Tetracyclines in Veterinary Medicine

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What is the parent structure of 1st generation Ceph?

7-aminopenicillanic acid

6-aminopenicillanic acid

6-aminocephalosporanic acid

7-aminocephalosporanic acid (correct)

What is the result of replacing sulfur with oxygen in a cephalosporin?

Increased antibacterial activity due to enhanced acylation power (correct)

No significant effect on antibacterial activity or chemical stability

Increased antibacterial activity and better chemical stability

Better chemical stability and longer half-life

Which generation of cephalosporins is most active against gram-positive bacteria?

1st generation (correct)

4th generation

3rd generation

5th generation

Which aminoglycoside has streptidine as its aminocyclitol ring?

Streptomycin Signup and view all the answers

What is the result of replacing sulfur with methylene in a cephalosporin?

Better chemical stability and longer half-life Signup and view all the answers

Which aminoglycoside is most ototoxic?

Streptomycin Signup and view all the answers

What is the class of antibiotics that includes Erythromycin, Azithromycin, and Clarithromycin?

Macrolides Signup and view all the answers

Which antibiotic is stable in acid due to a methyl substituent, blocking internal dehydration?

Azithromycin Signup and view all the answers

What is Bleomycin?

A mixture of cytotoxic glycopeptidase-derived antibiotics Signup and view all the answers

Which of the following is NOT a type of Penicillin?

Erythromycin Signup and view all the answers

What is the characteristic structure of Macrolides?

Macrocyclic Lactone Ring Signup and view all the answers

Which of the following antibiotics is NOT a type of Cell Wall Synthesis Inhibitor?

Aminoglycosides Signup and view all the answers

What is the primary difference between 1st and 2nd generation Tetracyclines?

Lipophilicity Signup and view all the answers

Which generation of Tetracyclines is known for its broader antibacterial spectrum?

3rd generation Signup and view all the answers

What is the name of the 3rd generation Tetracycline that is only available in IV formulation and has an increased risk of mortality?

Tigecycline Signup and view all the answers

What type of drugs are Sulfonamides?

Prodrugs Signup and view all the answers

What is the optimum substituent at N-1 for Quinolones?

Ethyl Signup and view all the answers

Which Quinolone has a methoxy substituent at C-8 and is active against gram+ bacteria?

Moxifloxacin Signup and view all the answers

What is the primary use of Tetracyclines in swine?

All of the above Signup and view all the answers

What is the name of the Tetracycline that is known to cause ototoxicity/vestibular problems?

Minocycline Signup and view all the answers