Podcast
Questions and Answers
Which type of hypersensitivity is not mediated by antibodies?
Which type of hypersensitivity is not mediated by antibodies?
- Type III
- Type I
- Type II
- Type IV (correct)
Which cells are responsible for much of the tissue damage in Hypersensitivity type IV?
Which cells are responsible for much of the tissue damage in Hypersensitivity type IV?
- B cells
- T cells
- Eosinophils
- activated Macrophages by which are activated by cytokines by TH1 cells (correct)
This type of hypersensitivity involves the introduction of antigen into the skin and phagocytosis by local antigen presenting cells (APCs).
This type of hypersensitivity involves the introduction of antigen into the skin and phagocytosis by local antigen presenting cells (APCs).
- Type 1
- Type 2 (cytotoxic)
- Type 3 hypersensitivities
- type IV hypersensitivities (correct)
Which subcategory of type IV hypersensitivity is associated with chronic asthma and allergic rhinitis? (*hint there are 4 subcategories)
Which subcategory of type IV hypersensitivity is associated with chronic asthma and allergic rhinitis? (*hint there are 4 subcategories)
What is the first step in CD8 CTL-mediated reactions(associated with tissue transplant rejection and contact dermatitis)? also is a subcategory of hypersensitivities IV ( 3 sub cat)
What is the first step in CD8 CTL-mediated reactions(associated with tissue transplant rejection and contact dermatitis)? also is a subcategory of hypersensitivities IV ( 3 sub cat)
Which cells are targeted and induced to undergo apoptosis in CD8 CTL-mediated reactions?
Which cells are targeted and induced to undergo apoptosis in CD8 CTL-mediated reactions?
What is an example of TH1-mediated hypersensitivity?
What is an example of TH1-mediated hypersensitivity?
In this subcategory of type IV Hypersensitivities, the soluble antigen is first inhaled, resulting in eosinophil recruitment and activation with the release of cytokines and inflammatory mediators.
In this subcategory of type IV Hypersensitivities, the soluble antigen is first inhaled, resulting in eosinophil recruitment and activation with the release of cytokines and inflammatory mediators.
What is the role of activated TH1 cells in CD8 CTL-mediated reactions?
What is the role of activated TH1 cells in CD8 CTL-mediated reactions?
What subcategory of hypersensitivities type IV is also known as delayed-type hypersensitivities
What subcategory of hypersensitivities type IV is also known as delayed-type hypersensitivities
What is an example of CD8 CTL-mediated hypersensitivity?
What is an example of CD8 CTL-mediated hypersensitivity?
What is the role of antigen presenting cells in CD8 CTL-mediated reactions?
What is the role of antigen presenting cells in CD8 CTL-mediated reactions?
Which type of hypersensitivity is not mediated by antibodies?
Which type of hypersensitivity is not mediated by antibodies?
Which cells are responsible for much of the tissue damage in delayed-type hypersensitivities?remember( Type IV hypersensitivity reactions are T-cell–mediated reactions)
Which cells are responsible for much of the tissue damage in delayed-type hypersensitivities?remember( Type IV hypersensitivity reactions are T-cell–mediated reactions)
What is the sensitization step in delayed-type hypersensitivities?
What is the sensitization step in delayed-type hypersensitivities?
Which subcategory of type IV hypersensitivity is associated with chronic asthma and allergic rhinitis?
Which subcategory of type IV hypersensitivity is associated with chronic asthma and allergic rhinitis?
What is the first step in CD8 CTL-mediated reactions?
What is the first step in CD8 CTL-mediated reactions?
Which cells are targeted and induced to undergo apoptosis in CD8 CTL-mediated reactions?
Which cells are targeted and induced to undergo apoptosis in CD8 CTL-mediated reactions?
What is an example of TH1-mediated hypersensitivity?
What is an example of TH1-mediated hypersensitivity?
What type of cells are responsible for the release of cytokines and inflammatory mediators in CD4 TH2-mediated reactions?
