Podcast
Questions and Answers
In a canine patient presenting with a suspected uncomplicated lower urinary tract infection (UTI), which of the following factors should be given LEAST consideration when selecting an appropriate antibiotic, assuming susceptibility is confirmed for all choices?
In a canine patient presenting with a suspected uncomplicated lower urinary tract infection (UTI), which of the following factors should be given LEAST consideration when selecting an appropriate antibiotic, assuming susceptibility is confirmed for all choices?
- The antibiotic's spectrum of activity against common urinary pathogens like _E. coli_ and _Staphylococcus_.
- The cost of the antibiotic, balancing efficacy with the client's financial constraints.
- The tissue penetration capabilities of the antibiotic to ensure effective concentrations in the renal parenchyma. (correct)
- The frequency of administration and ease of administration, with preference for once-daily dosing.
An 8-year-old cat presents with lethargy, inappetence, a temperature of 104.7°F, mild dehydration, and a small ulcerative lesion below the lower left mandibular P4 with ulcers on the edge of the tongue. CBC results show a normal white count with a mild left shift and toxic neutrophils. Chemistry reveals a mildly icteric serum with a moderately increased total bilirubin and a mild increase in BUN. Urinalysis has a specific gravity of >1.060 with trace bilirubin. Considering the diagnostic workup, which of the following antibiotic choices would be MOST appropriate?
An 8-year-old cat presents with lethargy, inappetence, a temperature of 104.7°F, mild dehydration, and a small ulcerative lesion below the lower left mandibular P4 with ulcers on the edge of the tongue. CBC results show a normal white count with a mild left shift and toxic neutrophils. Chemistry reveals a mildly icteric serum with a moderately increased total bilirubin and a mild increase in BUN. Urinalysis has a specific gravity of >1.060 with trace bilirubin. Considering the diagnostic workup, which of the following antibiotic choices would be MOST appropriate?
- Cefovecin
- Azithromycin
- Clavamox
- Enrofloxacin (correct)
In a dog diagnosed with pyelonephritis, which of the following statements regarding antibiotic selection is MOST accurate?
In a dog diagnosed with pyelonephritis, which of the following statements regarding antibiotic selection is MOST accurate?
- Fluoroquinolones are often chosen due to their excellent tissue penetration and broad-spectrum activity. (correct)
- Aminoglycosides are the preferred first-line treatment due to their concentration-dependent killing and synergistic effects.
- Macrolides are the most effective antibiotics because of their anti-inflammatory and immunomodulatory properties.
- Penicillins are the ideal choice because of their safety profile.
An 18.5-year-old FS DSH cat presents with a history of CKD (stage 2), systemic hypertension, diminished appetite over the past 6 months, and recent inappetence. Physical exam reveals a BCS of 2/9, moderate to severe muscle loss, small, irregularly shaped, painful kidneys on palpation, and moderate dehydration (8%). CBC shows mild elevations in segmented neutrophils and monocytes. Chemistry shows an elevated total protein (8.9 g/dL) and globulin (5.2 g/dL), and mildly decreased alanine transaminase (27 U/L). Urinalysis reveals a specific gravity of 1.013 and many bacilli. Which of the following findings would be MOST concerning in this case?
An 18.5-year-old FS DSH cat presents with a history of CKD (stage 2), systemic hypertension, diminished appetite over the past 6 months, and recent inappetence. Physical exam reveals a BCS of 2/9, moderate to severe muscle loss, small, irregularly shaped, painful kidneys on palpation, and moderate dehydration (8%). CBC shows mild elevations in segmented neutrophils and monocytes. Chemistry shows an elevated total protein (8.9 g/dL) and globulin (5.2 g/dL), and mildly decreased alanine transaminase (27 U/L). Urinalysis reveals a specific gravity of 1.013 and many bacilli. Which of the following findings would be MOST concerning in this case?
A veterinarian is treating a dog with a suspected methicillin-resistant Staphylococcus aureus (MRSA) infection. Which of the following antibiotics would be the LEAST appropriate choice for empirical treatment, pending culture and sensitivity results?
