The Scientific Method and Peptic Ulcers

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Questions and Answers

What was the initial belief about the cause of peptic ulcers?

  • Genetic factors
  • Stress and spicy foods (correct)
  • Bacteria
  • Dietary habits

Heliobacter Pylori was discovered to cause peptic ulcers through initial successful experiments.

False (B)

Who conducted the experiment involving ingestion of Heliobacter Pylori?

Marshall

Van Helmont's experiment suggested that plants grew from sources other than _____ .

<p>soil</p> Signup and view all the answers

What methodology did Marshall and Warren follow in their research on ulcers?

<p>Primary sources (B)</p> Signup and view all the answers

Match the scientist with their hypothesis:

<p>Marshall = Peptic ulcers are caused by Heliobacter Pylori Van Helmont = Plants grow from sources other than soil</p> Signup and view all the answers

Marshall's self-experiment raised no ethical concerns.

<p>False (B)</p> Signup and view all the answers

What was the significant outcome of Marshall taking antibiotics after developing an ulcer?

<p>The ulcer began to resolve itself.</p> Signup and view all the answers

What was incorrectly concluded about plant growth?

<p>Plants grow from water alone. (C)</p> Signup and view all the answers

The methodology of the investigations conducted on plant growth included a control variable.

<p>False (B)</p> Signup and view all the answers

What is the primary source of energy that drives plant growth through photosynthesis?

<p>Sunlight</p> Signup and view all the answers

Spencer's hypothesis was that microwaves could be harnessed to cook food __________.

<p>efficiently</p> Signup and view all the answers

Match the following researchers with their conclusions:

<p>Researcher on plants = Plants grow from transforming soil into bark. Spencer = Microwaves can be harnessed to heat food efficiently.</p> Signup and view all the answers

What type of data was predominantly used during the Renaissance era?

<p>Qualitative data (A)</p> Signup and view all the answers

Spencer's investigation on microwaves was considered a diligent scientific experiment.

<p>False (B)</p> Signup and view all the answers

What was the common belief about plant growth that was disproved?

<p>Plants grow from transforming soil into bark, roots and leaves.</p> Signup and view all the answers

What is the primary conclusion drawn from Doppler's experiment?

<p>Sound frequencies change relative to the stationary observer when the sound source moves. (B)</p> Signup and view all the answers

Priestley's experiments demonstrated that plants release phlogisticated air.

<p>False (B)</p> Signup and view all the answers

What was the key factor that allowed the mouse and flame to survive in Priestley's experiment?

<p>The presence of the plant.</p> Signup and view all the answers

The change in sound frequency observed by Doppler is a result of the __________ effect.

<p>Doppler</p> Signup and view all the answers

Match the following components of a scientific report with their descriptions:

<p>Abstract = Summary of key findings Method = Materials and procedures used Results = Data represented often with graphs Conclusion = Summary of results and hypothesis status</p> Signup and view all the answers

Which part of Priestley's methodology was primarily qualitative?

<p>Observation of flame and mouse behavior. (D)</p> Signup and view all the answers

Doppler hired stationary trumpeters to observe changes in sound pitch.

<p>True (A)</p> Signup and view all the answers

What is the significance of significant figures in scientific measurements?

<p>They indicate the precision of measurements.</p> Signup and view all the answers

What is the primary method that Eratosthenes used to estimate the circumference of the Earth?

<p>Observing the angles of shadows cast by objects (B)</p> Signup and view all the answers

Eratosthenes conducted multiple experiments to verify his results.

<p>False (B)</p> Signup and view all the answers

What angle did Eratosthenes measure in Alexandria?

<p>7.2°</p> Signup and view all the answers

Microwaves produce a type of heat called ___________ heat.

<p>radiant</p> Signup and view all the answers

What assumption did Eratosthenes make about how the sun's light reaches the Earth?

<p>The sun's rays fall in parallel beams. (A)</p> Signup and view all the answers

What circumference did Eratosthenes theorize for the Earth?

<p>40,000 km</p> Signup and view all the answers

What was a major limitation of Eratosthenes' methodology?

<p>He only conducted his experiment once. (A)</p> Signup and view all the answers

Match the following terms with their respective descriptions:

<p>Microwaves = Type of electromagnetic wave Eratosthenes = Calculated Earth's circumference using shadows Shadow angle = Measured to estimate distance Radiant heat = Heat exchange via electromagnetic waves</p> Signup and view all the answers

Which of the following statements about interior zeros is true?

<p>Zeros after a non-zero with a decimal are significant. (C)</p> Signup and view all the answers

Collaborative work ensures that each member has full control over their tasks.