What type of cells are responsible for the release of cytokines and inflammatory mediators in CD4 TH2-mediated reactions?
What is the role of activated TH1 cells in CD8 CTL-mediated reactions?
What is the role of activated TH1 cells in CD8 CTL-mediated reactions?
What is the second step in delayed-type hypersensitivities?
What is the second step in delayed-type hypersensitivities?
What is an example of CD8 CTL-mediated hypersensitivity?
What is an example of CD8 CTL-mediated hypersensitivity?
What is the role of antigen presenting cells in CD8 CTL-mediated reactions?
What is the role of antigen presenting cells in CD8 CTL-mediated reactions?
What is the main difference between type IV hypersensitivity and the other three types of hypersensitivity?
What is the main difference between type IV hypersensitivity and the other three types of hypersensitivity?
Which T-cell subtype is involved in delayed-type hypersensitivities (DTH)?
Which T-cell subtype is involved in delayed-type hypersensitivities (DTH)?
What is the sensitization step in delayed-type hypersensitivities (DTH)?
What is the sensitization step in delayed-type hypersensitivities (DTH)?
What is the effector mechanism in delayed-type hypersensitivities (DTH)?
What is the effector mechanism in delayed-type hypersensitivities (DTH)?
What is an example of TH1-mediated hypersensitivity?
What is an example of TH1-mediated hypersensitivity?
What is the result of CD4 TH2-mediated reactions?
What is the result of CD4 TH2-mediated reactions?
What is the result of CD8 cytotoxic T lymphocyte (CTL)-mediated reactions?
What is the result of CD8 cytotoxic T lymphocyte (CTL)-mediated reactions?
What is the role of antigen presenting cells (APCs) in CD8 CTL-mediated reactions?
What is the role of antigen presenting cells (APCs) in CD8 CTL-mediated reactions?
What do activated CTLs target in CD8 CTL-mediated reactions?
What do activated CTLs target in CD8 CTL-mediated reactions?
What is the effector mechanism in CD8 CTL-mediated reactions?
What is the effector mechanism in CD8 CTL-mediated reactions?
What is the difference between CD4 TH1-mediated reactions and CD4 TH2-mediated reactions?
What is the difference between CD4 TH1-mediated reactions and CD4 TH2-mediated reactions?
What is the difference between CD8 CTL-mediated reactions and CD4 TH1-mediated reactions?
What is the difference between CD8 CTL-mediated reactions and CD4 TH1-mediated reactions?
What type of cells are involved in regulating Type IV hypersensitivities?
What type of cells are involved in regulating Type IV hypersensitivities?
How many subcategories can Type IV hypersensitivities be organized into?
How many subcategories can Type IV hypersensitivities be organized into?
Which T-cell subtype is responsible for much of the tissue damage in delayed-type hypersensitivities (DTH)?
Which T-cell subtype is responsible for much of the tissue damage in delayed-type hypersensitivities (DTH)?
What condition is caused by CD4 TH2-mediated reactions?
What condition is caused by CD4 TH2-mediated reactions?
What is the association between CD8 cytotoxic T lymphocyte (CTL)-mediated reactions and tissue transplant rejection?
What is the association between CD8 cytotoxic T lymphocyte (CTL)-mediated reactions and tissue transplant rejection?
What causes Hypersensitivity pneumonitis (HP)?
What causes Hypersensitivity pneumonitis (HP)?
What types of hypersensitivities are associated with pathology in Hypersensitivity pneumonitis (HP)?
What types of hypersensitivities are associated with pathology in Hypersensitivity pneumonitis (HP)?
What diagnostic tests are required to diagnose Type I hypersensitivities?
What diagnostic tests are required to diagnose Type I hypersensitivities?
What test can be performed to identify the antigens responsible for a type I reaction allergy?
What test can be performed to identify the antigens responsible for a type I reaction allergy?
Why can Type III hypersensitivities often be misdiagnosed?