A veterinarian is treating a dog with a suspected methicillin-resistant Staphylococcus aureus (MRSA) infection. Which of the following antibiotics would be the LEAST appropriate choice for empirical treatment, pending culture and sensitivity results?
A dog presents with a chronic, recurrent urinary tract infection (UTI). Previous cultures have identified multi-drug resistant E. coli. Which of the following strategies demonstrates the BEST antimicrobial stewardship concerning the systemic treatment?
A dog presents with a chronic, recurrent urinary tract infection (UTI). Previous cultures have identified multi-drug resistant E. coli. Which of the following strategies demonstrates the BEST antimicrobial stewardship concerning the systemic treatment?
A 4-month-old kitten presents with serous nasal and ocular discharge, sneezing and a mild decrease in appetite after being adopted from an animal shelter 3 days prior. Recognizing that viral upper respiratory infections (URIs) are common in this age group, which of the following considerations should MOST influence the decision to initiate systemic antibiotic therapy?
A 4-month-old kitten presents with serous nasal and ocular discharge, sneezing and a mild decrease in appetite after being adopted from an animal shelter 3 days prior. Recognizing that viral upper respiratory infections (URIs) are common in this age group, which of the following considerations should MOST influence the decision to initiate systemic antibiotic therapy?
In a canine patient exhibiting signs of sepsis secondary to a suspected bacterial infection, which statement BEST describes the importance of proper antibiotic administration?
In a canine patient exhibiting signs of sepsis secondary to a suspected bacterial infection, which statement BEST describes the importance of proper antibiotic administration?
Which of the following statements BEST describes the appropriate use of antibiotics in a patient diagnosed with Feline Idiopathic Cystitis (FIC)?
Which of the following statements BEST describes the appropriate use of antibiotics in a patient diagnosed with Feline Idiopathic Cystitis (FIC)?
A 5-year-old Chesapeake Bay Retriever presents with a 3-day history of large bowel diarrhea and vomiting; its TPR is significant for a temperature of 102.4 F. On a rectal exam, frank blood is present. Fecal smear reveals dysbiosis. CBC shows slight elevation in hematocrit and total protein. A snap Giardia test comes back negative. Which of the following would be the BEST next step?
A 5-year-old Chesapeake Bay Retriever presents with a 3-day history of large bowel diarrhea and vomiting; its TPR is significant for a temperature of 102.4 F. On a rectal exam, frank blood is present. Fecal smear reveals dysbiosis. CBC shows slight elevation in hematocrit and total protein. A snap Giardia test comes back negative. Which of the following would be the BEST next step?
A 3-year-old dog presents with a superficial pyoderma characterized by erythematous macules and papules. Cytology reveals cocci. Which of the following antibiotics is the MOST appropriate choice for initial treatment?
A 3-year-old dog presents with a superficial pyoderma characterized by erythematous macules and papules. Cytology reveals cocci. Which of the following antibiotics is the MOST appropriate choice for initial treatment?
When selecting an antibiotic for treating a bacterial infection, what is the priority in ensuring responsible antimicrobial use?
When selecting an antibiotic for treating a bacterial infection, what is the priority in ensuring responsible antimicrobial use?
A 10-year-old dog presents with a history of recurrent skin infections. Previous culture and sensitivity tests have revealed resistance to multiple antibiotics, including beta-lactams and macrolides. Which management strategies would be MOST important regarding long-term care?
A 10-year-old dog presents with a history of recurrent skin infections. Previous culture and sensitivity tests have revealed resistance to multiple antibiotics, including beta-lactams and macrolides. Which management strategies would be MOST important regarding long-term care?
In which scenario is systemic antibiotic treatment for a subclinical bacteriuria MOST warranted?
In which scenario is systemic antibiotic treatment for a subclinical bacteriuria MOST warranted?
An 11-year-old Shep X presents with swelling below the left eye. On oral exam, after sedation, the clinician notices a tooth root abscess. The clinician picks at the abscess and pus begins to emerge. What is the BEST option regarding antibiotic use?
