Tetanus Pathogenesis and Clinical Features

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18 Questions

What is a characteristic grimace of risus sardonicus in generalized tetanus?

Frowning face with clenched teeth and wrinkled forehead

What is a potential complication of generalized tetanus?

Fracture of vertebral and long bones

What is a characteristic of tetanospasms in generalized tetanus?

Intermittent, irregular, and unpredictable

What is a common mode of infection in neonatal tetanus?

Through an unhealed umbilical stump

What is a characteristic symptom of neonatal tetanus?

Generalized weakness, poor sucking, and irritability

What is the typical duration of spasms in generalized tetanus?

Several minutes to hours

What is the estimated number of deaths worldwide in 1998 due to Tetanus?

Over 215,000

Which of the following is a complication of Tetanus related to respiratory muscles?

Laryngospasm

What is a common secondary infection seen in Tetanus patients in hospitals?

Hospital-acquired pneumonia

In what type of climate is Tetanus most often found?

Hot and damp climates

Which one of the following is a common complication of Tetanus in newborn infants with passive immunity?

Generalized tetanus

How is Tetanus primarily transmitted?

Through contaminated wounds

What is the primary mechanism by which tetanus toxin leads to muscle spasms?

By blocking the release of inhibitor neurotransmitters

What is the typical duration of spasms in generalized tetanus?

3-4 weeks

What is the correlation between the injury site and the incubation period?

The further the injury site from the CNS, the longer the incubation period

What is the average time of symptom onset in neonatal tetanus?

7 days after birth

What is a characteristic feature of local tetanus?

Fixed muscle rigidity confined to one area

What is the typical progression of cephalic tetanus?

It may precede the onset of generalized tetanus

Learn about the pathogenesis and clinical features of tetanus, including the incubation period, different clinical forms, and symptoms like trismus and difficulty swallowing. Understand how anaerobic conditions allow spores to germinate, leading to toxin production that affects the central nervous system.

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