10 Questions
What are the learning outcomes of this lesson?
Understand the principles of signal transduction in relation to normal cell growth and how this can be altered due to mutation in cancer. Using EGFR as an exemplar, understand how targeting GFRs and signalling pathways can have a therapeutic role in cancer. Know exemplars of drugs which target EGFR externally and internally at the TK domain. Understand mechanism of action of drugs. Understand how personalised medicine has a role in drug targeting of EGFR and MAPK. Understand when and why these drugs don’t work- MORE IN WORKSHOPS.
How does a normal cell divide?
A normal cell divides when it receives a signal from the body, usually in the form of a growth factor. This signal turns on growth transiently, and the cell divides. If another growth factor binds, the cell divides again.
What do many mutational events involved in cancer affect?
Many mutational events involved in cancer affect pathways occurring in cells which control the normal growth, survival, division, and death of the cell.
What is the role of personalized medicine in drug targeting of EGFR and MAPK?
Personalized medicine plays a role in drug targeting of EGFR and MAPK by tailoring treatment based on an individual's specific genetic makeup and cancer characteristics.
When and why may drugs targeting EGFR and MAPK not work?
Drugs targeting EGFR and MAPK may not work in certain cases, such as when there are mutations that render the targeted pathway ineffective or when the cancer develops resistance to the drugs.
Which of the following is a key principle of signal transduction in relation to normal cell growth?
Growth factors transiently turn on cell growth
What is the role of EGFR in targeted therapy?
EGFR can be targeted by drugs
Which of the following exemplifies drugs that target EGFR externally and internally at the TK domain?
Kinase inhibitors
What is the mechanism of action of drugs used in targeted therapy?
They target specific molecules involved in cancer
When and why may drugs targeting EGFR and MAPK not work?
They may not work if there are no mutations in EGFR and MAPK
Test your knowledge of targeted therapy in cancer treatment with this quiz! Learn about the principles of signal transduction and how it can be altered in cancer. Explore the therapeutic role of targeting EGFRs and signaling pathways. Discover examples of drugs that target EGFR externally.
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