An 11-year-old Shep X presents with swelling below the left eye. On oral exam, after sedation, the clinician notices a tooth root abscess. The clinician picks at the abscess and pus begins to emerge. What is the BEST option regarding antibiotic use?
Which patient is LEAST likely to benefit from systemic antimicrobial therapy?
Which patient is LEAST likely to benefit from systemic antimicrobial therapy?
In a dog with a confirmed bacterial infection, sensitivity testing reveals resistance to multiple antibiotics. Which action aligns with responsible antimicrobial use?
In a dog with a confirmed bacterial infection, sensitivity testing reveals resistance to multiple antibiotics. Which action aligns with responsible antimicrobial use?
What best describes when a clinician should perform a culture again after a UTI?
What best describes when a clinician should perform a culture again after a UTI?
You are presented with a 6-year-old castrated male cat with a history of chronic upper respiratory infections (URI). The cat is currently exhibiting mild sneezing and serous nasal discharge. The owner is insistent on antibiotic treatment. What course of action is MOST appropriate?
You are presented with a 6-year-old castrated male cat with a history of chronic upper respiratory infections (URI). The cat is currently exhibiting mild sneezing and serous nasal discharge. The owner is insistent on antibiotic treatment. What course of action is MOST appropriate?
An owner declines radiographs, but has brought in a fecal to be sampled. Given that there is blood on the rectal glove from the exam, what would be the BEST description of what's going on?
An owner declines radiographs, but has brought in a fecal to be sampled. Given that there is blood on the rectal glove from the exam, what would be the BEST description of what's going on?
In managing a dog with a periapical tooth abscess, which statement regarding antibiotic therapy is MOST accurate?
In managing a dog with a periapical tooth abscess, which statement regarding antibiotic therapy is MOST accurate?
In a dog presenting with signs of acute bacterial prostatitis, which of the following antibiotics would be MOST appropriate choice?
In a dog presenting with signs of acute bacterial prostatitis, which of the following antibiotics would be MOST appropriate choice?
In the context of antimicrobial stewardship, which of the following actions is LEAST appropriate?
In the context of antimicrobial stewardship, which of the following actions is LEAST appropriate?
Regarding a dog that has an infected wound, what factors would be the MOST beneficial in selecting an antibiotic?
Regarding a dog that has an infected wound, what factors would be the MOST beneficial in selecting an antibiotic?
What considerations should a clinician take when they diagnose Cytauxzoonosis?
What considerations should a clinician take when they diagnose Cytauxzoonosis?
According to ISCAID recommendations, which two antibiotics are recommended as first-line?
According to ISCAID recommendations, which two antibiotics are recommended as first-line?
If one chooses to add L-lysine +/- Famciclovir for long-term use, what disease would you expect?
If one chooses to add L-lysine +/- Famciclovir for long-term use, what disease would you expect?
You see a dog that has mild lethargy, but is still eating; however, their appetite is decreased. On oral examination, you feel the mandibular feels slightly enlarged. You perform a CBC, and you note mild inflammatory leukogram. How do you proceed?
You see a dog that has mild lethargy, but is still eating; however, their appetite is decreased. On oral examination, you feel the mandibular feels slightly enlarged. You perform a CBC, and you note mild inflammatory leukogram. How do you proceed?
You are presented with a practice scenario of who wore gloves while examining the cats in order to determine the correct action. What is the CORRECT course of action?
You are presented with a practice scenario of who wore gloves while examining the cats in order to determine the correct action. What is the CORRECT course of action?
Should a veterinarian start culture 1-2 weeks after stopping antibiotic for acute pyelonephritis?
Should a veterinarian start culture 1-2 weeks after stopping antibiotic for acute pyelonephritis?
Regarding a practitioner's next goal when administering fluids, what is the ideal goal in treating the patient?
Regarding a practitioner's next goal when administering fluids, what is the ideal goal in treating the patient?
What is one of the most common bacterial causes of an upper respiratory infection (URI) in cats, as mentioned in the provided slides, and does it mean they need antibiotics?
