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Questions and Answers
Which of the following is NOT a function of Rb, p16, or p53 in the regulation of the cell cycle?
Which of the following is NOT a function of Rb, p16, or p53 in the regulation of the cell cycle?
- Maintenance of genomic stability
- Inhibition of cell cycle progression
- Promotion of cell cycle progression (correct)
- Induction of cell cycle arrest
Which of the following is a key event that occurs during anaphase?
Which of the following is a key event that occurs during anaphase?
- Chromatin condensation
- Formation of the mitotic spindle
- Sister chromatids move to opposite poles (correct)
- Breakdown of the nuclear envelope
What is the role of Cyclin B/CDK1 in mitosis?
What is the role of Cyclin B/CDK1 in mitosis?
- Regulating the transition from metaphase to anaphase (correct)
- Promoting DNA replication
- Inducing cell cycle arrest
- Initiating chromatin condensation
What is the role of cohesins in mitosis?
What is the role of cohesins in mitosis?
Which of the following cellular components contributes to the formation of the mitotic spindle?
Which of the following cellular components contributes to the formation of the mitotic spindle?
What is a metaphase spread?
What is a metaphase spread?
Which family of CKIs specifically inhibits CDK4 and CDK6/Cyclin D, blocking the G1 phase?
Which family of CKIs specifically inhibits CDK4 and CDK6/Cyclin D, blocking the G1 phase?
Which family of CKIs has a broader range of inhibition, inhibiting CDK2/Cyclin E, CDK2/Cyclin A, CDK1/Cyclin A, and CDK1/Cyclin B?
Which family of CKIs has a broader range of inhibition, inhibiting CDK2/Cyclin E, CDK2/Cyclin A, CDK1/Cyclin A, and CDK1/Cyclin B?
What is the function of the E2F transcription factors?
What is the function of the E2F transcription factors?
Which protein product of oncogenes often results in loss of cell cycle control?
Which protein product of oncogenes often results in loss of cell cycle control?
Which protein kinases are activated in response to DNA damage or unreplicated DNA?
Which protein kinases are activated in response to DNA damage or unreplicated DNA?
What is the consequence of mutations in the ATM gene?
What is the consequence of mutations in the ATM gene?
Which of the following best describes the phases of the cell cycle?
Which of the following best describes the phases of the cell cycle?
What is the role of cyclins and cyclin-dependent kinases (CDK) in regulating the cell cycle?
What is the role of cyclins and cyclin-dependent kinases (CDK) in regulating the cell cycle?
Which of the following describes the restriction point in the cell cycle?
Which of the following describes the restriction point in the cell cycle?
How does a growth factor promote cell cycle progression through the restriction point?
How does a growth factor promote cell cycle progression through the restriction point?
What are the cell cycle checkpoints for damage control?
What are the cell cycle checkpoints for damage control?
What are the stages of mitosis?
What are the stages of mitosis?
Which protein binds to E2F transcription factors to inhibit transcriptional activation of target genes required for the G1 to S transition?
Which protein binds to E2F transcription factors to inhibit transcriptional activation of target genes required for the G1 to S transition?
Which protein inhibits Cyclin D/CDK4 and Cyclin D/CDK6 complexes, blocking the G1 phase of the cell cycle?
Which protein inhibits Cyclin D/CDK4 and Cyclin D/CDK6 complexes, blocking the G1 phase of the cell cycle?
Which protein, induced by DNA damage, activates transcription of p21 and other genes involved in G1 to S arrest?
Which protein, induced by DNA damage, activates transcription of p21 and other genes involved in G1 to S arrest?
What happens when Cyclin D levels increase in the cell?
What happens when Cyclin D levels increase in the cell?
What is the role of p21 in the cell cycle?
What is the role of p21 in the cell cycle?
What is the function of p53 in the cell cycle?
What is the function of p53 in the cell cycle?
Which enzyme is responsible for phosphorylating multiple target proteins required for condensation of chromosomes, breakdown of the nuclear envelope, and formation of the mitotic spindle?
Which enzyme is responsible for phosphorylating multiple target proteins required for condensation of chromosomes, breakdown of the nuclear envelope, and formation of the mitotic spindle?
Which proteins are responsible for creating interstrand crosslinkages and holding replicated chromosomes (sister chromatids) together during prophase?
Which proteins are responsible for creating interstrand crosslinkages and holding replicated chromosomes (sister chromatids) together during prophase?
What causes the breakdown of the nuclear envelope during prophase?
What causes the breakdown of the nuclear envelope during prophase?
What triggers the migration of centrosomes to opposite poles and the formation of the mitotic spindle during prophase?
What triggers the migration of centrosomes to opposite poles and the formation of the mitotic spindle during prophase?
What serves as the attachment site for microtubules of the mitotic spindle during mitosis?
What serves as the attachment site for microtubules of the mitotic spindle during mitosis?
What triggers the degradation of cohesins and cyclin B, leading to the separation of sister chromatids and progression to anaphase?
What triggers the degradation of cohesins and cyclin B, leading to the separation of sister chromatids and progression to anaphase?
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