Why can Type III hypersensitivities often be misdiagnosed?
What is the purpose of desensitization therapy?
What is the purpose of desensitization therapy?
How is emergency systemic anaphylaxis initially treated?
How is emergency systemic anaphylaxis initially treated?
What is the treatment for Type III hypersensitivities?
What is the treatment for Type III hypersensitivities?
Why can type III hypersensitivities often be misdiagnosed?
Why can type III hypersensitivities often be misdiagnosed?
What is the initial treatment for emergency systemic anaphylaxis?
What is the initial treatment for emergency systemic anaphylaxis?
What regulates type IV hypersensitivities?
What regulates type IV hypersensitivities?
What are CD8 cytotoxic T lymphocyte (CTL)-mediated reactions associated with?
What are CD8 cytotoxic T lymphocyte (CTL)-mediated reactions associated with?
What is the effector mechanism involved in CD4 TH1-mediated reactions?
What is the effector mechanism involved in CD4 TH1-mediated reactions?
What is the association between CD8 CTL-mediated reactions and tissue transplant rejection?
What is the association between CD8 CTL-mediated reactions and tissue transplant rejection?
What is the cause of Hypersensitivity pneumonitis (HP)?
What is the cause of Hypersensitivity pneumonitis (HP)?
What type of hypersensitivity can be due to both immune complexes and TH1 cells and macrophages?
What type of hypersensitivity can be due to both immune complexes and TH1 cells and macrophages?
Why can type III hypersensitivities often be misdiagnosed?
Why can type III hypersensitivities often be misdiagnosed?
What is desensitization therapy used for?
What is desensitization therapy used for?
What is the treatment for type III hypersensitivities?
What is the treatment for type III hypersensitivities?
Which type of hypersensitivity is regulated by T cells and involves the action of effector cells?
Which type of hypersensitivity is regulated by T cells and involves the action of effector cells?
What is the antigen presenting cell responsible for presenting antigens to T cells in delayed-type hypersensitivities?
What is the antigen presenting cell responsible for presenting antigens to T cells in delayed-type hypersensitivities?
What is the treatment for type III hypersensitivities?
What is the treatment for type III hypersensitivities?
What is the diagnostic test used to identify antigens responsible for a type I reaction allergy?
What is the diagnostic test used to identify antigens responsible for a type I reaction allergy?
What is the emergency treatment for systemic anaphylaxis?
What is the emergency treatment for systemic anaphylaxis?
What is the mechanism of CD8 CTL-mediated reactions?
What is the mechanism of CD8 CTL-mediated reactions?
What is the mechanism of type IV hypersensitivities?
What is the mechanism of type IV hypersensitivities?
What is the mechanism of CD4 TH2-mediated reactions?
What is the mechanism of CD4 TH2-mediated reactions?
What is the effector mechanism of CD4 TH1-mediated reactions in type IV hypersensitivities?
What is the effector mechanism of CD4 TH1-mediated reactions in type IV hypersensitivities?
What is the effector mechanism of CD4 TH2-mediated reactions in type IV hypersensitivities?
What is the effector mechanism of CD4 TH2-mediated reactions in type IV hypersensitivities?
Which of the following is NOT a cause of Hypersensitivity pneumonitis (HP)?
Which of the following is NOT a cause of Hypersensitivity pneumonitis (HP)?
What type of hypersensitivity is associated with tissue transplant rejection and contact dermatitis?
What type of hypersensitivity is associated with tissue transplant rejection and contact dermatitis?
What is the initial treatment for emergency systemic anaphylaxis?
What is the initial treatment for emergency systemic anaphylaxis?
What is the diagnostic test used to identify antigens responsible for a type I reaction allergy?
What is the diagnostic test used to identify antigens responsible for a type I reaction allergy?
What is the effector mechanism of type III hypersensitivities?
What is the effector mechanism of type III hypersensitivities?
What is the treatment for type III hypersensitivities?