What is one of the most common bacterial causes of an upper respiratory infection (URI) in cats, as mentioned in the provided slides, and does it mean they need antibiotics?
You are trying to decide what antibiotics to prescribe, and are faced with the options that include Liquid and Tablet antibiotic. What is the most important factor in choosing these to prescribe?
You are trying to decide what antibiotics to prescribe, and are faced with the options that include Liquid and Tablet antibiotic. What is the most important factor in choosing these to prescribe?
What is subclinical bacteriuria?
What is subclinical bacteriuria?
What is the most common cause of UTIs in dogs?
What is the most common cause of UTIs in dogs?
Should you choose costs over antimicrobial approaches?
Should you choose costs over antimicrobial approaches?
A dog presents with a suspected urinary tract infection (UTI) and the veterinarian is considering amoxicillin as a treatment option. What parameter should be given MOST consideration?
A dog presents with a suspected urinary tract infection (UTI) and the veterinarian is considering amoxicillin as a treatment option. What parameter should be given MOST consideration?
In a cat diagnosed with Feline Idiopathic Cystitis (FIC) and struvite crystalluria, but without evidence of a UTI, which of the following dietary modifications would be MOST appropriate as an initial step?
In a cat diagnosed with Feline Idiopathic Cystitis (FIC) and struvite crystalluria, but without evidence of a UTI, which of the following dietary modifications would be MOST appropriate as an initial step?
A 7-year-old FS Golden Retriever presents with a history of recurrent UTIs and is currently exhibiting clinical signs, including hematuria and dysuria. Culture and sensitivity testing reveals resistance to multiple antibiotics, but susceptibility to pradofloxacin. Which consideration regarding pradofloxacin use in this patient is MOST pertinent?
A 7-year-old FS Golden Retriever presents with a history of recurrent UTIs and is currently exhibiting clinical signs, including hematuria and dysuria. Culture and sensitivity testing reveals resistance to multiple antibiotics, but susceptibility to pradofloxacin. Which consideration regarding pradofloxacin use in this patient is MOST pertinent?
In managing a 6-year-old cat with a history of chronic upper respiratory infections (URI) and suspected feline herpesvirus-1 (FHV-1), which of the following treatment strategies would be MOST comprehensive?
In managing a 6-year-old cat with a history of chronic upper respiratory infections (URI) and suspected feline herpesvirus-1 (FHV-1), which of the following treatment strategies would be MOST comprehensive?
An 11-year-old Shep X presents with swelling below the left eye. On oral exam, after sedation, the clinician notices a tooth root abscess. After the clinician picks at the abscess, pus begins to emerge. What should the clinician do regarding systemic antibiotics?
An 11-year-old Shep X presents with swelling below the left eye. On oral exam, after sedation, the clinician notices a tooth root abscess. After the clinician picks at the abscess, pus begins to emerge. What should the clinician do regarding systemic antibiotics?
A 5-year-old FS Chesapeake Bay Retriever presents with a 3-day history of large bowel diarrhea and vomiting; its TPR is significant for a temperature of 102.4 F. On a rectal exam, frank blood is present. Fecal smear reveals dysbiosis. CBC shows slight elevation in hematocrit and total protein. A snap Giardia test comes back negative. What is the most appropriate action?
A 5-year-old FS Chesapeake Bay Retriever presents with a 3-day history of large bowel diarrhea and vomiting; its TPR is significant for a temperature of 102.4 F. On a rectal exam, frank blood is present. Fecal smear reveals dysbiosis. CBC shows slight elevation in hematocrit and total protein. A snap Giardia test comes back negative. What is the most appropriate action?
An 18.5-year-old cat presents with a history of CKD (stage 2) and systemic hypertension. CBC shows mild elevations in segmented neutrophils and monocytes. Chemistry shows elevated total protein and globulin. Urinalysis reveals a specific gravity of 1.013 and many bacilli. What finding is most concerning in this case?
