T Cell Activation and Inhibition Pathways
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Questions and Answers

What is the function of CTLA-4 during T cell activation?

  • Activates TCR signaling
  • Triggers cell cycle progression
  • Promotes T cell proliferation
  • Inhibits T cell proliferation (correct)

    • Which molecule leads to cell cycle arrest during T cell activation?

  • CD25
  • CD40L
  • CTLA-4 (correct)
  • PD-1

    • What happens after 3 days of T cell expansion regarding proliferation?

  • Proliferation stops
  • Proliferation becomes uncontrolled
  • Proliferation accelerates
  • Proliferation slows down (correct)

    • Which molecule is involved in the formation of Effector Memory T cells (TEM)?

    <p>CCR7- (A)</p> Signup and view all the answers

    What role does PD-1 play in T cell activation?

    <p>Leads to phosphatase activation (B)</p> Signup and view all the answers

    Which molecule is responsible for promoting cytotoxicity in T cells?

    <p>IL-2 (B)</p> Signup and view all the answers

    What is the function of CD40L during T cell activation?

    <p>Triggers B7 molecule expression on DCs (A)</p> Signup and view all the answers

    Which signaling molecule downstream of the TCR leads to T cell activation?

    <p>ZAP-70 (C)</p> Signup and view all the answers

    What is the role of B7 in T cell activation?

    <p>Activating DC maturation (C)</p> Signup and view all the answers

    Which molecule initiates the Ras pathway in T cell signaling?

    <p>Ras-GTP (B)</p> Signup and view all the answers

    What is the function of NFAT in T cell activation?

    <p>Enhancing transcription of IL-2 genes (B)</p> Signup and view all the answers

    Which enzyme is responsible for removing inhibitory phosphates from NFAT during T cell activation?

    <p>Calcineurin (B)</p> Signup and view all the answers

    What is the primary outcome of clonal expansion in T cell activation?

    <p>Proliferation of T cells (B)</p> Signup and view all the answers

    Which molecule is responsible for activating PKC in T cell signaling?

    <p>Calcium ions (D)</p> Signup and view all the answers

    What is the function of AP-1 in T cell activation signaling?

    <p>Upregulating IL-2 production (A)</p> Signup and view all the answers

    Which enzyme is activated by Lck and leads to the activation of Ras pathway in T cell signaling?

    <p>ZAP-70 (A)</p> Signup and view all the answers

    What is the role of CD28 receptor in T cell activation signaling?

    <p>Promoting ZAP-70 activity (A)</p> Signup and view all the answers

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