Targeted Therapy in Cancer

Understand the principles of signal transduction in relation to normal cell growth and how this can be altered due to mutation in cancer. Using EGFR as an exemplar, understand how targeting GFRs and signalling pathways can have a therapeutic role in cancer. Know exemplars of drugs which target EGFR externally and internally at the TK domain. Understand mechanism of action of drugs. Understand how personalised medicine has a role in drug targeting of EGFR and MAPK. Understand when and why these drugs don’t work- MORE IN WORKSHOPS.

A normal cell divides when it receives a signal from the body, usually in the form of a growth factor. This signal turns on growth transiently, and the cell divides. If another growth factor binds, the cell divides again.

Many mutational events involved in cancer affect pathways occurring in cells which control the normal growth, survival, division, and death of the cell.

<p>Personalized medicine plays a role in drug targeting of EGFR and MAPK by tailoring treatment based on an individual's specific genetic makeup and cancer characteristics.</p> Signup and view all the answers

<p>Drugs targeting EGFR and MAPK may not work in certain cases, such as when there are mutations that render the targeted pathway ineffective or when the cancer develops resistance to the drugs.</p> Signup and view all the answers

<p>Growth factors transiently turn on cell growth</p> Signup and view all the answers

<p>EGFR can be targeted by drugs</p> Signup and view all the answers

<p>Kinase inhibitors</p> Signup and view all the answers

<p>They target specific molecules involved in cancer</p> Signup and view all the answers

<p>They may not work if there are no mutations in EGFR and MAPK</p> Signup and view all the answers