An 18.5-year-old cat presents with a history of CKD (stage 2) and systemic hypertension. CBC shows mild elevations in segmented neutrophils and monocytes. Chemistry shows elevated total protein and globulin. Urinalysis reveals a specific gravity of 1.013 and many bacilli. What finding is most concerning in this case?
In a dog presenting with acute bacterial prostatitis where culture and sensitivity are pending, which of the following antibiotics would be the MOST appropriate empirical choice, considering the need for adequate prostatic tissue penetration and spectrum of activity?
In a dog presenting with acute bacterial prostatitis where culture and sensitivity are pending, which of the following antibiotics would be the MOST appropriate empirical choice, considering the need for adequate prostatic tissue penetration and spectrum of activity?
You are presented with a case to determine the correct action based on who wore gloves while examining cats. What is the CORRECT course of action?
You are presented with a case to determine the correct action based on who wore gloves while examining cats. What is the CORRECT course of action?
In a canine patient diagnosed with pyelonephritis. The bacterial culture identifies a multi-drug resistant E. coli susceptible only to amikacin. Which approach is MOST justified?
In a canine patient diagnosed with pyelonephritis. The bacterial culture identifies a multi-drug resistant E. coli susceptible only to amikacin. Which approach is MOST justified?
A 4-month-old kitten presents with serous nasal and ocular discharge, sneezing, and a mild decrease in appetite 3 days after adoption. The owner is requesting antibiotics. What factor should most influence the decision to initiate systemic antibiotic therapy?
A 4-month-old kitten presents with serous nasal and ocular discharge, sneezing, and a mild decrease in appetite 3 days after adoption. The owner is requesting antibiotics. What factor should most influence the decision to initiate systemic antibiotic therapy?
Which strategy aligns BEST with antimicrobial stewardship when a dog has a confirmed bacterial infection resistant to multiple antibiotics?
Which strategy aligns BEST with antimicrobial stewardship when a dog has a confirmed bacterial infection resistant to multiple antibiotics?
A 12 yr, FS, Australian Shep presents with a 3-day history of mildly ADR. Physical exam reveals Pollakiuria, normal TPR, and BCS 4.5/5. CBC and Chemistry results are WNL. Urinalysis reveals many rods. Which action is MOST appropriate?
A 12 yr, FS, Australian Shep presents with a 3-day history of mildly ADR. Physical exam reveals Pollakiuria, normal TPR, and BCS 4.5/5. CBC and Chemistry results are WNL. Urinalysis reveals many rods. Which action is MOST appropriate?
In a clinical setting, what is the MOST important factor in choosing to prescribe liquid and tablet antibiotics?
In a clinical setting, what is the MOST important factor in choosing to prescribe liquid and tablet antibiotics?
Which pair of antibiotics is recommended as first-line choices for uncomplicated UTIs, according to ISCAID recommendations?
Which pair of antibiotics is recommended as first-line choices for uncomplicated UTIs, according to ISCAID recommendations?
If one chooses to add L-lysine +/- Famciclovir for long-term use in a cat, what underlying condition is MOST suspected?
If one chooses to add L-lysine +/- Famciclovir for long-term use in a cat, what underlying condition is MOST suspected?
Regarding a veterinarian's next goal when administering fluids, what is the MOST important consideration in treating the patient?
Regarding a veterinarian's next goal when administering fluids, what is the MOST important consideration in treating the patient?
What key factor differentiates the diagnostic approach to pyelonephritis from a routine lower urinary tract infection (UTI)?
What key factor differentiates the diagnostic approach to pyelonephritis from a routine lower urinary tract infection (UTI)?
A dog presents with mild lethargy and a decreased appetite. On oral examination, the mandibular area feels slightly enlarged. CBC results show a mild inflammatory leukogram. What is the MOST appropriate next step?
A dog presents with mild lethargy and a decreased appetite. On oral examination, the mandibular area feels slightly enlarged. CBC results show a mild inflammatory leukogram. What is the MOST appropriate next step?
