Th1 Subset and Phagocyte-Mediated Killing
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Questions and Answers

Which type of cells primarily activate Th1 subset?

  • Neutrophils
  • Dendritic cells
  • Macrophages (correct)
  • B cells

    • What is the signature cytokine of Th1 cells?

  • Interleukin-10 (IL-10)
  • Interferon-γ (IFN-γ) (correct)
  • Interleukin-4 (IL-4)
  • Tumor necrosis factor-alpha (TNF-α)

    • What is the role of Th1 cells in the immune response?

  • Induce apoptosis in infected cells
  • Promote antibody production by B cells
  • Activate natural killer (NK) cells
  • Enhance the ability of macrophages to kill ingested microbes (correct)

    • Which type of macrophage activation is mediated by CD40L and IFN-γ?

    <p>Classical macrophage activation</p> Signup and view all the answers

    What is the function of Th1 cells?

    <p>Activate macrophages to kill phagocytosed microbes</p> Signup and view all the answers

    What is the role of IFN-γ in defense against intracellular microbes?

    <p>Contribute to macrophage activation and killing of ingested microbes</p> Signup and view all the answers

    What is the reaction called when a microbial protein is injected into the skin of an individual who has been immunized with the protein or previously infected with the microbe?

    <p>Delayed-type hypersensitivity (DTH)</p> Signup and view all the answers

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