Podcast
Questions and Answers
Which neurotransmitter is synthesized from histidine?
Which neurotransmitter is synthesized from histidine?
- Epinephrine
- Histamine (correct)
- Norepinephrine
- Dopamine
Which type of receptors are D1 and D5 receptors?
Which type of receptors are D1 and D5 receptors?
- G-coupled
- Inhibitory
- Excitatory (correct)
- Autoreceptor
What is the main function of dopamine?
What is the main function of dopamine?
- Learning
- Reward (correct)
- Motor function
- Cognition
Which type of receptor triggers a second messenger system through G-proteins?
Which type of receptor triggers a second messenger system through G-proteins?
Which of the following is NOT a second messenger?
Which of the following is NOT a second messenger?
What is the net effect of EPSPs and IPSPs on the firing of a neuron?
What is the net effect of EPSPs and IPSPs on the firing of a neuron?
Which one of these is the correct function of glial cells in the brain?
Which one of these is the correct function of glial cells in the brain?
What is the role of ionotropic receptors in neuronal communication?
What is the role of ionotropic receptors in neuronal communication?
What is the difference between ionotropic and metabotropic receptors?
What is the difference between ionotropic and metabotropic receptors?
Which neurotransmitter is both ligand-gated and G-coupled?
Which neurotransmitter is both ligand-gated and G-coupled?
What is the main inhibitory neurotransmitter in the nervous system?
What is the main inhibitory neurotransmitter in the nervous system?
Which neurotransmitter has 5 receptor subtypes, some of which are excitatory and some inhibitory?
Which neurotransmitter has 5 receptor subtypes, some of which are excitatory and some inhibitory?
Which of the following families of voltage-dependent channels allow the flow of Ca2+ into the neuron and have a role in neurotransmitter release?
Which of the following families of voltage-dependent channels allow the flow of Ca2+ into the neuron and have a role in neurotransmitter release?
Which of the following ligand-gated channels is activated by ATP and allows the flow of Na+ and Ca2+ into the neuron?
Which of the following ligand-gated channels is activated by ATP and allows the flow of Na+ and Ca2+ into the neuron?
Which of the following ligand-gated channels is activated by serotonin and allows the flow of Na+ and Ca2+ into the neuron?
Which of the following ligand-gated channels is activated by serotonin and allows the flow of Na+ and Ca2+ into the neuron?
Which neurotransmitter is also a hormone secreted by adrenal glands?
Which neurotransmitter is also a hormone secreted by adrenal glands?
Which neurotransmitter has inhibitory effects on both postsynaptic neurons and autoreceptors?
Which neurotransmitter has inhibitory effects on both postsynaptic neurons and autoreceptors?
Which neurotransmitter is mainly produced by neurons in the tuberomammillary nucleus (TMN) in the posterior hypothalamus?
Which neurotransmitter is mainly produced by neurons in the tuberomammillary nucleus (TMN) in the posterior hypothalamus?
Which step in the drug development process involves screening compounds to identify the most promising hits?
Which step in the drug development process involves screening compounds to identify the most promising hits?
What is the purpose of the 'Hit to Lead' (HTL) stage in drug development?
What is the purpose of the 'Hit to Lead' (HTL) stage in drug development?
Which phase of clinical testing involves testing the compound in a relatively small number of patients with the disease of interest?
Which phase of clinical testing involves testing the compound in a relatively small number of patients with the disease of interest?
Which stage of drug development is known as the 'lead optimization' stage?
Which stage of drug development is known as the 'lead optimization' stage?
How many drugs out of 10 make it all the way through the clinic?
How many drugs out of 10 make it all the way through the clinic?
What is the estimated cost of drug development, depending on the disease and number of failures?
What is the estimated cost of drug development, depending on the disease and number of failures?
What are the key components involved in the development of new drugs?
What are the key components involved in the development of new drugs?
Which chapter(s) should be read for next week?
Which chapter(s) should be read for next week?
What is the title of the Journal Club paper by Pereira et al. that should be read?
What is the title of the Journal Club paper by Pereira et al. that should be read?