An 8-year-old MC DSH cat presents in May with lethargy, inappetence, fever, mild dehydration, and a small ulcerative lesion below the lower left mandibular P4, along with ulcers on the edge of the tongue. CBC shows a normal white count with a mild left shift and toxic neutrophils. Chemistry reveals mildly icteric serum with a moderately increased total bilirubin and a mild increase in BUN. Urinalysis has a specific gravity of >1.060. Regarding treatment, which consideration is MOST accurate?
An 8-year-old MC DSH cat presents in May with lethargy, inappetence, fever, mild dehydration, and a small ulcerative lesion below the lower left mandibular P4, along with ulcers on the edge of the tongue. CBC shows a normal white count with a mild left shift and toxic neutrophils. Chemistry reveals mildly icteric serum with a moderately increased total bilirubin and a mild increase in BUN. Urinalysis has a specific gravity of >1.060. Regarding treatment, which consideration is MOST accurate?
You have a patient that has mild lethargy, but is still eating; however, their appetite is decreased. On oral examination, you feel the mandibular feels slightly enlarged. You perform a CBC, and you note mild inflammatory leukogram. How do you proceed? Regarding Sasha, what would be the most appropriate action?
You have a patient that has mild lethargy, but is still eating; however, their appetite is decreased. On oral examination, you feel the mandibular feels slightly enlarged. You perform a CBC, and you note mild inflammatory leukogram. How do you proceed? Regarding Sasha, what would be the most appropriate action?
You see a dog that has mild lethargy, but is still eating; however, their appetite is decreased. On oral examination, you feel the mandibular feels slightly enlarged. You perform a CBC, and you note mild inflammatory leukogram. How do you proceed? (Regarding Sasha)
You see a dog that has mild lethargy, but is still eating; however, their appetite is decreased. On oral examination, you feel the mandibular feels slightly enlarged. You perform a CBC, and you note mild inflammatory leukogram. How do you proceed? (Regarding Sasha)
A dog diagnosed with pyelonephritis will likely benefit from the MOST aggressive approach to diagnostics; why is it of paramount importance to determine antimicrobial data?
A dog diagnosed with pyelonephritis will likely benefit from the MOST aggressive approach to diagnostics; why is it of paramount importance to determine antimicrobial data?
A 4 mo. DSH, M, has been adopted 3 days ago. There is serous nasal discharge. Why would it typically be inappropriate to administer antibiotics?
A 4 mo. DSH, M, has been adopted 3 days ago. There is serous nasal discharge. Why would it typically be inappropriate to administer antibiotics?
Flashcards
E. coli in canine UTIs
E. coli in canine UTIs
A common bacterium causing UTIs in dogs; approximately 50% of cases.
Antibiotic considerations
Antibiotic considerations
Spectrum, tissue penetration, resistance, severity, patient factors, safety, drug interactions, ease, frequency, cost, necessity.
Subclinical Bactiuria
Subclinical Bactiuria
Bacteria present in urine sediment without clinical signs of infection.
Pyelonephritis
Pyelonephritis
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UTI antibiotic selection basics
UTI antibiotic selection basics
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Refining UTI antibiotics
Refining UTI antibiotics
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Drugs for Sporadic cystitis
Drugs for Sporadic cystitis
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Brownian motion
Brownian motion
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ISCAID's first choice URI drugs
ISCAID's first choice URI drugs
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Common choice for abdominal issues
Common choice for abdominal issues
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Differentials to consider with nasal discharge and sneezing
Differentials to consider with nasal discharge and sneezing
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Study Notes
- These study notes cover common systemic antibiotics used in general veterinary medicine, focusing on factors to consider when choosing antibiotics and specific examples.
Common Problems Requiring Systemic Antibiotics
- Urinary tract infections.
- Wounds or abscesses.
- Otitis externa.
- Pyoderma.
- Diarrhea.
- Intestinal parasites.
- Tick-borne illnesses.
- Periodontal disease.
- Respiratory infections.
Factors to Consider When Choosing Antibiotics
- Spectrum of activity.
- Tissue penetration.
- Possibility of resistance.
- Severity of the infection.
- Age of the animal.
- Pregnancy status.
