Tetanus Pathogenesis and Pathogenicity
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Questions and Answers

What is the incubation period for tetanus?

6-14 days

What is the characteristic onset of tetanus?

Persistent tonic muscular spasms at the site of penetration of the causative agent

What muscles are affected by the tonic spasms in tetanus?

Jaw muscles (trismus), face muscles (risus sardonicus), and extremities

What position does the patient assume in tetanus?

<p>The patient lies in bed, resting on his head and hips with body bent forward like an arch (opistotonus)</p> Signup and view all the answers

What is the death rate for tetanus?

<p>35-70%</p> Signup and view all the answers

What are the common sources of tetanus infection?

<p>Healthy people and animals discharging the organism in their faeces into the soil</p> Signup and view all the answers

What are the two exotoxins produced by C. tetani when they multiply in a wound?

<p>Tetanospasmin, Tetanolysin</p> Signup and view all the answers

What is the function of Tetanospasmin?

<p>Functional blockator, neurotoxin</p> Signup and view all the answers

Why is Tetanospasmin not dangerous if given orally?

<p>It can't be absorbed by the gastrointestinal mucous membrane</p> Signup and view all the answers

How does Tetanospasmin reach the motor centres of the spinal cord?

<p>Via the peripheral nerves (it moves along the axial nerve cylinders)</p> Signup and view all the answers

What specifically and avidly fixes the tetanus toxin in the nervous tissue?

<p>Gangliosides of the grey matter</p> Signup and view all the answers

What does the abolition of spinal inhibition by the tetanus toxin cause?

<p>Uncontrolled spread of impulses initiated anywhere in the central nervous system</p> Signup and view all the answers

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