What is the treatment for type III hypersensitivities?
What type of hypersensitivity requires several diagnostic tests in addition to a well-documented patient history for diagnosis?
What type of hypersensitivity requires several diagnostic tests in addition to a well-documented patient history for diagnosis?
What is the role of effector cells in type IV hypersensitivities?
What is the role of effector cells in type IV hypersensitivities?
What is the name of the diagnostic test used for type IV hypersensitivities?
What is the name of the diagnostic test used for type IV hypersensitivities?
What is the effector mechanism of CD8 CTL-mediated reactions in type IV hypersensitivities?
What is the effector mechanism of CD8 CTL-mediated reactions in type IV hypersensitivities?
What is hypersensitivity pneumonitis (HP)?
What is hypersensitivity pneumonitis (HP)?
What are the two types of hypersensitivities that can cause pathology associated with HP?
What are the two types of hypersensitivities that can cause pathology associated with HP?
How is a type I hypersensitivity diagnosed?
How is a type I hypersensitivity diagnosed?
What is desensitization therapy?
What is desensitization therapy?
What is the initial treatment for emergency systemic anaphylaxis?
What is the initial treatment for emergency systemic anaphylaxis?
What are CD4 TH1-mediated reactions responsible for?
What are CD4 TH1-mediated reactions responsible for?
What are CD4 TH2-mediated reactions associated with?
What are CD4 TH2-mediated reactions associated with?
What are CD8 cytotoxic T lymphocyte (CTL)-mediated reactions associated with?
What are CD8 cytotoxic T lymphocyte (CTL)-mediated reactions associated with?
What is Type IV hypersensitivity regulated by?
What is Type IV hypersensitivity regulated by?
What are the three subcategories of Type IV hypersensitivities based on?
What are the three subcategories of Type IV hypersensitivities based on?
What is the treatment for Type III hypersensitivities?
What is the treatment for Type III hypersensitivities?
Why can Type III hypersensitivities often be misdiagnosed?
Why can Type III hypersensitivities often be misdiagnosed?
Which type of hypersensitivity is associated with chronic asthma and allergic rhinitis?
Which type of hypersensitivity is associated with chronic asthma and allergic rhinitis?
What is the pathology associated with Hypersensitivity pneumonitis (HP)?
What is the pathology associated with Hypersensitivity pneumonitis (HP)?
What is the treatment for type III hypersensitivities?
What is the treatment for type III hypersensitivities?
What is the initial treatment for emergency systemic anaphylaxis?
What is the initial treatment for emergency systemic anaphylaxis?
What is the diagnostic test used to identify the antigens responsible for a type I reaction allergy?
What is the diagnostic test used to identify the antigens responsible for a type I reaction allergy?
Which subcategories can type IV hypersensitivities be organized into?
Which subcategories can type IV hypersensitivities be organized into?
What is the role of CD8 cytotoxic T lymphocytes in tissue transplant rejection?
What is the role of CD8 cytotoxic T lymphocytes in tissue transplant rejection?
What is the cause of Hypersensitivity pneumonitis (HP)?
What is the cause of Hypersensitivity pneumonitis (HP)?
What is the mechanism of type IV hypersensitivities?
What is the mechanism of type IV hypersensitivities?
What is desensitization therapy used for?
What is desensitization therapy used for?
What is the mechanism of CD4 TH1-mediated reactions?
What is the mechanism of CD4 TH1-mediated reactions?
What is the diagnostic requirement for type I hypersensitivities?
What is the diagnostic requirement for type I hypersensitivities?
What is the mechanism of Type IV hypersensitivities?
What is the mechanism of Type IV hypersensitivities?
What are the three subcategories of Type IV hypersensitivities based on?
What are the three subcategories of Type IV hypersensitivities based on?
What are CD4 TH1-mediated reactions responsible for?
What are CD4 TH1-mediated reactions responsible for?
What do CD4 TH2-mediated reactions result in?