- Safety and potential side effects.
- Potential drug interactions.
- Ease of administration.
- Frequency of administration.
- Cost.
- Necessity of antibiotic use.
Common Systemic and Topical Antibiotics
- Amoxicillin/Clavulanic acid.
- Cephalexin.
- Doxycycline.
- Enrofloxacin.
- Cefpodoxime.
- Cefovecin.
- Metronidazole.
- Amoxicillin.
- Azithromycin.
- Orbifloxacin.
- Pradofloxacin.
- Clindamycin.
Antibiotic Specifics
- Amoxi/clav (Beta lactam): Gram +/-, Anaerobes +, Pseudomonas -, Frequency bid, Formulations L, T, Cost $-$$$.
- Cephalexin (Cephalosporin, 1st): Gram +, Anaerobes +, Pseudomonas -, Frequency bid-tid, Formulations C, L, T, Cost $-$$
- Doxycycline (Tetracycline): Gram +/-, Anaerobes +/-, Pseudomonas -, Frequency sid-bid, Formulations T, L, C, Inj, Cost $$-$$$.
- Enrofloxacin (Fluoroquinolone, 2nd): Gram +/-, Anaerobes +/-, Pseudomonas +/-, Frequency sid, Formulations T,L, Inj, Cost $$-$$$.
- Cefpodoxime (Cephalosporin, 3rd): Gram +, Anaerobes +/-, Pseudomonas -, Frequency sid, Formulations T, Cost $-$$$.
- Cefovecin (Cephalosporin, 3rd): Gram +/-, Anaerobes +/-, Pseudomonas -, Frequency q 2 weeks, Formulations Inj, Cost $-$$$.
- Metronidazole (Nitroimidazole): Gram -, Anaerobes +, Pseudomonas -, Frequency sid-bid, Formulations T, Inj, Cost $-$$
- Amoxicillin (Beta lactam): Gram +/-, Anaerobes +, Pseudomonas -, Frequency bid, Formulations C, L, Inj, Cost $-$$$.
- Azithromycin (Macrolide): Gram +, Anaerobes +, Pseudomonas -, Frequency sid, Formulations T, L, Cost $-$$$.
- Orbifloxacin (Fluoroquinolone, 2nd): Gram +/-, Anaerobes +/-, Pseudomonas +/-, Frequency sid, Formulations L, T, Cost $-$$$
- Pradofloxacin (Fluroquinolone, 3rd): Gram +, Anaerobes +, Pseudomonas -, Frequency sid, Formulations L, Cost $-$$
- Clindamycin (Lincosamide): Gram +, Anaerobes +, Pseudomonas -,Frequency bid,Formulations L, T, Cost $-$$
- L-liquid, T-tablet, C-capsule, Inj-injection.
Case Study 1: Honey
- 12-year-old female spayed Australian Shepherd.
- Mildly ADR(Ain't Doin' Right) for several days.
- Pollakiuria and normal TPR.
- BCS is 4.5/5.
- CBC and chemistry are within normal limits (WNL).
- Urinalysis shows many rods.
- Further considerations include urolithiasis, prostatitis, septicemia, acute pyelonephritis, kidney failure, diskospondylitis, and chronic pyelonephritis.
Common Cause of UTIs in Dogs
- E. coli is responsible in 50% of UTI cases.
Antibiotic Choices for UTIs
- Selection criteria includes whether it’s effective against the bacteria and reaches the site of infection.
- Potential choices are amoxicillin, amoxi/clav, cephalexin, cefpodoxime, and enrofloxacin.
Narrowing Down Antibiotic Choices
- Ease of administration and cost should be considered:
- Amoxicillin (bid, $-$$).
- Amoxi/clav (bid, $$-$$$).
- Cephalexin (bid, $-$$).
- Cefpodoxime (sid, $-$$).
- Enrofloxacin (sid, $$-$$$).
Determining Cephalexin Dosage & Cost
- #28 Cephalexin 600 mg chew tab costs $52.48 at the VHC.
- #28 Cephalexin 500mg caps costs $22.48 at the VHC.
