30 Questions
Which of the following is NOT a function of Rb, p16, or p53 in the regulation of the cell cycle?
Promotion of cell cycle progression
Which of the following is a key event that occurs during anaphase?
Sister chromatids move to opposite poles
What is the role of Cyclin B/CDK1 in mitosis?
Regulating the transition from metaphase to anaphase
What is the role of cohesins in mitosis?
Maintaining sister chromatid cohesion
Which of the following cellular components contributes to the formation of the mitotic spindle?
Centrosomes
What is a metaphase spread?
A technique used to visualize chromosomes
Which family of CKIs specifically inhibits CDK4 and CDK6/Cyclin D, blocking the G1 phase?
INK4 Family of CKIs
Which family of CKIs has a broader range of inhibition, inhibiting CDK2/Cyclin E, CDK2/Cyclin A, CDK1/Cyclin A, and CDK1/Cyclin B?
Cip/Kip Family of CKIs
What is the function of the E2F transcription factors?
Activate transcription of target genes
Which protein product of oncogenes often results in loss of cell cycle control?
Cyclin D
Which protein kinases are activated in response to DNA damage or unreplicated DNA?
ATR and ATM
What is the consequence of mutations in the ATM gene?
Inability to detect double-strand breaks in DNA
Which of the following best describes the phases of the cell cycle?
Mitosis and Interphase
What is the role of cyclins and cyclin-dependent kinases (CDK) in regulating the cell cycle?
Formation of CDK/Cyclin complexes
Which of the following describes the restriction point in the cell cycle?
A point where the cell decides to continue or exit the cell cycle
How does a growth factor promote cell cycle progression through the restriction point?
By regulating CDK activity
What are the cell cycle checkpoints for damage control?
DNA damage control and tumor suppressor genes
What are the stages of mitosis?
Prophase, metaphase, anaphase, telophase
Which protein binds to E2F transcription factors to inhibit transcriptional activation of target genes required for the G1 to S transition?
Rb
Which protein inhibits Cyclin D/CDK4 and Cyclin D/CDK6 complexes, blocking the G1 phase of the cell cycle?
p16
Which protein, induced by DNA damage, activates transcription of p21 and other genes involved in G1 to S arrest?
p53
What happens when Cyclin D levels increase in the cell?
Rb is phosphorylated
What is the role of p21 in the cell cycle?
Inhibits Cyclin E/CDK2
What is the function of p53 in the cell cycle?
Activates transcription of p21
Which enzyme is responsible for phosphorylating multiple target proteins required for condensation of chromosomes, breakdown of the nuclear envelope, and formation of the mitotic spindle?
Cyclin B/CDK1 complex
Which proteins are responsible for creating interstrand crosslinkages and holding replicated chromosomes (sister chromatids) together during prophase?
Cohesins
What causes the breakdown of the nuclear envelope during prophase?
Phosphorylation of lamins by Cyclin B/CDK1
What triggers the migration of centrosomes to opposite poles and the formation of the mitotic spindle during prophase?
Cyclin B/CDK1
What serves as the attachment site for microtubules of the mitotic spindle during mitosis?
Kinetochore
What triggers the degradation of cohesins and cyclin B, leading to the separation of sister chromatids and progression to anaphase?
Anaphase Promoting Complex (APC)
Quiz: Cell Cycle Regulation and CKIs in Wolof Tëst: Ngir jënd ak jëkkat jëndiñ, ak CKIs Jënd: Tëst ngir jënd ak jëkkat jëndiñ ak CKIs, ak jëndiñ INK4 (p15, p16, p18, p19) ñi ngiru CDK4, CDK6/Cyclin
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