The Development of Autoimmunity

• Environmental stimuli do not cause cell and tissue injury and inflammation.
• Susceptibility genes and environmental triggers are the principal factors in the development of autoimmunity. (correct)
• Susceptibility genes do not play a role in the development of autoimmunity.
• Autoimmune diseases are caused solely by environmental triggers.

• They are responsible for autoimmune diseases.
• They cause cell and tissue injury and inflammation.
• They lead to the persistence of self-reactive T and B lymphocytes. (correct)
• They generate effector T cells and autoantibodies.

• The self antigens that induce autoimmune reactions are well-known.
• Autoimmune diseases in humans are usually heterogeneous and multifactorial. (correct)
• Autoimmune diseases in humans are usually homogeneous and monofactorial.
• Autoimmune diseases manifest clinically soon after the autoimmune reactions have been initiated.