What is the title of the Journal Club paper by Bagher et al. that should be read?
What is the title of the Journal Club paper by Bagher et al. that should be read?
When is the seminar scheduled for?
When is the seminar scheduled for?
What is the purpose of the 'Final thoughts' section?
What is the purpose of the 'Final thoughts' section?
What are the two main types of receptors involved in neurotransmitter signaling?
What are the two main types of receptors involved in neurotransmitter signaling?
What are the two ways that neurotransmitter communication is stopped?
What are the two ways that neurotransmitter communication is stopped?
What are the two possible outcomes of ion flow through ion channels on post-synaptic neurons?
What are the two possible outcomes of ion flow through ion channels on post-synaptic neurons?
What are the two families of high/moderate voltage activated Cav channels?
What are the two families of high/moderate voltage activated Cav channels?
How many subtypes of human Kv channels are there?
How many subtypes of human Kv channels are there?
What is the role of ligand-gated P2X receptors?
What is the role of ligand-gated P2X receptors?
Which neurotransmitter degrades dopamine in both the postsynaptic neuron and astrocytes?
Which neurotransmitter degrades dopamine in both the postsynaptic neuron and astrocytes?
Which neurotransmitter is mainly produced by neurons in the tuberomammillary nucleus (TMN) in the posterior hypothalamus?
Which neurotransmitter is mainly produced by neurons in the tuberomammillary nucleus (TMN) in the posterior hypothalamus?
Which neurotransmitter has inhibitory effects on both postsynaptic neurons and autoreceptors?
Which neurotransmitter has inhibitory effects on both postsynaptic neurons and autoreceptors?
What is the function of glial cells in the brain?
What is the function of glial cells in the brain?
What are the two types of receptors that neurotransmitters can bind to?
What are the two types of receptors that neurotransmitters can bind to?
What is the difference between ionotropic and metabotropic receptors?
What is the difference between ionotropic and metabotropic receptors?
What are the three main pathways of dopamine?
What are the three main pathways of dopamine?
What are the main functions of dopamine?
What are the main functions of dopamine?
What are the five most prevalent neurotransmitters?
What are the five most prevalent neurotransmitters?
Which Drug Development Stage tries to improve on 'best compound' for a specific disease by trying to fix things like potency, selectivity, and pharmacokinetics?
Which Drug Development Stage tries to improve on 'best compound' for a specific disease by trying to fix things like potency, selectivity, and pharmacokinetics?
What is the purpose of the 'Hit to Lead' (HTL) stage in drug development?
What is the purpose of the 'Hit to Lead' (HTL) stage in drug development?
Which step in the drug development process involves screening compounds to identify the most promising hits?
Which step in the drug development process involves screening compounds to identify the most promising hits?
What are the major classes of neurotransmitters in the central nervous system?
What are the major classes of neurotransmitters in the central nervous system?
What is the role of peptides as neurotransmitters?
What is the role of peptides as neurotransmitters?
What are some examples of lipids released as neurotransmitters?
What are some examples of lipids released as neurotransmitters?
What are the key components involved in the development of new drugs?
What are the key components involved in the development of new drugs?
What is the estimated cost of drug development, depending on the disease and number of failures?
What is the estimated cost of drug development, depending on the disease and number of failures?
When is the seminar scheduled for?
When is the seminar scheduled for?
What is the purpose of the 'Hit to Lead' (HTL) stage in drug development?
What is the purpose of the 'Hit to Lead' (HTL) stage in drug development?
Which stage of drug development is known as the 'lead optimization' stage?
Which stage of drug development is known as the 'lead optimization' stage?
Which phase of clinical testing involves testing the compound in a relatively small number of patients with the disease of interest?
Which phase of clinical testing involves testing the compound in a relatively small number of patients with the disease of interest?
What is the purpose of the 'Final thoughts' section?
What is the purpose of the 'Final thoughts' section?
Which chapter(s) should be read for next week?
Which chapter(s) should be read for next week?
What is the title of the Journal Club paper by Pereira et al. that should be read?
What is the title of the Journal Club paper by Pereira et al. that should be read?
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