10 Questions
What percentage of patients with β-thalassemia developed at least one comorbidity over the 10-year follow-up period?
6%
What was the age group in which cardiac disease occurred in 64% of patients?
45-49 years
What was the most common cardiac condition in patients with β-thalassemia?
Atrial fibrillation
What was the source of data for the retrospective analysis?
National Health Service hospitals in England
How many patients with β-thalassemia were included in the study?
612
What was the time period for patient follow-up in the study?
10 years
What type of thalassemia may experience similar complications to β-thalassemia?
α-thalassemia
What was the reference for the study?
British Journal of Haematology
What serious complications can lead to end-organ damage in patients with β-thalassemia?
Transfusion and disease
What was the minimum number of blood transfusions required for patient inclusion in the study?
8
Study Notes
Transfusion-Dependent (TD) Patients with β-Thalassemia
- TD patients with β-thalassemia are at risk of developing serious complications related to transfusion and disease, which can lead to end-organ damage.
- Over 10 years, 7% of patients developed at least one comorbidity.
Comorbidities in TD Patients with β-Thalassemia
- In the 45- to 49-year age group, cardiac disease occurred in 64% of patients.
- The most common cardiac conditions were atrial fibrillation, heart failure, and acute arrhythmia.
Study Design
- The study was a retrospective analysis using ICD-10 diagnosis codes in the Hospital Episode Statistics database.
- The database included admissions and outpatient attendance at National Health Service hospitals in England.
- The study recorded comorbidities and mortality in 612 TD patients with β-thalassemia.
Study Duration and Patient Follow-up
- Patients were followed from their first hospital admission or outpatient appointment in 2009.
- The follow-up period ended at death in hospital, last hospital admission, or last outpatient appointment in 2018.
α-Thalassemia Complications
- Patients with α-thalassemia may experience complications similar to those of patients with β-thalassemia.
- However, there are limited studies in TD patients with α-thalassemia.
This quiz explores the serious complications related to transfusion and disease in patients with β-thalassemia, leading to end-organ damage. Learn about the rates of complications over 10 years and the comorbidities that develop.
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