B cell lecture 1

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What type of antigens do not require T cell helpers?

Peptides

Polysaccharides (correct)

LPS

Proteins

Which cell provides help to B cells in Signal 2?

T FH cell (correct)

Memory B cell

Macrophage

NK cell

Which signaling pathway provides Signal 2 to some B cells?

JAK/STAT signaling

NF-kB signaling

MAPK signaling

TLR signaling (correct)

What is the role of IL21 in B cell biology?

Trigger survival and proliferation Signup and view all the answers

Which molecule cross-links on the BCR and is mentioned as a highly repetitive molecule?

LPS Signup and view all the answers

What happens when CD40 on B cells binds to CD40L on T FH cells?

Results in signaling & activation of transcription factors Signup and view all the answers

What is the rule of linked recognition between B and T FH cells?

Epitopes recognized must be derived from the same antigen Signup and view all the answers

'Linked recognition' differs between T cells and B cells in that B cells can:

Recognize structural epitopes of each other Signup and view all the answers

What is the function of plasma cells?

Secrete antibodies Signup and view all the answers

What happens to B cells that do not receive a survival signal?

They undergo apoptosis Signup and view all the answers

Where are B cells stored?

Bone marrow Signup and view all the answers

How do antigens enter the lymph node?

Transported by activated conventional DCs Signup and view all the answers

Which cell type retains antigens in the lymph node subcapsular sinus?

Macrophage Signup and view all the answers

What receptors are expressed by B cells when binding antigens?

CD19 and CD21 Signup and view all the answers

Which outcome is NOT triggered by phosphorylation of ITAM motifs on Iga and Igb?

Inhibition of gene transcription Signup and view all the answers

What is the function of activated Th-follicular helper (T FH) cells?

Provide Signal 2 for thymus-dependent antigens Signup and view all the answers

What is the main role of TFH cells in the context of B cell activation?

Produce cytokines for B cell survival Signup and view all the answers

Which molecule provides Signal 1 in the activation of B cells?

p:BCR Signup and view all the answers

In the context of antibody production, what is the function of plasmablasts?

Are the main antibody-secreting cells Signup and view all the answers

What type of immunity do antibodies promote through functions like Opsonization and Complement Activation?

Humoral Immunity Signup and view all the answers

Which type of cytokines do TFH cells secrete to help activate B cells?

IL-21 and IL-17 Signup and view all the answers

What is the main function of B cells in adaptive immunity?

Recognize antigens and produce antibodies Signup and view all the answers

Which molecule allows TFH cells to interact with B cells through TCR signaling?

TCR:pMHCII Signup and view all the answers

In the clonal selection theory, what happens to activated B cells?

They undergo proliferation & differentiation Signup and view all the answers

How do plasma cells differ from plasmablasts in antibody production?

Plasma cells are long-lived and continuously produce antibodies, while plasmablasts have a shorter lifespan. Signup and view all the answers

Which class of antibodies serves as a receptor on naive B cells?

IgM Signup and view all the answers