one of the off-label uses of lithium?
- Prevention of Alzheimer's disease
- Prophylaxis of cluster headache (correct)
- Management of generalized anxiety disorder
- Treatment of schizophrenia
What is the neuroprotective property that has led to the study of lithium for applications in acute head injuries and chronic neurodegenerative disorders?
What is the neuroprotective property that has led to the study of lithium for applications in acute head injuries and chronic neurodegenerative disorders?
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What is the mechanism of action of lithium?
What is the mechanism of action of lithium?
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Study Notes
Lithium Therapy
- Primary indication for lithium therapy is the treatment of bipolar disorder.
Dosage Forms of Lithium Carbonate
- Lithium carbonate is available in various dosage forms, including tablets, capsules, and oral solutions.
Off-Label Uses of Lithium
- One of the off-label uses of lithium is as an adjunct treatment for major depressive disorder.
Neuroprotective Properties of Lithium
- Lithium's neuroprotective property has led to its study for applications in acute head injuries and chronic neurodegenerative disorders, such as Alzheimer's disease and Huntington's disease.
Mechanism of Action of Lithium
- The mechanism of action of lithium involves the modulation of neurotransmitter systems, including serotonin, dopamine, and norepinephrine.
- Lithium also inhibits the activity of certain enzymes involved in the phosphatidylinositol signaling pathway.
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Test your knowledge on therapeutic drug monitoring of lithium, including indications, mechanism, uses, available dosage forms, pharmacokinetics, toxicity, drug interactions, dosing, and assessments.
