Podcast
Questions and Answers
What is the function of dendritic cells (DCs) in the immune system?
What is the function of dendritic cells (DCs) in the immune system?
- Activating cytotoxic T cells
- Capturing and presenting antigens (correct)
- Producing antibodies
- Enhancing natural killer cell activity
Which cells are considered antigen-presenting cells (APCs)?
Which cells are considered antigen-presenting cells (APCs)?
- Macrophages, dendritic cells, and B cells (correct)
- Natural killer cells
- Red blood cells
- Cytotoxic T cells
Why are antigen-presenting cells (APCs) particularly efficient in antigen presentation?
Why are antigen-presenting cells (APCs) particularly efficient in antigen presentation?
- Because they produce antibodies
- By directly activating cytotoxic T cells
- Due to their low expression of MHC molecules
- Their high expression of MHC molecules and co-stimulatory molecules (correct)
Where do dendritic cells (DCs) migrate to after capturing antigens?
Where do dendritic cells (DCs) migrate to after capturing antigens?
What is the main function of CD4+ helper T cells upon activation by APCs?
What is the main function of CD4+ helper T cells upon activation by APCs?
What is the purpose of antigen receptor gene rearrangement in T cells?
What is the purpose of antigen receptor gene rearrangement in T cells?
Which gene segments are involved in the recombination process to generate diversity in TCR Alpha chains?
Which gene segments are involved in the recombination process to generate diversity in TCR Alpha chains?
What is the primary function of the RAG complex during gene rearrangement in B and T cell development?
What is the primary function of the RAG complex during gene rearrangement in B and T cell development?
At which lymphocyte maturation checkpoint does positive selection for MHC recognition occur?
At which lymphocyte maturation checkpoint does positive selection for MHC recognition occur?
What is the main outcome of the gene rearrangement process in B and T cells?
What is the main outcome of the gene rearrangement process in B and T cells?
During gene rearrangement in the TCR Beta Chain Locus, what is the role of combinatorial diversity?
During gene rearrangement in the TCR Beta Chain Locus, what is the role of combinatorial diversity?
Which process introduces additional diversity through the imprecise joining of gene segments within the TCR Beta Chain Locus?
Which process introduces additional diversity through the imprecise joining of gene segments within the TCR Beta Chain Locus?
What is the main function of central tolerance during lymphocyte maturation?
What is the main function of central tolerance during lymphocyte maturation?
Which scenario would cause a lymphocyte to fail the peripheral tolerance checkpoint?
Which scenario would cause a lymphocyte to fail the peripheral tolerance checkpoint?
What is the term used to describe the event where lymphocytes respond to self-antigens, leading to autoimmune reactions?
What is the term used to describe the event where lymphocytes respond to self-antigens, leading to autoimmune reactions?
What is the role of anchor amino acids within a peptide sequence in peptide binding to MHC molecules?
What is the role of anchor amino acids within a peptide sequence in peptide binding to MHC molecules?
Why do different individuals express unique combinations of MHC alleles?
Why do different individuals express unique combinations of MHC alleles?
Which pathway describes antigen processing for display by class II MHC molecules?
Which pathway describes antigen processing for display by class II MHC molecules?
How are peptide fragments generated from endogenous proteins transported into the endoplasmic reticulum for class I MHC molecule binding?
How are peptide fragments generated from endogenous proteins transported into the endoplasmic reticulum for class I MHC molecule binding?
What contributes to individual differences in peptide presentation and immune responses?
What contributes to individual differences in peptide presentation and immune responses?
What is the primary mode of interaction between the TCR and MHC-peptide complex?
What is the primary mode of interaction between the TCR and MHC-peptide complex?
What role do ITAMs play in T cell activation?
What role do ITAMs play in T cell activation?
Which co-receptor enhances the binding of the TCR to the peptide-MHC complex?
Which co-receptor enhances the binding of the TCR to the peptide-MHC complex?
What is the role of Lck in a T cell upon TCR engagement?
What is the role of Lck in a T cell upon TCR engagement?
Which component of the TCR complex recognizes MHC class I molecules?
Which component of the TCR complex recognizes MHC class I molecules?
What determines the immunodominance of an epitope?
What determines the immunodominance of an epitope?
What is the main function of a T cell receptor (TCR)?
What is the main function of a T cell receptor (TCR)?
What is the role of co-receptors CD4 and CD8 on T cells?
What is the role of co-receptors CD4 and CD8 on T cells?
What ensures specificity in antigen recognition by T cells?
What ensures specificity in antigen recognition by T cells?
Which of the following factors does NOT influence the immunodominance of an epitope?
Which of the following factors does NOT influence the immunodominance of an epitope?
What is the role of the pre-T cell receptor during T cell development?
What is the role of the pre-T cell receptor during T cell development?
Which stage of T cell development is characterized by the expression of both CD4 and CD8 co-receptors?
Which stage of T cell development is characterized by the expression of both CD4 and CD8 co-receptors?
At which lymphocyte maturation checkpoint does negative selection for self-reactivity occur?
At which lymphocyte maturation checkpoint does negative selection for self-reactivity occur?
In response to signaling from the pre-T cell receptor, what happens to T cells?
In response to signaling from the pre-T cell receptor, what happens to T cells?
What is required for the activation and signaling of the pre-T cell receptor?
What is required for the activation and signaling of the pre-T cell receptor?
Which type of T cells express the CD4 co-receptor?
Which type of T cells express the CD4 co-receptor?
What is the main function of the Double-Negative (DN) Stage in T cell development?
What is the main function of the Double-Negative (DN) Stage in T cell development?
'Single-Positive (SP)' stage refers to the expression of which co-receptor by a T cell?
'Single-Positive (SP)' stage refers to the expression of which co-receptor by a T cell?
'Mature T Cell Stage' involves the exit from thymus to which type of organs?
'Mature T Cell Stage' involves the exit from thymus to which type of organs?
'Combinatorial diversity' in T cell receptors arises due to variations in which chains?
'Combinatorial diversity' in T cell receptors arises due to variations in which chains?