What do CD4 TH2-mediated reactions result in?
What are CD8 cytotoxic T lymphocyte (CTL)-mediated reactions associated with?
What are CD8 cytotoxic T lymphocyte (CTL)-mediated reactions associated with?
What causes Hypersensitivity pneumonitis (HP)?
What causes Hypersensitivity pneumonitis (HP)?
What are the two types of hypersensitivities associated with Hypersensitivity pneumonitis (HP)?
What are the two types of hypersensitivities associated with Hypersensitivity pneumonitis (HP)?
What diagnostic tests are required for the diagnosis of Type I hypersensitivities?
What diagnostic tests are required for the diagnosis of Type I hypersensitivities?
What test can be performed to identify the antigens responsible for a Type I reaction allergy?
What test can be performed to identify the antigens responsible for a Type I reaction allergy?
Why are Type III hypersensitivities often misdiagnosed?
Why are Type III hypersensitivities often misdiagnosed?
What is desensitization therapy used for?
What is desensitization therapy used for?
How is emergency systemic anaphylaxis initially treated?
How is emergency systemic anaphylaxis initially treated?
What is the treatment for Type III hypersensitivities?
What is the treatment for Type III hypersensitivities?
What is the mechanism of Type IV hypersensitivities?
What is the mechanism of Type IV hypersensitivities?
Which subcategories can Type IV hypersensitivities be organized into?
Which subcategories can Type IV hypersensitivities be organized into?
What are CD4 TH1-mediated reactions responsible for?
What are CD4 TH1-mediated reactions responsible for?
What is the result of CD4 TH2-mediated reactions?
What is the result of CD4 TH2-mediated reactions?
What are CD8 cytotoxic T lymphocyte (CTL)-mediated reactions associated with?
What are CD8 cytotoxic T lymphocyte (CTL)-mediated reactions associated with?
What causes Hypersensitivity pneumonitis (HP)?
What causes Hypersensitivity pneumonitis (HP)?
What types of hypersensitivities can cause pathology associated with HP?
What types of hypersensitivities can cause pathology associated with HP?
What diagnostic tests are required for the diagnosis of type I hypersensitivities?
What diagnostic tests are required for the diagnosis of type I hypersensitivities?
What tests can be performed to identify the antigens responsible for a type I reaction allergy?
What tests can be performed to identify the antigens responsible for a type I reaction allergy?
Why are type III hypersensitivities often misdiagnosed?
Why are type III hypersensitivities often misdiagnosed?
What is the purpose of desensitization therapy?
What is the purpose of desensitization therapy?
What is the initial treatment for emergency systemic anaphylaxis?
What is the initial treatment for emergency systemic anaphylaxis?
Study Notes
Understanding Hypersensitivities: Types, Diagnosis, and Treatment
- Type IV hypersensitivities are regulated by T cells and involve the action of effector cells.
- Type IV hypersensitivities can be organized into three subcategories based on T-cell subtype, type of antigen, and the resulting effector mechanism.
- CD4 TH1-mediated reactions are described as delayed-type hypersensitivities (DTH) and are responsible for much of the tissue damage.
- CD4 TH2-mediated reactions result in chronic asthma or chronic allergic rhinitis.
- CD8 cytotoxic T lymphocyte (CTL)-mediated reactions are associated with tissue transplant rejection and contact dermatitis.
- Hypersensitivity pneumonitis (HP) occurs when the lungs become inflamed due to an allergic reaction to inhaled dust, endospores, bird feathers, bird droppings, molds, or chemicals.
- Pathology associated with HP can be due to both type III (mediated by immune complexes) and type IV (mediated by TH1 cells and macrophages) hypersensitivities.
- Diagnosis of type I hypersensitivities requires several diagnostic tests in addition to a well-documented patient history.
- Prick puncture skin test (PPST) or an intradermal test can be performed to identify the antigens responsible for a type I reaction allergy.
- Type III hypersensitivities can often be misdiagnosed because of their nonspecific inflammatory nature.
