The Development of Autoimmunity

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Which of the following is true regarding the development of autoimmunity?

Susceptibility genes and environmental triggers are the principal factors in the development of autoimmunity.

What is the role of susceptibility genes in the development of autoimmunity?

They lead to the persistence of self-reactive T and B lymphocytes.

Why is the etiology of common human autoimmune diseases not well understood?

Autoimmune diseases in humans are usually heterogeneous and multifactorial.

Quiz: Understanding the Development of Autoimmunity Test your knowledge of the principal factors involved in the development of autoimmunity. Explore the role of susceptibility genes and environmental triggers such as infections in disrupting self-tolerance pathways. Learn how these factors contribute to the persistence of self-reactive T and B lymphocytes, leading to cell and tissue injury, inflammation, and activation.

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