10 Questions
What is the main function of dendritic cells once they are in the lymph node?
Activate naïve T cells
Which of the following is NOT one of the 3 SIGNALS needed for T cell differentiation from naive to effector cells?
PD-1 receptors
What happens to the expression of pattern recognition receptors (PRRs) in dendritic cells once they are activated?
They are downregulated
Which DC type has very high levels of PRRs and is capable of producing a lot of type I interferon (IFN)?
Plasmacytoid DCs
How do T cells enter the lymph node?
Via afferent lymphatics
What is the main role of tissue-resident macrophages with DC morphology when conventional DCs are absent?
Initiate antigen uptake and transport
What happens if a T cell does not encounter its specific antigen in the lymph node?
It leaves via efferent lymphatics
Which blood vessels do T and B cells use to enter the lymph node?
High Endothelial Venules (HEV)
What is the main function of effector T cells in the immune response?
Activate other immune cells
If a transfer of antigens to resident dendritic cells occurs in the lymph node, what may be the reason for this?
Presence of certain viruses that kill phagocytic dendritic cells before antigen uptake
Learn about how dendritic cells travel from the site of infection to lymphoid tissue, where they activate T cells through a series of steps. Understand the process of DCs binding to PAMPs via PRRs, expressing receptors targeting them to lymph nodes, and activating naive T cells by providing the necessary signals.
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