Systemic Sclerosis and Raynaud's Phenomenon Quiz
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Questions and Answers

Which of the following is a characteristic skin change seen in Systemic Sclerosis at later stages?

  • Thickening of rete ridges
  • Presence of inflammatory cells
  • Increased density of blood vessels
  • Loss of secondary skin structures (correct)
  • What is a common gastrointestinal manifestation of Systemic Sclerosis?

  • Muscularis hypertrophy
  • Intimal thickening of interlobular arteries (correct)
  • Hyperplasia of the lower esophageal sphincter
  • Increased LES tone
  • Which antibody is associated with interstitial lung disease and non-erosive arthritis in Dermatomyositis?

  • Anti topoisomerase I (anti-Scl 70)
  • Anticentromere antibody
  • Anti-RNA polymerase III antibody
  • Anti-Jo1 antibody (correct)
  • In Dermatomyositis, which cell type is commonly found staining positive in muscle biopsies?

    <p>CD4+ T-helper cells</p> Signup and view all the answers

    Which color phase is typically seen FIRST in an attack of Raynaud's phenomenon associated with Systemic Sclerosis?

    <p>Pallor</p> Signup and view all the answers

    Which inflammatory cells predominate in the skin of patients with Systemic Sclerosis?

    <p>CD4+ T cells</p> Signup and view all the answers

    Which cytokine is involved in fibroblast activation and increasing collagen deposition in Systemic Sclerosis?

    <p>Platelet-Derived Growth Factor (PDGF)</p> Signup and view all the answers

    Which of the following is a characteristic feature of the skin in Systemic Sclerosis?

    <p>Basal lamina thinning and endothelial damage</p> Signup and view all the answers

    Which of the following is a component of CREST syndrome, a limited type of Systemic Sclerosis?

    <p>Raynaud's phenomenon</p> Signup and view all the answers

    What is the characteristic appearance of skin in Systemic Sclerosis that involves tightly bound dermis to subcutaneous structures, compact collagen increase, and thinning of epidermis?

    <p>Increased fibrosis and compact collagen deposition</p> Signup and view all the answers

    Which morphological classification of lupus nephritis involves minimal mesangial involvement?

    <p>Class I</p> Signup and view all the answers

    In systemic lupus erythematosus (SLE), where are the immune complexes deposited in the kidneys?

    <p>Mesangium or entire basement membrane</p> Signup and view all the answers

    Which skin manifestation is commonly seen in SLE patients upon sunlight exposure?

    <p>Butterfly rash (malar)</p> Signup and view all the answers

    In systemic lupus erythematosus, which histological feature is characteristic of skin biopsies?

    <p>Fibrinoid necrosis</p> Signup and view all the answers

    Which morphological classification of lupus nephritis presents with diffuse thickening of capillary walls?

    <p>Class IV</p> Signup and view all the answers

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