T Cell Activation and Inhibition Pathways

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What is the function of CTLA-4 during T cell activation?

Activates TCR signaling

Triggers cell cycle progression

Promotes T cell proliferation

Inhibits T cell proliferation (correct)

Which molecule leads to cell cycle arrest during T cell activation?

CD25

CD40L

CTLA-4 (correct)

PD-1

What happens after 3 days of T cell expansion regarding proliferation?

Proliferation stops

Proliferation becomes uncontrolled

Proliferation accelerates

Proliferation slows down (correct)

Which molecule is involved in the formation of Effector Memory T cells (TEM)?

CCR7- Signup and view all the answers

What role does PD-1 play in T cell activation?

Leads to phosphatase activation Signup and view all the answers

Which molecule is responsible for promoting cytotoxicity in T cells?

IL-2 Signup and view all the answers

What is the function of CD40L during T cell activation?

Triggers B7 molecule expression on DCs Signup and view all the answers

Which signaling molecule downstream of the TCR leads to T cell activation?

ZAP-70 Signup and view all the answers

What is the role of B7 in T cell activation?

Activating DC maturation Signup and view all the answers

Which molecule initiates the Ras pathway in T cell signaling?

Ras-GTP Signup and view all the answers

What is the function of NFAT in T cell activation?

Enhancing transcription of IL-2 genes Signup and view all the answers

Which enzyme is responsible for removing inhibitory phosphates from NFAT during T cell activation?

Calcineurin Signup and view all the answers

What is the primary outcome of clonal expansion in T cell activation?

Proliferation of T cells Signup and view all the answers

Which molecule is responsible for activating PKC in T cell signaling?

Calcium ions Signup and view all the answers

What is the function of AP-1 in T cell activation signaling?

Upregulating IL-2 production Signup and view all the answers

Which enzyme is activated by Lck and leads to the activation of Ras pathway in T cell signaling?

ZAP-70 Signup and view all the answers

What is the role of CD28 receptor in T cell activation signaling?

Promoting ZAP-70 activity Signup and view all the answers