Lecture 13+14

Play an AI-generated podcast conversation about this lesson

What is the process that involves T cells migrating into the lymph node?

Diapedesis (correct)

Chemokine activation

Binding adhesion molecules

Antigen sampling

Which adhesion molecule is responsible for the weak attachment that leads to T cell rolling along the endothelial surface?

Chemokine

Integrin

Adhesion molecule

Selectin (correct)

What is the main function of fibroblastic reticular cells in the lymph nodes?

Secrete antibodies for antigen recognition

Secrete chemokines attracting T cells and DCs (correct)

Act as antigen-presenting cells to T cells

Destroy pathogens in the lymph nodes

Which molecule helps naïve T cells find their matches in the lymph nodes?

CCL21 Signup and view all the answers

What is the purpose of T cells scanning for antigens once they are in the lymph node?

To engage with dendritic cells Signup and view all the answers

How do naïve CD4+ T cells behave after engaging with the Antigen:MHC complex?

They arrest their movements and slow down Signup and view all the answers

What determines the kinetics of early encounters between T cells and dendritic cells in the lymph node?

Availability of antigens and activation state of a DC Signup and view all the answers

'Rolling -> Activation -> Arrest + Tight Binding -> Diapedesis -> Entering Lymph Node' represents which process in T cell migration?

'Migration cascade' Signup and view all the answers

'DCs can be surveyed by more than 5000 T cells per hour!' implies what about the interaction between dendritic cells and T cells?

'Scan and go' mechanism is involved Signup and view all the answers

Which segment types are needed to make a T cell receptor?

J, D, V Signup and view all the answers

What is the role of professional antigen-presenting cells?

Activate T cells through peptide presentation Signup and view all the answers

Which type of MHC molecules bind peptides of endogenous origin?

MHC Class I Signup and view all the answers

How do CD4 and CD8 co-receptors contribute to TCR-pMHC interaction?

Enhance the specificity of the interaction Signup and view all the answers

Which molecule must bind a peptide first to be represented on the cell surface?

MHC Signup and view all the answers

What is a general feature shared by all MHC molecules?

Consisting of several Immunoglobulin (Ig)-like domains Signup and view all the answers

Which cells are types of lymphocytes that arise in the thymus from bone-marrow progenitors?

T cells Signup and view all the answers

What is a key requirement for T cell recognition of antigens?

Recognition of MHC molecules Signup and view all the answers

Which type of T cell recognizes antigens presented on MHC Class I molecules?

CD8+ T cells Signup and view all the answers

What is the main function of CD8+ T cells once activated?

Become effector Cytotoxic T Lymphocytes (CTLs) Signup and view all the answers

Which type of T cell undergoes recognition of antigens presented on MHC Class II molecules?

CD4+ T cells Signup and view all the answers

What is the primary role of the TCR complex in T cell activation?

Formation of an immunological synapse Signup and view all the answers

What are the two main types of mature T cells based on the components of their heterodimer receptors?

Alpha/beta TCR and Gamma/delta TCR Signup and view all the answers

What is the process that allows for recombination of gene segments in T cell receptor genetic loci to produce a functional gene?

Somatic recombination Signup and view all the answers

Which region(s) encode different segments of adaptive immune receptors like BCR and TCR?

Variable (V), Joining (J), and Constant (C) regions Signup and view all the answers

How do CD4+ Helper T cells differ in their subsets?

Each subset regulates different activities within the body Signup and view all the answers