Cell Cycle Regulation Quiz
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Questions and Answers

What inhibits anaphase if even a single kinetochore is unattached or lacks tension?

  • Activation of APC/CCdc20
  • Mps1 kinase phosphorylation of Knl1 (correct)
  • Dephosphorylation of Knl1 by Protein phosphatase 1
  • Silencing of the spindle position checkpoint pathway
  • Which complex is formed by Mad2, BubR1, Bub3, and Cdc20 in the spindle assembly checkpoint pathway?

  • Mitotic Checkpoint Complex (MCC) (correct)
  • KnL1 complex
  • Mad1-Mad2 complex
  • APC/CCdc20
  • Which protein dephosphorylates Knl1, eliminating checkpoint protein binding sites at kinetochores?

  • Mad2
  • Protein phosphatase 1 (correct)
  • BubR1
  • Cdc20
  • What is the role of active Mad2 in the spindle assembly checkpoint pathway?

    <p>Inhibiting APC/CCdc20</p> Signup and view all the answers

    What is the function of p31comet in the spindle assembly checkpoint pathway?

    <p>Disassembling the Mitotic Checkpoint Complex (MCC)</p> Signup and view all the answers

    What triggers the activation of the Mad1-Mad2 complex in the spindle assembly checkpoint pathway?

    <p>Unattached kinetochores</p> Signup and view all the answers

    Which kinase phosphorylates Knl1 when kinetochores are unattached to microtubules?

    <p>Mps1 kinase</p> Signup and view all the answers

    Which proteins form the spindle position checkpoint pathway?

    <p>Not specified in the text</p> Signup and view all the answers

    What happens to APC/CCdc20 when Mad2 is active?

    <p>It is inhibited from ubiquitinylating substrates</p> Signup and view all the answers

    What is the consequence of Knl1 phosphorylation by the Mps1 kinase when kinetochores are not attached to microtubules?

    <p>Recruitment of checkpoint pathway components</p> Signup and view all the answers

    What role does the Mad1-Mad2 complex play in the spindle assembly checkpoint pathway?

    <p>Inhibiting anaphase initiation</p> Signup and view all the answers

    What is the function of the Mitotic Checkpoint Complex (MCC) in the spindle assembly checkpoint pathway?

    <p>Forming a complex that blocks CDC20 activity</p> Signup and view all the answers

    Which protein is responsible for dephosphorylating Knl1 to eliminate checkpoint protein binding sites at kinetochores?

    <p>Protein phosphatase 1</p> Signup and view all the answers

    What triggers the activation of APC/CCdc20 in the spindle assembly checkpoint pathway?

    <p>Correct attachment of all chromosomes to the mitotic spindle</p> Signup and view all the answers

    Which kinase is involved in phosphorylating Knl1 when kinetochores are not attached to microtubules?

    <p>Mps1</p> Signup and view all the answers

    In the spindle assembly checkpoint pathway, what is the role of p31comet?

    <p>Disassembling the MCC</p> Signup and view all the answers

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