Lecture 11: Moving to the Lymph Node
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Questions and Answers

What is the main function of dendritic cells once they are in the lymph node?

  • Phagocytose antigens
  • Secrete cytokines
  • Activate naïve T cells (correct)
  • Activate B cells
  • Which of the following is NOT one of the 3 SIGNALS needed for T cell differentiation from naive to effector cells?

  • Peptide and MHC molecule with specific TCR
  • PD-1 receptors (correct)
  • B7.1 + B7.2 and CD28 molecules
  • Cytokines
  • What happens to the expression of pattern recognition receptors (PRRs) in dendritic cells once they are activated?

  • They become inactive
  • They remain unchanged
  • They are upregulated
  • They are downregulated (correct)
  • Which DC type has very high levels of PRRs and is capable of producing a lot of type I interferon (IFN)?

    <p>Plasmacytoid DCs</p> Signup and view all the answers

    How do T cells enter the lymph node?

    <p>Via afferent lymphatics</p> Signup and view all the answers

    What is the main role of tissue-resident macrophages with DC morphology when conventional DCs are absent?

    <p>Initiate antigen uptake and transport</p> Signup and view all the answers

    What happens if a T cell does not encounter its specific antigen in the lymph node?

    <p>It leaves via efferent lymphatics</p> Signup and view all the answers

    Which blood vessels do T and B cells use to enter the lymph node?

    <p>High Endothelial Venules (HEV)</p> Signup and view all the answers

    What is the main function of effector T cells in the immune response?

    <p>Activate other immune cells</p> Signup and view all the answers

    If a transfer of antigens to resident dendritic cells occurs in the lymph node, what may be the reason for this?

    <p>Presence of certain viruses that kill phagocytic dendritic cells before antigen uptake</p> Signup and view all the answers

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