Cephalexin Culture Results
Case Outcome: Honey
- The owner was called with culture results, and additional Cephalexin was prescribed for 3 weeks.
- A follow-up culture one week after the last capsule is generally not necessary if symptoms have resolved and the UTI is uncomplicated or sporadic.
- Cephalexin was effective in the case.
UTI Considerations
- Sporadic cystitis is defined as under 3 episodes per 12 months.
- Sporadic cystitis can be treated with amoxicillin or trimethoprim-sulfadiazine (TMS).
- Historically, UTI treatment was recommended for 7-14 days; newer studies suggest 3-5 days could be sufficient.
- Analgesics (NSAIDs) can be started while awaiting culture results, with antibiotics added if clinical signs persist or worsen.
- In cases of pyelonephritis, start with a fluoroquinolone for high tissue penetration.
Subclinical Bactiuria
- Characterized by bacteria in sediment but no clinical symptoms.
- Does not require treatment.
Case Study 2: Zombie
- A 4-year-old male castrated domestic shorthair cat.
- Diagnosed with a 3 day history of inappropriate urination, stranguria, periuria, and pollakiuria.
- A new kitten had been introduced to the house.
- Differential diagnoses considered were behavioral and medical (lower UTI, urolithiasis, urethritis, partial obstruction, or FIC).
PE and Diagnostics for Zombie
- PE shows a small, painful, thickened bladder.
- Has gross hematuria on the table.
- TPR is WNL.
- Resting findings on PE are WNL
- Lab results include WBC +++ on dipstick, WBC 0-5 phf, RBC TNTC, struvite crystalluria, and culture pending on UA.
Urine Sediment Analysis
- Analyzed to check for crystals
Struvite Crystalluria
- Can be seen transiently.
- Can form in sterile urine.
- Can form secondary to urinary tract infections
- Struvite stones may not dissolve completely unless treated with antibiotics if a UTI is present.
- Treatment continues until the crystals have dissolved.
Additional Consideration
- A list of conditions to consider include urolithiasis, septicemia, acute pyelonephritis, kidney failure, chronic pyelonephritis, and urethral strictures.
Zombie Outcome
- Zombie does not need antibiotics because he most likely has Feline Idiopathic Cystitis (FIC).
- FIC results from stress-induced.
- Pain medication, SQ fluids, anti-anxiety medication, and a therapeutic diet are required.
- Culture results have no growth.
Brownian Motion
- It refers to the random movement displayed by small particles that are suspended in fluids.
- It results from collisions of particles.
Case Study 3: Midnight
- An 18.5yr old female spayed cat.
- Has a history of CKD (stage 2) and systemic hypertension.
- Appetite has started to diminish and the customer is reporting sever inappetence.
PE Findings
- Body Condition Score (BCS) is 2/9 (4-5 is ideal).
- Muscle condition score is moderate to severe generalized muscle loss.
- Right and Left Kidneys are small, irregularly shaped and painful on palpation.
- Dehydration (8%) with mild-moderate constipation.
Case Study 4: Felix
- A 4-month-old male DSH that was adopted 3 days prior.
- Serous nasal and ocular discharge.
- Experiencing Sneezing.
- Maybe has a mild decrease in appetite.
- Still likes to play
- TPR is WNL
- Resting PE results are unremarkable
Case Study 5: Frankie
- A 5-year-old female spayed Chesapeake Bay Retriever
- Has 3-day history of large bowel diarrhea
- Vomited one 3 days ago and once this morning
- There is slight decrease in appetite
- The owner states Frankie is not acting herself
- Frankie got into the trash 4 days ago
- She gets on Heartgard Plus
- It's noted in the physical exam that it is hard to get the blood results with the way she is acting.
Case Study 6: Shakespeare
- An 8-year-old male castrated DSH that goes Indoors/outdoors
- Noted in the month of May
- Lethargic, inappetance past 1-2 days
- Fever 104.7
- A small, ulcerative lesion is just below the lower left mandibular P4 and ulcers on the edge of the tongue
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