<p>False (B)</p> Signup and view all the answers

What is a disadvantage of working independently?

<p>You are more likely to have limited knowledge as you cannot collaborate with others.</p> Signup and view all the answers

The method that involves deliberately manipulating a variable in a scientific experiment is called ______.

<p>Experimental</p> Signup and view all the answers

Match the types of research methodology with their descriptions:

<p>Quantitative Research = Numerical data analysis Qualitative Research = Descriptive analysis of non-numerical data Correlational Research = Examining the relationship between variables Mixed Methods = Combining both quantitative and qualitative approaches</p> Signup and view all the answers

What is a key advantage of working collaboratively?

<p>There is a shared workload among team members. (D)</p> Signup and view all the answers

Observational research involves interfering with the subject during an experiment.

<p>False (B)</p> Signup and view all the answers

Name one advantage of working independently.

<p>You don’t have to wait for others to conduct their research.</p> Signup and view all the answers

Flashcards

Peptic Ulcer Cause (Hypothesis)

Peptic ulcers are caused by the bacterium Helicobacter Pylori.

Scientific Method

A systematic approach to investigation, including observation, hypothesis formation, experimentation, and analysis.

Marshall's Ulcer Experiment

Marshall intentionally ingested Helicobacter Pylori to induce an ulcer, proving the bacterial nature of the illness.

Van Helmont's Experiment

Investigated the source of plant growth using a willow tree, contrasting soil weight with plant weight.

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Heliobacter Pylori

A species of bacteria that can cause peptic ulcers.

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Experimentation in Peptic Ulcers

Used to test causal relationship of Helicobacter Pylori with peptic ulcers.

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Plant Growth Source

Van Helmont's hypothesis proposed that plants do not primarily grow from the soil, but from another source.

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Ulcer Symptoms

Peptic Ulcers are sores that develop on the stomach lining, causing discomfort or pain.

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Spencer's Microwave Experiment Hypothesis

Microwaves could efficiently cook food.

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Methodological Weakness: Spencer's Experiment

Lack of formal aim, hypothesis, and controlled variables made the experiment informal.

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Primary Investigation

Direct observation or experimentation, as opposed to secondary research.

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Uncontrolled Variables (Spencer)

Factors other than microwaves that could have affected food heating.

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Control Group (missing in older experiment)

A group in an experiment that is not exposed to the treatment being tested, used for comparison.

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Serendipitous Observation

An accidental discovery made during an experiment, not the intended result.

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Qualitative Data (older experiments).

Data based on descriptions or observations; not numerical measurements.

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Conclusion of Older Experiment (plants growing).

Plants do not grow solely from transforming soil.

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Eratosthenes' method

A method to calculate the Earth's circumference using the angle of shadows cast by the sun at different locations on Earth.

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Eratosthenes' Hypothesis

Using the angle of shadows cast by the sun to calculate the Earth's circumference.

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Parallel sun rays

A fundamental assumption in Eratosthenes' calculation, assuming sunlight reaches Earth in parallel beams.

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Shadow angle measurement

Measurement of the angle of the shadow cast by a vertical stick at a specific time and location.

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Earth's circumference calculation

Determination of the Earth's perimeter using observed angles and distances between locations.

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Limitations of Eratosthenes' experiment

The experiment's single data point makes it unreliable and the lack of precise measuring tools affects accuracy.

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Radiant heat

Heat transferred in the form of electromagnetic waves; in this case, microwaves.

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Approximate Earth circumference

The calculated value of the Earth's perimeter (40,000km) that Eratosthenes found to be remarkably close to the true value of 40,075km.

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Doppler's Hypothesis

The frequency of sound waves changes depending on the relative motion of the sound source and the observer. This means the pitch of the sound will appear higher when the source is moving towards the observer and lower when it's moving away.

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Doppler's Method

Doppler used two groups of trumpeters, one stationary and one on a moving train. He observed a change in pitch as the train passed, suggesting the frequency of sound changed due to movement.

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Priestley's Hypothesis

Priestley believed that plants released a vital component of air that was necessary for combustion and respiration. He called this component 'dephlogisticated air'.

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Priestley's Experiment

Priestley placed a mouse and a candle in a sealed jar. They died quickly. Then he placed a plant in the jar with a mouse and candle. The mouse and candle remained alive, leading him to conclude that plants release a life-sustaining component of air.

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What is Phlogiston?

Phlogiston was a hypothetical substance believed to be released during combustion and respiration, causing objects to burn.

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Priestley's Conclusion

Priestley concluded that plants release a substance that is the opposite of breathing, which we now know as photosynthesis. He also debunked the phlogiston theory.

