Podcast
Questions and Answers
What is the role of ligand binding to the ECDs of EGFR receptors?
What is the role of ligand binding to the ECDs of EGFR receptors?
- Causing receptor stabilization (correct)
- Communicating with the intracellular domains of the receptor
- Inducing cell differentiation
- Initiating biased signaling
Which EGFR family member is an orphan receptor and does not recognize multiple ligands?
Which EGFR family member is an orphan receptor and does not recognize multiple ligands?
- EGFR
- HER3
- HER2 (correct)
- HER4
How do different EGFR ligands, such as EGF and TGFa, affect a cell?
How do different EGFR ligands, such as EGF and TGFa, affect a cell?
- Promoting proliferation (correct)
- Causing receptor dimerization
- Stimulating differentiation
- Inducing biased signaling
What is the consequence of weakened dimerization of EGFR induced by Epiregulin and epigen?
What is the consequence of weakened dimerization of EGFR induced by Epiregulin and epigen?
In what way do different EGFR ligands stabilize receptor dimers?
In what way do different EGFR ligands stabilize receptor dimers?
What is the mechanism through which the ECD dimer communicates with the intracellular domains of the receptor?
What is the mechanism through which the ECD dimer communicates with the intracellular domains of the receptor?
Which type of dimers can be formed by EGFR family members with HER2?
Which type of dimers can be formed by EGFR family members with HER2?
Biased signaling is associated with the response of different EGFR ligands in a cell. What type of response is observed due to this biased signaling?
Biased signaling is associated with the response of different EGFR ligands in a cell. What type of response is observed due to this biased signaling?
What is the role of the adaptor protein GRB2 in the RTK-Ras/MAP kinase signaling pathway?
What is the role of the adaptor protein GRB2 in the RTK-Ras/MAP kinase signaling pathway?
In the RTK-Ras/MAP kinase signaling pathway, what is the function of Sos protein?
In the RTK-Ras/MAP kinase signaling pathway, what is the function of Sos protein?
What is the consequence of Ras activation in the RTK-Ras/MAP kinase signaling pathway?
What is the consequence of Ras activation in the RTK-Ras/MAP kinase signaling pathway?
Which kinase is phosphorylated and activated by MAP kinase in the cytoplasm during RTK-Ras/MAP kinase signaling?
Which kinase is phosphorylated and activated by MAP kinase in the cytoplasm during RTK-Ras/MAP kinase signaling?
What is the role of ternary complex factor (TCF) and serum response factor (SRF) in the RTK-Ras/MAP kinase signaling pathway?
What is the role of ternary complex factor (TCF) and serum response factor (SRF) in the RTK-Ras/MAP kinase signaling pathway?
What is the function of MAP kinase in the RTK-Ras/MAP kinase signaling pathway?
What is the function of MAP kinase in the RTK-Ras/MAP kinase signaling pathway?
Which sequence controls genes, such as c-fos, that propel cells through the cell cycle?
Which sequence controls genes, such as c-fos, that propel cells through the cell cycle?
What is the consequence of Ras activation in relation to Raf kinase in the RTK-Ras/MAP kinase signaling pathway?
What is the consequence of Ras activation in relation to Raf kinase in the RTK-Ras/MAP kinase signaling pathway?
What is the term for the formation that exposes a dimerization arm in subdomain II, thereby facilitating dimerization of the extracellular region?
What is the term for the formation that exposes a dimerization arm in subdomain II, thereby facilitating dimerization of the extracellular region?
What process assumes a time lag between initial receptor ligand binding and phosphorylation of tyrosines?
What process assumes a time lag between initial receptor ligand binding and phosphorylation of tyrosines?
What is the main outcome of stable complexes according to the text?
What is the main outcome of stable complexes according to the text?
What occurs when non-stable complexes fall apart prior to activation of negative feedback?
What occurs when non-stable complexes fall apart prior to activation of negative feedback?
What creates docking sites for numerous signaling effectors?
What creates docking sites for numerous signaling effectors?
Which ligands differenstimulate ErbB4 coupling to survival and proliferation in CEM/ formation?
Which ligands differenstimulate ErbB4 coupling to survival and proliferation in CEM/ formation?
What leads to the activation of a negative feedback event?
What leads to the activation of a negative feedback event?
What is denoted by putative sites of EGFR, ErbB2, ErbB3, and ErbB4 tyrosine phosphorylation?
What is denoted by putative sites of EGFR, ErbB2, ErbB3, and ErbB4 tyrosine phosphorylation?
What is the term used for the model that assumes a time lag between initial receptor ligand binding and phosphorylation of tyrosines?
What is the term used for the model that assumes a time lag between initial receptor ligand binding and phosphorylation of tyrosines?