- Desensitization therapy can be used to reduce the hypersensitivity reaction through repeated injections of allergens.
- Emergency systemic anaphylaxis is treated initially with an epinephrine injection, which can counteract the drop in blood pressure.
- Treatment of type III hypersensitivities includes preventing further exposure to the antigen and the use of anti-inflammatory drugs.
Understanding Hypersensitivities: Types, Diagnosis, and Treatment
- Type IV hypersensitivities are regulated by T cells and involve the action of effector cells.
- Type IV hypersensitivities can be organized into three subcategories based on T-cell subtype, type of antigen, and the resulting effector mechanism.
- CD4 TH1-mediated reactions are described as delayed-type hypersensitivities (DTH) and are responsible for much of the tissue damage.
- CD4 TH2-mediated reactions result in chronic asthma or chronic allergic rhinitis.
- CD8 cytotoxic T lymphocyte (CTL)-mediated reactions are associated with tissue transplant rejection and contact dermatitis.
- Hypersensitivity pneumonitis (HP) occurs when the lungs become inflamed due to an allergic reaction to inhaled dust, endospores, bird feathers, bird droppings, molds, or chemicals.
- Pathology associated with HP can be due to both type III (mediated by immune complexes) and type IV (mediated by TH1 cells and macrophages) hypersensitivities.
- Diagnosis of type I hypersensitivities requires several diagnostic tests in addition to a well-documented patient history.
- Prick puncture skin test (PPST) or an intradermal test can be performed to identify the antigens responsible for a type I reaction allergy.
- Type III hypersensitivities can often be misdiagnosed because of their nonspecific inflammatory nature.
- Desensitization therapy can be used to reduce the hypersensitivity reaction through repeated injections of allergens.
- Emergency systemic anaphylaxis is treated initially with an epinephrine injection, which can counteract the drop in blood pressure.
- Treatment of type III hypersensitivities includes preventing further exposure to the antigen and the use of anti-inflammatory drugs.
Understanding Hypersensitivities: Types, Diagnosis, and Treatment
- Type IV hypersensitivities are regulated by T cells and involve the action of effector cells.
- Type IV hypersensitivities can be organized into three subcategories based on T-cell subtype, type of antigen, and the resulting effector mechanism.
- CD4 TH1-mediated reactions are described as delayed-type hypersensitivities (DTH) and are responsible for much of the tissue damage.
- CD4 TH2-mediated reactions result in chronic asthma or chronic allergic rhinitis.
- CD8 cytotoxic T lymphocyte (CTL)-mediated reactions are associated with tissue transplant rejection and contact dermatitis.
- Hypersensitivity pneumonitis (HP) occurs when the lungs become inflamed due to an allergic reaction to inhaled dust, endospores, bird feathers, bird droppings, molds, or chemicals.
- Pathology associated with HP can be due to both type III (mediated by immune complexes) and type IV (mediated by TH1 cells and macrophages) hypersensitivities.
- Diagnosis of type I hypersensitivities requires several diagnostic tests in addition to a well-documented patient history.
- Prick puncture skin test (PPST) or an intradermal test can be performed to identify the antigens responsible for a type I reaction allergy.
- Type III hypersensitivities can often be misdiagnosed because of their nonspecific inflammatory nature.
- Desensitization therapy can be used to reduce the hypersensitivity reaction through repeated injections of allergens.
- Emergency systemic anaphylaxis is treated initially with an epinephrine injection, which can counteract the drop in blood pressure.
- Treatment of type III hypersensitivities includes preventing further exposure to the antigen and the use of anti-inflammatory drugs.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge of Type IV Hypersensitivities with this quiz! Learn about the different subcategories of Type IV hypersensitivities and the mechanisms behind them. Challenge yourself with questions on T-cell subtypes, antigen types, and effector mechanisms. Perfect for medical and immunology students or anyone interested in understanding this complex immune response.
