Mycobacteria
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Questions and Answers

Which of the following is the primary mode of transmission for Mycobacterium tuberculosis?

  • Direct contact with infected animals
  • Inhalation of droplet nuclei (correct)
  • Transmission through blood transfusion
  • Ingestion of contaminated food

What are the symptoms of primary tuberculosis infection?

  • Fever and malaise (correct)
  • Severe cough and chest pain
  • Joint pain and muscle weakness
  • Nausea and vomiting

What is the role of cell mediated immunity (CMI) in containing the infection?

  • CMI increases the contagiousness of the disease
  • CMI eliminates bacteria from distal organs (correct)
  • CMI leads to the formation of fibrosis in the lungs
  • CMI causes miliary tuberculosis

Which of the following factors correlates with increased risk of tuberculosis infection?

<p>Crowding (A)</p> Signup and view all the answers

Which of the following is associated with a disease that infiltrates in the apex of the lung on x-ray or cavitation, also called caseous necrosis, in more advanced disease?

<p>Reactivation disease (A)</p> Signup and view all the answers

What is the characteristic X-ray finding in more advanced tuberculosis disease?

<p>Infiltrates in the apex of the lung (D)</p> Signup and view all the answers

What is the term used to describe the spread of Mycobacterium tuberculosis through lymphatic drainage?

<p>Hilar lymphadenopathy (A)</p> Signup and view all the answers

What is the primary site of initial multiplication of Mycobacterium tuberculosis in the body?

<p>Alveoli (D)</p> Signup and view all the answers

What is the term used to describe the formation of thousands of foci of multiplying organisms in tuberculosis?

<p>Miliary tuberculosis (A)</p> Signup and view all the answers

What is the characteristic X-ray finding in more advanced tuberculosis disease?

<p>Cavitation (C)</p> Signup and view all the answers

What are the symptoms of primary tuberculosis infection?

<p>Enlarged hilar lymph nodes (A)</p> Signup and view all the answers

Which of the following is the primary site where dormant M. tuberculosis organisms reside in the body?

<p>noncalcified tubercles in the Lungs (A)</p> Signup and view all the answers

Which age group is more likely to develop tuberculous meningitis in developing countries?

<p>Children up to 4 years of age (B)</p> Signup and view all the answers

Which vaccine can provide protection against tuberculous meningitis in children?

<p>BCG (A)</p> Signup and view all the answers

Which type of patients are susceptible to Mycobacterium avium-intracellulare (MAC) infection?

<p>HIV patients with CD4 count below 60/mm3 (B)</p> Signup and view all the answers

What are the symptoms of MAC infection in HIV patients?

<p>Fever, night sweats, chills, weight loss (A)</p> Signup and view all the answers

How is Mycobacterium tuberculosis resistant to drying, acid, alkali, and some disinfectants?

<p>Intensely lipoidal cell walls (C)</p> Signup and view all the answers

Which stain is traditionally used to detect acid-fast bacilli (AFB)?

<p>Ziehl-Neelsen stain (B)</p> Signup and view all the answers

What is the primary mode of transmission for Mycobacterium tuberculosis?

<p>Respiratory droplets (D)</p> Signup and view all the answers

What is the characteristic property of M. tuberculosis that accounts for its acid fastness?

<p>Intensely lipoidal cell walls (B)</p> Signup and view all the answers

How long does it typically take for cultures of M. tuberculosis to grow?

<p>3 to 6 weeks or longer (B)</p> Signup and view all the answers

What temperature and duration of heating kills M. tuberculosis?

<p>30 minutes at 60°C (B)</p> Signup and view all the answers

Which Mycobacteria screening method uses a mix of fluorescent dyes and is now routinely used to street for most mycobacteria?

<p>Auramine 0 - Rhodamine stain (D)</p> Signup and view all the answers

Which cells are responsible for mediating immunity and delayed-type hypersensitivity (DTH) to M. tuberculosis?

<p>T cells (C)</p> Signup and view all the answers

Which of the following is true about delayed-type hypersensitivity (DTH) to PPD?

<p>It is positive in normal individuals with &gt;15 mm erythema and induration. (B)</p> Signup and view all the answers

Which of the following is true about anergy?

<p>It can occur in a primary infection. (C)</p> Signup and view all the answers

Which of the following is true about the transfer of immunity to M. tuberculosis?

<p>Immunity can be transferred with T cells in animal models. (B)</p> Signup and view all the answers

What is the term used to describe the absence or loss of a delayed-type hypersensitivity (DTH) response?

<p>Anergy (B)</p> Signup and view all the answers

Mycobacteria ....

<p>inhibit phagolysosomal fusion (A)</p> Signup and view all the answers

What is the characteristic X-ray finding in more advanced tuberculosis disease?

<p>Cavitation (D)</p> Signup and view all the answers

Which type of immune response is triggered by injection of PPD in individuals who have mounted a Th1 response to M. tuberculosis proteins?

<p>Th1 response (C)</p> Signup and view all the answers

What is the significance of a positive Delayed-type Hypersensitivity (DTH) reaction to PPD?

<p>It indicates current or past TB infection (C)</p> Signup and view all the answers

Which of the following is true about IL-12 and IFN-g deleted in the context of M. tuberculosis infection?

<p>Hypersusceptible to M. Tb infection (A)</p> Signup and view all the answers

Which cells are targeted by the HIV virus in the context of M. tuberculosis infection?

<p>CD4 Th1 cells (D)</p> Signup and view all the answers

What is the role of tumor necrosis factor (TNF-a) in M. tuberculosis infection?

<p>TNF-a is needed for granuloma formation and produced by macrophage (A)</p> Signup and view all the answers

What is the purpose of Interferon-g Release Assays (IGRA) in the diagnosis of M. tuberculosis infection?

<p>To detect sensitization to M. tuberculosis by measuring INF-g release (C)</p> Signup and view all the answers

What is the BCG vaccine derived from?

<p>M. bovis (D)</p> Signup and view all the answers

Which medium is used for sputum culture in the laboratory diagnosis of M. tuberculosis?

<p>Lowenstein-Jensen medium (C)</p> Signup and view all the answers

Which of the following is a recommended first-line drug for the treatment of M. tuberculosis?

<p>Rifampin and Pyrazinamide (D)</p> Signup and view all the answers

What is the term used to describe the emergence of multi-drug resistant TB, which is resistant to isoniazid and rifampin?

<p>MDR-TB (A)</p> Signup and view all the answers

Which of the following is true about the treatment of M. tuberculosis?

<p>Multiple antibiotic regimens should be used due to high rate of drug resistance development (B)</p> Signup and view all the answers

What is the term used to describe extensively drug resistant TB, which is resistant to a second line drug?

<p>XDR-TB (B)</p> Signup and view all the answers

What is the primary reason for using multiple antibiotic regimens for the treatment of M. tuberculosis?

<p>High rate of development of drug resistance (A)</p> Signup and view all the answers

Which of the following mycobacteria do not produce niacin?

<p>Other mycobacteria (D)</p> Signup and view all the answers

What are the first-line drugs recommended for a 4 drug regimen in the treatment of M. tuberculosis?

<p>Isoniazid, rifampin, pyrazinamide, and ethambutol or streptomycin (D)</p> Signup and view all the answers

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