Exploring the Drug Discovery Process

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Which step of the drug discovery process involves identifying potential drug targets that play a pivotal role in disease?

Lead Candidate Selection

Target Validation

Candidate Identification

Target Identification (correct)

What is the goal of Drug Target Validation?

To select lead candidates

To screen large libraries of compounds

To evaluate the druggability of the drug target (correct)

To identify potential drug targets

What is druggability?

The process of lead candidate selection

The ability of a drug target to bind selectively and effectively by a drug (correct)

The process of identifying potential drug targets

The function of the drug target

What is the next step after Drug Target Validation?

Candidate Identification Signup and view all the answers

What is the first step of small molecule drug development?

Target Identification Signup and view all the answers

What is the purpose of lead candidate optimization?

To improve the properties of the selected lead candidate Signup and view all the answers

Which method relies on computer-based modeling or simulation for drug target identification?

In silico methods Signup and view all the answers

Which database provides information on over 11,000 already identified drugs and their corresponding targets?

DrugBank Signup and view all the answers

What does the term 'in vitro' refer to?

Methods done in cells Signup and view all the answers

What is the primary method for drug target identification that involves genetic evaluation?

CRISPR Signup and view all the answers

What is the goal of lead candidate optimization?

To improve the safety and efficacy profile of lead candidates Signup and view all the answers

What is a drug target?

A molecule, protein, cell, or tissue targeted by a drug to produce a therapeutic effect Signup and view all the answers

Which of the following is a reason why some drug targets are considered undruggable?

They are too ubiquitous Signup and view all the answers

What is the purpose of target validation in drug development?

To demonstrate the therapeutic effect of modulating the drug target Signup and view all the answers

What does in silico validation involve in the drug discovery process?

Computational modeling to simulate the behavior of the drug target Signup and view all the answers

What do in vitro and in vivo studies provide information on in drug development?

The effects of biotherapeutic interventions Signup and view all the answers

What does RNA interference (RNAi) do in the drug discovery process?

Blocks the messages of specific genes Signup and view all the answers

What is critical for the reliability of drug target identification and validation?

Reproducibility of the results Signup and view all the answers

What is the purpose of drug target identification in the drug discovery process?

To identify potential drug targets Signup and view all the answers

What is the goal of lead candidate optimization in the drug discovery process?

To enhance the target and drug candidate Signup and view all the answers