Cell Cycle Regulation Quiz

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What inhibits anaphase if even a single kinetochore is unattached or lacks tension?

Activation of APC/CCdc20

Mps1 kinase phosphorylation of Knl1 (correct)

Dephosphorylation of Knl1 by Protein phosphatase 1

Silencing of the spindle position checkpoint pathway

Which complex is formed by Mad2, BubR1, Bub3, and Cdc20 in the spindle assembly checkpoint pathway?

Mitotic Checkpoint Complex (MCC) (correct)

KnL1 complex

Mad1-Mad2 complex

APC/CCdc20

Which protein dephosphorylates Knl1, eliminating checkpoint protein binding sites at kinetochores?

Mad2

Protein phosphatase 1 (correct)

BubR1

Cdc20

What is the role of active Mad2 in the spindle assembly checkpoint pathway?

Inhibiting APC/CCdc20 Signup and view all the answers

What is the function of p31comet in the spindle assembly checkpoint pathway?

Disassembling the Mitotic Checkpoint Complex (MCC) Signup and view all the answers

What triggers the activation of the Mad1-Mad2 complex in the spindle assembly checkpoint pathway?

Unattached kinetochores Signup and view all the answers

Which kinase phosphorylates Knl1 when kinetochores are unattached to microtubules?

Mps1 kinase Signup and view all the answers

Which proteins form the spindle position checkpoint pathway?

Not specified in the text Signup and view all the answers

What happens to APC/CCdc20 when Mad2 is active?

It is inhibited from ubiquitinylating substrates Signup and view all the answers

What is the consequence of Knl1 phosphorylation by the Mps1 kinase when kinetochores are not attached to microtubules?

Recruitment of checkpoint pathway components Signup and view all the answers

What role does the Mad1-Mad2 complex play in the spindle assembly checkpoint pathway?

Inhibiting anaphase initiation Signup and view all the answers

What is the function of the Mitotic Checkpoint Complex (MCC) in the spindle assembly checkpoint pathway?

Forming a complex that blocks CDC20 activity Signup and view all the answers

Which protein is responsible for dephosphorylating Knl1 to eliminate checkpoint protein binding sites at kinetochores?

Protein phosphatase 1 Signup and view all the answers

What triggers the activation of APC/CCdc20 in the spindle assembly checkpoint pathway?

Correct attachment of all chromosomes to the mitotic spindle Signup and view all the answers

Which kinase is involved in phosphorylating Knl1 when kinetochores are not attached to microtubules?

Mps1 Signup and view all the answers

In the spindle assembly checkpoint pathway, what is the role of p31comet?

Disassembling the MCC Signup and view all the answers

Cell Cycle Regulation Quiz

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Questions and Answers

What inhibits anaphase if even a single kinetochore is unattached or lacks tension?

Which complex is formed by Mad2, BubR1, Bub3, and Cdc20 in the spindle assembly checkpoint pathway?

Which protein dephosphorylates Knl1, eliminating checkpoint protein binding sites at kinetochores?

What is the role of active Mad2 in the spindle assembly checkpoint pathway?

What is the function of p31comet in the spindle assembly checkpoint pathway?

What triggers the activation of the Mad1-Mad2 complex in the spindle assembly checkpoint pathway?

Which kinase phosphorylates Knl1 when kinetochores are unattached to microtubules?

Which proteins form the spindle position checkpoint pathway?

What happens to APC/CCdc20 when Mad2 is active?

What is the consequence of Knl1 phosphorylation by the Mps1 kinase when kinetochores are not attached to microtubules?

What role does the Mad1-Mad2 complex play in the spindle assembly checkpoint pathway?

What is the function of the Mitotic Checkpoint Complex (MCC) in the spindle assembly checkpoint pathway?

Which protein is responsible for dephosphorylating Knl1 to eliminate checkpoint protein binding sites at kinetochores?

What triggers the activation of APC/CCdc20 in the spindle assembly checkpoint pathway?

Which kinase is involved in phosphorylating Knl1 when kinetochores are not attached to microtubules?

In the spindle assembly checkpoint pathway, what is the role of p31comet?

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