17 Questions
Which type of T cells release IL-2, IL-4, and interferon-gamma?
Helper T cells (CD4)
What is the main function of IL-4 released by helper T cells?
Causes B-cell maturation into plasma cells
Which type of T cells recognize and attack non–self-antigens attached to MHC class I receptors?
Cytotoxic T cells (CD8)
Which cells are involved in delayed-type hypersensitivity and bring in inflammatory cells by chemokine secretion?
Helper T cells
What is the main effector cell in cell-mediated immunity?
Macrophages
What is the main infection associated with defects in cell-mediated immunity?
Viral infections
Which cytokine stimulates B cells to become plasma cells?
Interleukin-4 (IL-4)
Which immunoglobulin is secreted with reinfection?
IgG
What is the main function of suppressor T cells (CD8)?
To regulate CD4 and CD8 cells
What is the purpose of an intradermal skin test (e.g. TB skin test)?
To test for cell-mediated immunity
Which type of hypersensitivity reaction involves IgE receptors on mast cells and basophils?
Type I
What is the most abundant antibody in the body responsible for the secondary immune response?
IgG
Which antibody is found in secretions, in Peyer’s patches in the gut, and in breast milk?
IgA
Which antibody is responsible for initial antibody secretion after exposure to an antigen (primary immune response)?
IgM
Which cells recognize cells that lack self-MHC and are part of the body’s natural immunosurveillance for cancer?
Natural killer cells
In T-cell and B-cell activation, what provides the costimulatory signal required after alloantigen binds to antigen-specific receptors?
IL-1
Which type of infection leads to endocytosis of proteins, which get bound to class II MHC molecules and are recognized by CD4 helper T cells?
Bacterial infection
Test your knowledge about the role of helper T cells, suppressor T cells, and cytotoxic T cells in cell-mediated immunity, as well as their functions such as cytokine release and antigen recognition.
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