DSE DDVA LAYOUT-TD 061024.pdf

LOOK CLOSER TO SEE WHAT THALASSEMIA IS HIDING 1 TD PATIENTS WITH β-THALASSEMIA SERIOUS COMPLICATIONS RELATED TO TRANSFUSION AND DISEASE CAN LEAD TO END-ORGAN DAMAGE1​...

LOOK CLOSER TO SEE WHAT THALASSEMIA IS HIDING 1 TD PATIENTS WITH β-THALASSEMIA SERIOUS COMPLICATIONS RELATED TO TRANSFUSION AND DISEASE CAN LEAD TO END-ORGAN DAMAGE1​ Rates of TD complications over 10 years (all ages)​ In the 10-year follow-up period:​ 7  6% of patients had developed at least 1 comorbidity ​ I n the 45- to 49-year age group, cardiac disease occurred in 64% of patients, with the most common conditions being atrial fibrillation, heart failure, and acute arrhythmia Study design: Retrospective analysis using ICD-10 diagnosis codes in the Hospital Episode Statistics database (admissions and outpatient attendance) at National Health Service hospitals in England. Comorbidities and mortality in 612 TD (at least 8 blood transfusions) patients with β-thalassemia were recorded. ​ Patients were followed from their first hospital admission or outpatient appointment in 2009 until death in hospital, last hospital admission, or last outpatient appointment in 2018. ​ While there are limited studies in TD patients with α-thalassemia, patients with α-thalassemia may experience complications similar to those of patients with β-thalassemia. ​ Reference: 1. ​Jobanputra M, Paramore C, Laird SG, McGahan M, Telfer P. Co-morbidities and mortality associated with transfusion-dependent β-thalassaemia in patients in England: a 10-year retrospective cohort analysis. Br J Haematol. 2020;191(5):897-905. doi:10.1111/bjh.17091 1 TD PATIENTS WITH β-THALASSEMIA GREATER TRANSFUSION BURDEN IS GENERALLY ASSOCIATED WITH MORE COMPLICATIONS1 ​ Complications by average 12-week red blood cell (RBC) unit categories during follow-up Patients were grouped into transfusion burden severity cohorts based on average number of RBC units per 12 weeks during follow-up: 0 RBC units, >0 to