L! SAQ The Antitoxins and Synthetic Drugs Quiz
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Questions and Answers

Which of the following is NOT a factor considered in drug classification?

  • Chemical structure
  • Response produced
  • Source of the drug (correct)
  • Mechanism of action

    • What is the official generic name for the drug with the chemical name 'methyl({3-phenyl-3-[4(trifluoromethyl)phenoxy]propyl})amine'?

  • Fluoxetine (hydrochloride) (correct)
  • Molecular Formula: C17H19ClF3NO
  • Prozac
  • Molecular Weight: 345.79

    • Which of the following is NOT a source of drugs?

  • Synthetic products of genetic engineering (correct)
  • Microorganisms
  • Plants
  • Animals

    • Which drug was purified from opium in 1805?

    <p>Morphine</p> Signup and view all the answers

    What was the first antibiotic discovered?

    <p>Penicillin</p> Signup and view all the answers

    Which of the following is NOT a target of chemotherapy drugs?

    <p>Receptors</p> Signup and view all the answers

    What is the mechanism of action of amitriptyline?

    <p>Inhibition of neuronal reuptake of noradrenaline and serotonin</p> Signup and view all the answers

    Which of the following affects drug-receptor binding?

    <p>All of the above</p> Signup and view all the answers

    What is the main type of bond involved in drug-receptor interactions?

    <p>Van der Waals</p> Signup and view all the answers

    What is affinity?

    <p>The strength of the reversible interaction between a drug and its receptor</p> Signup and view all the answers

    Which of the following is the correct definition of pharmacology?

    <p>The study of the effect of drugs on the function of living systems</p> Signup and view all the answers

    What is the definition of a drug according to Rang and Dale's Pharmacology?

    <p>A chemical substance of known structure, other than a nutrient or essential dietary ingredient, which, when administered to a living organism, produces a biological effect</p> Signup and view all the answers

    What are drug targets?

    <p>Proteins</p> Signup and view all the answers

    How are drug effects measured?

    <p>Dose response</p> Signup and view all the answers

    What is the nature of drug interactions?

    <p>Full</p> Signup and view all the answers

    Which of the following is the correct equation for the equilibrium constant (Kd) in the context of drug-receptor binding?

    <p>Kd = K-1 / K+1</p> Signup and view all the answers

    What does Bmax represent in the drug-receptor occupancy curve?

    <p>The density of receptors at maximum binding</p> Signup and view all the answers

    Which of the following is a correct classification of receptors based on their mechanism of activation?

    <p>Ion channels, G-protein coupled receptors, Kinase-linked receptors, Nuclear receptors</p> Signup and view all the answers

    What is the association rate constant (K+1) in the context of drug-receptor binding?

    <p>The rate at which the drug binds to the receptor</p> Signup and view all the answers

    What is the dissociation rate constant (K-1) in the context of drug-receptor binding?

    <p>The rate at which the drug-receptor complex dissociates</p> Signup and view all the answers

    Which of the following is a characteristic of G-protein coupled receptors (GPCRs)?

    <p>They are single-membrane spanning proteins.</p> Signup and view all the answers

    What is the role of GDP in G-protein coupled receptor (GPCR) activation?

    <p>It is bound to the G-protein when it is inactive.</p> Signup and view all the answers

    Which type of receptor is linked to an enzyme and adds or removes phosphate groups to specific amino acid residues?

    <p>Kinase-linked receptor</p> Signup and view all the answers

    What is the effect of insulin binding to its receptor?

    <p>Promotes uptake of glucose from blood into cells for storage.</p> Signup and view all the answers

    Which type of receptor affects DNA and alters gene transcription?

    <p>Nuclear receptor</p> Signup and view all the answers

    Which type of receptor requires lipid soluble ligands to penetrate the membrane?

    <p>Nuclear receptor</p> Signup and view all the answers

    What is the main function of steroid receptors?

    <p>Inhibit transcription of specific genes.</p> Signup and view all the answers

    Which of the following is NOT a superfamily of receptors?

    <p>Nuclear receptors</p> Signup and view all the answers

    Which of the following is a characteristic of kinase-linked receptors?

    <p>They are linked to enzymes.</p> Signup and view all the answers

    Which of the following is a characteristic of nuclear receptors?

    <p>They migrate to the nucleus when ligand binds.</p> Signup and view all the answers

    Which of the following is NOT one of the 4 receptor superfamilies mentioned in the text?

    <p>Steroid receptors</p> Signup and view all the answers

    Which type of ion channels are important in neurotransmission, cardiac conduction, muscle contraction, and secretion?

    <p>Both voltage-gated and ligand-gated ion channels</p> Signup and view all the answers

    Which type of ion channels open when the cell membrane is depolarized?

    <p>Voltage-gated ion channels</p> Signup and view all the answers

    Which type of ion channels are blocked by local anesthetics?

    <p>Voltage-gated ion channels</p> Signup and view all the answers

    Which type of receptors are also called ionotropic receptors?

    <p>Ion channels</p> Signup and view all the answers

    Which type of receptors are activated by binding of a chemical ligand to a site on the channel molecule?

    <p>G-protein-coupled receptors</p> Signup and view all the answers

    Which type of receptors are activated by the binding of glutamate, acetylcholine (nicotinic), GABA, and ATP?

    <p>G-protein-coupled receptors</p> Signup and view all the answers

    Which type of receptors are activated by nicotine and cause enhanced neurotransmitter release in the CNS?

    <p>G-protein-coupled receptors</p> Signup and view all the answers

    Which class of receptors is the most abundant and composed of seven transmembrane helices?

    <p>G-protein-coupled receptors</p> Signup and view all the answers

    Which class of receptors activate the production of second messengers such as cAMP, DAG, and IP3?

    <p>G-protein-coupled receptors</p> Signup and view all the answers

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