Questions and Answers
Which type of microbes are relatively resistant to the microbicidal mechanisms of phagocytes?
What is the effector mechanism of T cell-mediated immunity that is required to eradicate cytosolic pathogens?
What is the basis for the designation of CD8+ T lymphocytes as cytotoxic?
Which cytokine is responsible for activation of macrophages in infections and in disease states where excessive activation of CD8+ T cells may be a feature?
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Which type of T lymphocytes may function cooperatively to destroy intracellular microbes?
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What is the mechanism by which CD8+ cytotoxic T lymphocytes (CTLs) kill infected cells?
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Which type of cells can capture antigens of infected cells and tumors and present them on class I MHC molecules?
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What is required for the differentiation of naive CD8+ T cells into functional CTLs and memory cells?
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Which molecules on the surface of infected cells do CD8+ CTLs recognize?
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What is the main mechanism by which CTLs kill target cells?
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