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Scientific Report Structure

A typical scientific report follows a standardized structure including an abstract, introduction, method, results, conclusion, and discussion. Each section serves a specific purpose to clearly present the research findings and analysis.

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Significant Figures (Sig Figs)

Significant figures are the meaningful digits in a measurement. They indicate the precision of the measurement and are important when performing calculations.

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Significant Zeros

Zeros that are considered part of a number's precision and contribute to its value.

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Leading Zeros

Zeros that come before the first non-zero digit in a number and are not considered significant.

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Trailing Zeros

Zeros that come after the last non-zero digit in a number. Their significance depends on the presence of a decimal point.

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Working Collaboratively

A way of working where individuals contribute to a common goal, sharing knowledge, responsibilities, and tasks.

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Quantitative Research

A research approach that uses numerical data and statistical analysis to test hypotheses and draw conclusions.

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Qualitative Research

A research approach that explores subjective experiences, perspectives, and meanings using non-numerical data such as interviews and observations.

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Experimental Research

A research method where the researcher manipulates one or more variables to observe their effects on another variable.

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Observational Research

A research approach where the researcher observes and records natural phenomena without interfering.

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Study Notes

The Scientific Method

  • Four main steps to conducting scientific experiments:
    • Make observations
    • Ask interesting questions
    • Develop testable hypotheses
    • Gather data to test predictions

Peptic Ulcers

  • Hypothesis: Peptic ulcers are caused by a bacterium called Helicobacter Pylori.
  • Method: Warren and Marshall wanted to investigate peptic ulcers.
    • They previously collected data on patients with gastrointestinal disorders. They found the bacteria in every patient with ulcers.
    • They then conducted experiments: tried to infect tissue cultures with the bacteria, no success.
    • Marshall then infected himself, experiencing ulcer development.
    • He took antibiotics and the ulcer resolved, proving the hypothesis.
  • Methodology: Used primary sources to examine the ulcers themselves.

Deviation from Scientific Method

  • Challenges to scientific beliefs: Questioned widely-held beliefs about the cause of peptic ulcers.
  • Limited successful tests: Only had one, and it was unconventional and unusual early on.
  • Ethical concerns: Ethical concerns were raised by ingesting bacteria for experimentation
  • Negative reception: The scientific community initially scorned Marshall's work.
  • Incomplete scientific procedures : Lacked rigorous controls or data collection procedures that would be considered valid by today's scientific standard.

Conclusion

  • The conclusion was that bacteria cause peptic ulcers.

Van Helmont

  • Hypothesis: Plants grow from external sources other than the soil.
  • Method: Van Helmont planted willows and precisely measured the mass of the soil and plant over five years.
  • Methodology: He carried out his own investigations. His work is considered a primary source.
  • The study concluded that the mass of the plant was related to the water he added from observations of the soil.

Spencer

  • Hypothesis: Microwaves could be used to efficiently cook food.
  • Method: Conducted informal experiments using microwaves on different foods (like popcorn and eggs)
  • Methodology: His methodology was primary and informal.
  • Deviation from scientific method: Lack of a formal hypothesis or controlled experimental variables, though he carried out experiments out of curiosity.

Eratosthenes

  • Hypothesis: Circumference of the Earth could be calculated by shadow lengths.
  • Method: Measured the shadow angle at different locations of the Earth (Syene and Alexandria). He took into account the distance between these two locations. Used proportions and calculations to produce estimates. He was able to produce a precise estimate of the radius of Earth.
  • Methodology: He conducted primary investigations to learn through experimentation

Doppler

  • Hypothesis: Sound frequencies change relative to the observer.
  • Method: He had trumpeters play on a train and noticed a change in pitch based on the movement of the train.
  • Methodology: Primary investigation.

Priestley

  • Hypothesis: Dephlogisticated air is released by green plants, and it's necessary for combustion and respiration.
  • Method: Used controlled experiments involving jars, plants, a mouse, and candle.
  • Results: The flame and mouse survived when a plant was introduced, unlike trials without a plant.
  • The plant was discovered to produce an opposite effect of respiration, which is now called photosynthesis.

Methodology Types

  • Quantitative Research: Focused on numbers and measurements.
  • Qualitative Research: Focused on observations and descriptions.
  • Correlational Research: Examines relationships between variables.
  • Mixed Methods: Utilizes both quantitative and qualitative approaches.
  • Observational: Observing subjects without interference.
  • Experimental: Manipulating variables to study their effects.
  • Descriptive: Describing what occurs, not why.

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