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Questions and Answers
What is the role of Fas ligand in triggering the extrinsic pathway of apoptosis?
What is the role of Fas ligand in triggering the extrinsic pathway of apoptosis?
- It upregulates the expression of death receptors Fas and DR5
- It activates downstream executioner caspases directly
- It binds to Fas on the target cell, leading to the formation of a death-inducing signaling complex (correct)
- It competes with death receptors for ligand binding, inhibiting apoptosis
What is the function of FLIP in the extrinsic pathway of apoptosis?
What is the function of FLIP in the extrinsic pathway of apoptosis?
- It competes with caspase 8 and caspase 10 for binding site in the DISC (correct)
- It inhibits the binding of Fas ligand to Fas receptors
- It upregulates the expression of death receptors Fas and DR5
- It directly activates downstream executioner caspases
How does the extrinsic pathway recruit the intrinsic apoptotic pathway?
How does the extrinsic pathway recruit the intrinsic apoptotic pathway?
- To amplify the caspase cascade and induce apoptosis (correct)
- To inhibit the formation of the death-inducing signaling complex
- To directly activate initiator caspases
- To compete with death receptors for ligand binding
What is the role of decoy receptors in the extrinsic pathway of apoptosis?
What is the role of decoy receptors in the extrinsic pathway of apoptosis?
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What is the function of the death-inducing signaling complex (DISC) in the extrinsic pathway of apoptosis?
What is the function of the death-inducing signaling complex (DISC) in the extrinsic pathway of apoptosis?
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