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What is the role of glutamate decarboxylase in determining neuron function?
What is the role of glutamate decarboxylase in determining neuron function?
Glutamate decarboxylase determines whether neurons are primarily excitatory or inhibitory.
Welche Art von Substanzen wirkt auf das GABAerge System und kann sowohl Angst als auch Schlaf verbessern?
Welche Art von Substanzen wirkt auf das GABAerge System und kann sowohl Angst als auch Schlaf verbessern?
Sind Anxiolyse und Sedation immer miteinander verbunden?
Sind Anxiolyse und Sedation immer miteinander verbunden?
What is the function of the Vesicular inhibitory amino acid transporter (VIAAT)?
What is the function of the Vesicular inhibitory amino acid transporter (VIAAT)?
What is the mechanism by which tiagabine works as an antiepileptic drug?
What is the mechanism by which tiagabine works as an antiepileptic drug?
Was sind die wichtigsten Vertreter der Wirkstoffe, die Angst und Spannungszustände lösen und den Schlaf verbessern?
Was sind die wichtigsten Vertreter der Wirkstoffe, die Angst und Spannungszustände lösen und den Schlaf verbessern?
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Study Notes
- Glutamate can be converted to GABA via decarboxylation
- Glutamate decarboxylase determines if neurons are primarily excitatory or inhibitory
- GABA transporters bring GABA into and out of cells
- Vesicular inhibitory amino acid transporter (VIAAT) helps transport GABA into vesicles
- GABA can be released via Ca2+ dependent exocytosis
- Prasynaptic GABAB receptors can control GABA release
- Strong activation of GABAB receptors can lead to loss of inhibitory neurotransmission and seizures
- Prasynaptic GABAA receptors are also present
- GABAergic tone can be increased by inhibiting GABA transaminase
- Tiagabine is an antiepileptic drug that blocks GABA transporters.
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