Exploring the Drug Discovery Process
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Questions and Answers

Which step of the drug discovery process involves identifying potential drug targets that play a pivotal role in disease?

  • Lead Candidate Selection
  • Target Validation
  • Candidate Identification
  • Target Identification (correct)

What is the goal of Drug Target Validation?

  • To select lead candidates
  • To screen large libraries of compounds
  • To evaluate the druggability of the drug target (correct)
  • To identify potential drug targets

What is druggability?

  • The process of lead candidate selection
  • The ability of a drug target to bind selectively and effectively by a drug (correct)
  • The process of identifying potential drug targets
  • The function of the drug target

What is the next step after Drug Target Validation?

<p>Candidate Identification (C)</p> Signup and view all the answers

What is the first step of small molecule drug development?

<p>Target Identification (B)</p> Signup and view all the answers

What is the purpose of lead candidate optimization?

<p>To improve the properties of the selected lead candidate (D)</p> Signup and view all the answers

Which method relies on computer-based modeling or simulation for drug target identification?

<p>In silico methods (D)</p> Signup and view all the answers

Which database provides information on over 11,000 already identified drugs and their corresponding targets?

<p>DrugBank (A)</p> Signup and view all the answers

What does the term 'in vitro' refer to?

<p>Methods done in cells (A)</p> Signup and view all the answers

What is the primary method for drug target identification that involves genetic evaluation?

<p>CRISPR (A)</p> Signup and view all the answers

What is the goal of lead candidate optimization?

<p>To improve the safety and efficacy profile of lead candidates (A)</p> Signup and view all the answers

What is a drug target?

<p>A molecule, protein, cell, or tissue targeted by a drug to produce a therapeutic effect (D)</p> Signup and view all the answers

Which of the following is a reason why some drug targets are considered undruggable?

<p>They are too ubiquitous (B)</p> Signup and view all the answers

What is the purpose of target validation in drug development?

<p>To demonstrate the therapeutic effect of modulating the drug target (B)</p> Signup and view all the answers

What does in silico validation involve in the drug discovery process?

<p>Computational modeling to simulate the behavior of the drug target (D)</p> Signup and view all the answers

What do in vitro and in vivo studies provide information on in drug development?

<p>The effects of biotherapeutic interventions (D)</p> Signup and view all the answers

What does RNA interference (RNAi) do in the drug discovery process?

<p>Blocks the messages of specific genes (C)</p> Signup and view all the answers

What is critical for the reliability of drug target identification and validation?

<p>Reproducibility of the results (D)</p> Signup and view all the answers

What is the purpose of drug target identification in the drug discovery process?

<p>To identify potential drug targets (D)</p> Signup and view all the answers

What is the goal of lead candidate optimization in the drug discovery process?

<p>To enhance the target and drug candidate (C)</p> Signup and view all the answers

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