Podcast
Questions and Answers
What is the process that involves T cells migrating into the lymph node?
What is the process that involves T cells migrating into the lymph node?
- Diapedesis (correct)
- Chemokine activation
- Binding adhesion molecules
- Antigen sampling
Which adhesion molecule is responsible for the weak attachment that leads to T cell rolling along the endothelial surface?
Which adhesion molecule is responsible for the weak attachment that leads to T cell rolling along the endothelial surface?
- Chemokine
- Integrin
- Adhesion molecule
- Selectin (correct)
What is the main function of fibroblastic reticular cells in the lymph nodes?
What is the main function of fibroblastic reticular cells in the lymph nodes?
- Secrete antibodies for antigen recognition
- Secrete chemokines attracting T cells and DCs (correct)
- Act as antigen-presenting cells to T cells
- Destroy pathogens in the lymph nodes
Which molecule helps naïve T cells find their matches in the lymph nodes?
Which molecule helps naïve T cells find their matches in the lymph nodes?
What is the purpose of T cells scanning for antigens once they are in the lymph node?
What is the purpose of T cells scanning for antigens once they are in the lymph node?
How do naïve CD4+ T cells behave after engaging with the Antigen:MHC complex?
How do naïve CD4+ T cells behave after engaging with the Antigen:MHC complex?
What determines the kinetics of early encounters between T cells and dendritic cells in the lymph node?
What determines the kinetics of early encounters between T cells and dendritic cells in the lymph node?
'Rolling -> Activation -> Arrest + Tight Binding -> Diapedesis -> Entering Lymph Node' represents which process in T cell migration?
'Rolling -> Activation -> Arrest + Tight Binding -> Diapedesis -> Entering Lymph Node' represents which process in T cell migration?
'DCs can be surveyed by more than 5000 T cells per hour!' implies what about the interaction between dendritic cells and T cells?
'DCs can be surveyed by more than 5000 T cells per hour!' implies what about the interaction between dendritic cells and T cells?
Which segment types are needed to make a T cell receptor?
Which segment types are needed to make a T cell receptor?
What is the role of professional antigen-presenting cells?
What is the role of professional antigen-presenting cells?
Which type of MHC molecules bind peptides of endogenous origin?
Which type of MHC molecules bind peptides of endogenous origin?
How do CD4 and CD8 co-receptors contribute to TCR-pMHC interaction?
How do CD4 and CD8 co-receptors contribute to TCR-pMHC interaction?
Which molecule must bind a peptide first to be represented on the cell surface?
Which molecule must bind a peptide first to be represented on the cell surface?
What is a general feature shared by all MHC molecules?
What is a general feature shared by all MHC molecules?
Which cells are types of lymphocytes that arise in the thymus from bone-marrow progenitors?
Which cells are types of lymphocytes that arise in the thymus from bone-marrow progenitors?
What is a key requirement for T cell recognition of antigens?
What is a key requirement for T cell recognition of antigens?
Which type of T cell recognizes antigens presented on MHC Class I molecules?
Which type of T cell recognizes antigens presented on MHC Class I molecules?
What is the main function of CD8+ T cells once activated?
What is the main function of CD8+ T cells once activated?
Which type of T cell undergoes recognition of antigens presented on MHC Class II molecules?
Which type of T cell undergoes recognition of antigens presented on MHC Class II molecules?
What is the primary role of the TCR complex in T cell activation?
What is the primary role of the TCR complex in T cell activation?
What are the two main types of mature T cells based on the components of their heterodimer receptors?
What are the two main types of mature T cells based on the components of their heterodimer receptors?
What is the process that allows for recombination of gene segments in T cell receptor genetic loci to produce a functional gene?
What is the process that allows for recombination of gene segments in T cell receptor genetic loci to produce a functional gene?
Which region(s) encode different segments of adaptive immune receptors like BCR and TCR?
Which region(s) encode different segments of adaptive immune receptors like BCR and TCR?
How do CD4+ Helper T cells differ in their subsets?
How do CD4+ Helper T cells differ in their subsets?
