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Questions and Answers
Positive selection in the cortex is a key event in B cell maturation.
Positive selection in the cortex is a key event in B cell maturation.
False
Chemokine-guided migration of B cells occurs during lymphocyte maturation.
Chemokine-guided migration of B cells occurs during lymphocyte maturation.
False
Negative selection in the medulla is a process involved in T cell survival.
Negative selection in the medulla is a process involved in T cell survival.
False
Selection and elimination occur at checkpoints as key events in B cell maturation.
Selection and elimination occur at checkpoints as key events in B cell maturation.
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Actions of the Pre-T cell receptor are essential for B cell development in the thymus.
Actions of the Pre-T cell receptor are essential for B cell development in the thymus.
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Positive selection in the cortex ensures that only B cells with non-functional receptors undergo apoptosis.
Positive selection in the cortex ensures that only B cells with non-functional receptors undergo apoptosis.
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Chemokine-guided migration of T cells only occurs during negative selection in the medulla.
Chemokine-guided migration of T cells only occurs during negative selection in the medulla.
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Negative selection in the medulla leads to the elimination of T cells that recognize self-antigens too strongly.
Negative selection in the medulla leads to the elimination of T cells that recognize self-antigens too strongly.
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T cell survival is promoted by apoptosis.
T cell survival is promoted by apoptosis.
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Lymphocyte maturation involves a random series of events that results in a limited range of diverse lymphocytes.
Lymphocyte maturation involves a random series of events that results in a limited range of diverse lymphocytes.
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Positive selection is a crucial step in the maturation of B cells in the bone marrow.
Positive selection is a crucial step in the maturation of B cells in the bone marrow.
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Positive selection promotes survival of lymphocytes with strong interactions with self-antigens.
Positive selection promotes survival of lymphocytes with strong interactions with self-antigens.
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Negative selection eliminates T cells that bind weakly to self-antigens.
Negative selection eliminates T cells that bind weakly to self-antigens.
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Clonal deletion occurs during positive selection.
Clonal deletion occurs during positive selection.
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Actions of the pre-T cell receptor are involved in B cell maturation.
Actions of the pre-T cell receptor are involved in B cell maturation.
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During maturation, immature B cells may initially express two versions of the antigen receptor, one from each chromosome.
During maturation, immature B cells may initially express two versions of the antigen receptor, one from each chromosome.
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The pre-BCR promotes allelic exclusion during B cell maturation.
The pre-BCR promotes allelic exclusion during B cell maturation.
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T cell maturation involves chemokine-guided migration to the thymus.
T cell maturation involves chemokine-guided migration to the thymus.
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During B cell maturation, the expression of surrogate light chains continues in mature B cells.
During B cell maturation, the expression of surrogate light chains continues in mature B cells.
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One key event in T cell maturation is sequential rearrangement.
One key event in T cell maturation is sequential rearrangement.
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Positive selection in the cortex is a key event in T cell maturation.
Positive selection in the cortex is a key event in T cell maturation.
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Chemokine-guided migration of B cells occurs during lymphocyte maturation.
Chemokine-guided migration of B cells occurs during lymphocyte maturation.
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Negative selection in the medulla is a process involved in T cell survival.
Negative selection in the medulla is a process involved in T cell survival.
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T cell survival and apoptosis are regulated by the actions of the Pre-B cell receptor.
T cell survival and apoptosis are regulated by the actions of the Pre-B cell receptor.
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Lymphocyte maturation involves selection and elimination as key events in B cell maturation.
Lymphocyte maturation involves selection and elimination as key events in B cell maturation.
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Receptor editing in B cells provides a mechanism to modify antigen receptor specificity and avoid autoreactivity.
Receptor editing in B cells provides a mechanism to modify antigen receptor specificity and avoid autoreactivity.
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T cell survival with strong reactivity to self-antigens is promoted by negative selection.
T cell survival with strong reactivity to self-antigens is promoted by negative selection.
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B cell maturation involves three rounds of sequential rearrangement of immunoglobulin (Ig) genes.
B cell maturation involves three rounds of sequential rearrangement of immunoglobulin (Ig) genes.
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Key events in T cell maturation include sequential rearrangement of immunoglobulin genes.
Key events in T cell maturation include sequential rearrangement of immunoglobulin genes.
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Lymphocyte maturation ensures the generation of dysfunctional B cells incapable of recognizing antigens.
Lymphocyte maturation ensures the generation of dysfunctional B cells incapable of recognizing antigens.
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Positive selection in the cortex is a key event in T cell maturation.
Positive selection in the cortex is a key event in T cell maturation.
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Chemokine-guided migration of T cells occurs during positive selection in the medulla.
Chemokine-guided migration of T cells occurs during positive selection in the medulla.
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Negative selection in the medulla is a process involved in promoting T cell survival.
Negative selection in the medulla is a process involved in promoting T cell survival.
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T cell survival is promoted by apoptosis.
T cell survival is promoted by apoptosis.
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Lymphocyte maturation involves a random series of events that results in a limited range of diverse lymphocytes.
Lymphocyte maturation involves a random series of events that results in a limited range of diverse lymphocytes.
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Selection and elimination occur at checkpoints as key events in T cell maturation.
Selection and elimination occur at checkpoints as key events in T cell maturation.
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Actions of the Pre-B cell receptor are essential for T cell development in the thymus.
Actions of the Pre-B cell receptor are essential for T cell development in the thymus.
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Key events in T cell maturation involve changes in surface marker expression.
Key events in T cell maturation involve changes in surface marker expression.
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Actions of the Pre-T cell receptor take place during B cell development in the thymus.
Actions of the Pre-T cell receptor take place during B cell development in the thymus.
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T cell development in the thymus involves rearrangement of antigen receptor genes in a stepwise manner.
T cell development in the thymus involves rearrangement of antigen receptor genes in a stepwise manner.
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