16 Questions
What inhibits anaphase if even a single kinetochore is unattached or lacks tension?
Mps1 kinase phosphorylation of Knl1
Which complex is formed by Mad2, BubR1, Bub3, and Cdc20 in the spindle assembly checkpoint pathway?
Mitotic Checkpoint Complex (MCC)
Which protein dephosphorylates Knl1, eliminating checkpoint protein binding sites at kinetochores?
Protein phosphatase 1
What is the role of active Mad2 in the spindle assembly checkpoint pathway?
Inhibiting APC/CCdc20
What is the function of p31comet in the spindle assembly checkpoint pathway?
Disassembling the Mitotic Checkpoint Complex (MCC)
What triggers the activation of the Mad1-Mad2 complex in the spindle assembly checkpoint pathway?
Unattached kinetochores
Which kinase phosphorylates Knl1 when kinetochores are unattached to microtubules?
Mps1 kinase
Which proteins form the spindle position checkpoint pathway?
Not specified in the text
What happens to APC/CCdc20 when Mad2 is active?
It is inhibited from ubiquitinylating substrates
What is the consequence of Knl1 phosphorylation by the Mps1 kinase when kinetochores are not attached to microtubules?
Recruitment of checkpoint pathway components
What role does the Mad1-Mad2 complex play in the spindle assembly checkpoint pathway?
Inhibiting anaphase initiation
What is the function of the Mitotic Checkpoint Complex (MCC) in the spindle assembly checkpoint pathway?
Forming a complex that blocks CDC20 activity
Which protein is responsible for dephosphorylating Knl1 to eliminate checkpoint protein binding sites at kinetochores?
Protein phosphatase 1
What triggers the activation of APC/CCdc20 in the spindle assembly checkpoint pathway?
Correct attachment of all chromosomes to the mitotic spindle
Which kinase is involved in phosphorylating Knl1 when kinetochores are not attached to microtubules?
Mps1
In the spindle assembly checkpoint pathway, what is the role of p31comet?
Disassembling the MCC
Test your knowledge on the regulation of the cell cycle from metaphase to anaphase transition, including the roles of separase, Scc1, Cdc14, Cdh1, APC/C, Cyclin B, Cyclin A, CDK1, Golgi fragmentation, and more.
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