The Development of Autoimmunity
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Questions and Answers

Which of the following is true regarding the development of autoimmunity?

  • Environmental stimuli do not cause cell and tissue injury and inflammation.
  • Susceptibility genes and environmental triggers are the principal factors in the development of autoimmunity. (correct)
  • Susceptibility genes do not play a role in the development of autoimmunity.
  • Autoimmune diseases are caused solely by environmental triggers.

    • What is the role of susceptibility genes in the development of autoimmunity?

  • They are responsible for autoimmune diseases.
  • They cause cell and tissue injury and inflammation.
  • They lead to the persistence of self-reactive T and B lymphocytes. (correct)
  • They generate effector T cells and autoantibodies.

    • Why is the etiology of common human autoimmune diseases not well understood?

  • The self antigens that induce autoimmune reactions are well-known.
  • Autoimmune diseases in humans are usually heterogeneous and multifactorial. (correct)
  • Autoimmune diseases in humans are usually homogeneous and monofactorial.
  • Autoimmune diseases manifest clinically soon after the autoimmune reactions have been initiated.

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