Therapeutic Drug Monitoring (TDM) Indications

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Questions and Answers

When is TDM needed for a patient?

When the patient is recovering well

When the patient is discharged

When non-compliance is suspected (correct)

When initiating new medications

Which situation would require TDM?

Changes in renal/liver functions (correct)

Change in diet

Change in address

Change in occupation

What is a reason to initiate TDM?

When the patient is healthy

When the patient wants to try a new medication

When toxicity or treatment failure are suspected (correct)

When the patient is experiencing severe side effects

When is TDM necessary during medication changes?

When switching from one dosage form to another Signup and view all the answers

What is not a reason to initiate TDM?

When the patient is experiencing no symptoms Signup and view all the answers

What is the primary factor that determines the concentration gradient between the systemic circulation and the site of action?

Transport processes Signup and view all the answers

What is the purpose of a loading dose?

To rapidly achieve a desired plasma concentration Signup and view all the answers

What is the relationship between clearance and the volume of distribution?

Clearance is directly proportional to the volume of distribution Signup and view all the answers

What is the half-life of a drug dependent on?

Elimination rate constant and volume of distribution Signup and view all the answers

What is the total clearance of a drug composed of?

Renal clearance and non-renal clearance Signup and view all the answers

What is the maintenance dose of a drug equal to?

The rate of elimination at steady state Signup and view all the answers

What is the term for the predictable relationship between plasma drug concentration and concentration at the receptor site?

Kinetic homogeneity Signup and view all the answers

What is the primary application of pharmacokinetic data collected during drug development and clinical trials?

Design of dosage regimens and route of administration Signup and view all the answers

What is the term for the concentration of drug in the blood that is achieved when the amount of drug administered is equal to the amount of drug eliminated in that same period of time?

Cpss Signup and view all the answers

What is the primary assumption behind pharmacokinetic modeling?

Drug concentration in the blood is in equilibrium with the drug concentration at the site of action Signup and view all the answers

What is the term for the process of converting a drug dosage regimen from one route of administration to another?

Regimen conversion Signup and view all the answers

What is the term for the relationship between the amount of drug administered and the amount of drug eliminated in a given period of time?

MD = Cl x Cp x t Signup and view all the answers

What is the primary focus of Pharmacokinetics?

The study of the absorption, distribution, metabolism, and excretion of a drug Signup and view all the answers

What does the term 'bioavailability' refer to?

The fraction of a drug that reaches the systemic circulation Signup and view all the answers

What is the term for the size of a compartment in which the total amount of a drug would need to be dissolved in order to produce the same concentration as in the plasma?

Volume of distribution Signup and view all the answers

Which of the following drugs is typically monitored using TDM due to its narrow therapeutic index?

All of the above Signup and view all the answers

What is the primary purpose of TDM?

To monitor the levels of a drug in the blood to ensure they are within the therapeutic range Signup and view all the answers

What is the significance of a drug having a bioavailability of 0.87?

Only 87% of the drug reaches the systemic circulation Signup and view all the answers

Study Notes

When you need TDM? When initiating new TDM drugs When toxicity or treatment failure are suspected When non-compliance is suspected When changing from one dosage form to another (changes in bioavailability) When there are changes in renal/ liver functions (according to the relevant drugs)

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Description

Identify when to initiate Therapeutic Drug Monitoring (TDM) to ensure safe and effective treatment. This quiz covers scenarios that require TDM, including changes in dosage forms, patient compliance, and organ function.