The Mitochondrion in Cancer
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Questions and Answers

Which of the following is a characteristic of cancer cells in relation to mitochondrial functions?

  • Cancer cells have a lower rate of mitochondrial fission
  • Cancer cells have a higher rate of mitochondrial biogenesis (correct)
  • Cancer cells have a lower rate of mitochondrial DNA replication
  • Cancer cells have a higher rate of mitochondrial fusion

    • Which of the following is a target for anticancer therapy in glycolytic tumors?

  • Sirt1 inhibitors
  • Mitochondrial fission inducers
  • Hexokinase-2 inhibitors (correct)
  • PGC1a activators

    • What is the role of dichloroacetate (DCA) in relation to mitochondrial diseases?

  • DCA stimulates mitochondrial biogenesis
  • DCA promotes mitochondrial fusion
  • DCA enhances mitochondrial DNA replication
  • DCA inhibits metabolic pathways (correct)

    • Which axis is involved in stimulating mitochondrial biogenesis?

    <p>AMPK-PGC1a axis (D)</p> Signup and view all the answers

    What is the main focus of mitochondrial-driven therapeutics?

    <p>Targeting antioxidants to mitochondria (D)</p> Signup and view all the answers

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