5 Systemic Antibiotics in Veterinary Medicine

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Questions and Answers

In a canine patient presenting with a suspected uncomplicated lower urinary tract infection (UTI), which of the following factors should be given LEAST consideration when selecting an appropriate antibiotic, assuming susceptibility is confirmed for all choices?

  • The antibiotic's spectrum of activity against common urinary pathogens like _E. coli_ and _Staphylococcus_.
  • The cost of the antibiotic, balancing efficacy with the client's financial constraints.
  • The tissue penetration capabilities of the antibiotic to ensure effective concentrations in the renal parenchyma. (correct)
  • The frequency of administration and ease of administration, with preference for once-daily dosing.

An 8-year-old cat presents with lethargy, inappetence, a temperature of 104.7°F, mild dehydration, and a small ulcerative lesion below the lower left mandibular P4 with ulcers on the edge of the tongue. CBC results show a normal white count with a mild left shift and toxic neutrophils. Chemistry reveals a mildly icteric serum with a moderately increased total bilirubin and a mild increase in BUN. Urinalysis has a specific gravity of >1.060 with trace bilirubin. Considering the diagnostic workup, which of the following antibiotic choices would be MOST appropriate?

  • Cefovecin
  • Azithromycin
  • Clavamox
  • Enrofloxacin (correct)

In a dog diagnosed with pyelonephritis, which of the following statements regarding antibiotic selection is MOST accurate?

  • Fluoroquinolones are often chosen due to their excellent tissue penetration and broad-spectrum activity. (correct)
  • Aminoglycosides are the preferred first-line treatment due to their concentration-dependent killing and synergistic effects.
  • Macrolides are the most effective antibiotics because of their anti-inflammatory and immunomodulatory properties.
  • Penicillins are the ideal choice because of their safety profile.

An 18.5-year-old FS DSH cat presents with a history of CKD (stage 2), systemic hypertension, diminished appetite over the past 6 months, and recent inappetence. Physical exam reveals a BCS of 2/9, moderate to severe muscle loss, small, irregularly shaped, painful kidneys on palpation, and moderate dehydration (8%). CBC shows mild elevations in segmented neutrophils and monocytes. Chemistry shows an elevated total protein (8.9 g/dL) and globulin (5.2 g/dL), and mildly decreased alanine transaminase (27 U/L). Urinalysis reveals a specific gravity of 1.013 and many bacilli. Which of the following findings would be MOST concerning in this case?

<p>Elevated total protein and globulin could indicate inflammation or infection. (A)</p> Signup and view all the answers

A veterinarian is treating a dog with a suspected methicillin-resistant Staphylococcus aureus (MRSA) infection. Which of the following antibiotics would be the LEAST appropriate choice for empirical treatment, pending culture and sensitivity results?

<p>Amoxicillin (C)</p> Signup and view all the answers

A dog presents with a chronic, recurrent urinary tract infection (UTI). Previous cultures have identified multi-drug resistant E. coli. Which of the following strategies demonstrates the BEST antimicrobial stewardship concerning the systemic treatment?

<p>Performing a new culture and sensitivity test to guide antibiotic selection, considering narrow-spectrum options if effective. (A)</p> Signup and view all the answers

A 4-month-old kitten presents with serous nasal and ocular discharge, sneezing and a mild decrease in appetite after being adopted from an animal shelter 3 days prior. Recognizing that viral upper respiratory infections (URIs) are common in this age group, which of the following considerations should MOST influence the decision to initiate systemic antibiotic therapy?

<p>Systemic antibiotics are not indicated unless the kitten exhibits signs such as lethargy, fever, or purulent mucopurulent discharge. (A)</p> Signup and view all the answers

In a canine patient exhibiting signs of sepsis secondary to a suspected bacterial infection, which statement BEST describes the importance of proper antibiotic administration?

<p>Administering appropriate antibiotics intravenously as soon as possible can significantly improve survival rates in septic patients. (C)</p> Signup and view all the answers

Which of the following statements BEST describes the appropriate use of antibiotics in a patient diagnosed with Feline Idiopathic Cystitis (FIC)?

<p>Antibiotics are contraindicated in FIC unless there is a documented concurrent bacterial infection based on culture and sensitivity. (C)</p> Signup and view all the answers

A 5-year-old Chesapeake Bay Retriever presents with a 3-day history of large bowel diarrhea and vomiting; its TPR is significant for a temperature of 102.4 F. On a rectal exam, frank blood is present. Fecal smear reveals dysbiosis. CBC shows slight elevation in hematocrit and total protein. A snap Giardia test comes back negative. Which of the following would be the BEST next step?

<p>Prescribe Fenbendazole (A)</p> Signup and view all the answers

A 3-year-old dog presents with a superficial pyoderma characterized by erythematous macules and papules. Cytology reveals cocci. Which of the following antibiotics is the MOST appropriate choice for initial treatment?

<p>Cefpodoxime (C)</p> Signup and view all the answers

When selecting an antibiotic for treating a bacterial infection, what is the priority in ensuring responsible antimicrobial use?

<p>Matching the antibiotic's spectrum of activity to the specific identified pathogen and avoiding overuse of broad-spectrum agents (C)</p> Signup and view all the answers

A 10-year-old dog presents with a history of recurrent skin infections. Previous culture and sensitivity tests have revealed resistance to multiple antibiotics, including beta-lactams and macrolides. Which management strategies would be MOST important regarding long-term care?

<p>Focusing on identifying and addressing underlying causes, implementing strict topical hygiene, and using targeted topical antimicrobials based on culture and sensitivity. (A)</p> Signup and view all the answers

In which scenario is systemic antibiotic treatment for a subclinical bacteriuria MOST warranted?

<p>An immunocompromised patient is undergoing chemotherapy. (D)</p> Signup and view all the answers

An 11-year-old Shep X presents with swelling below the left eye. On oral exam, after sedation, the clinician notices a tooth root abscess. The clinician picks at the abscess and pus begins to emerge. What is the BEST option regarding antibiotic use?

<p>Appropriate antibiotic therapy is warranted due to the infection. Amoxicillin/Clavulanate would be an appropriate choice. (C)</p> Signup and view all the answers

Which patient is LEAST likely to benefit from systemic antimicrobial therapy?

<p>Zombie the cat suffering from Feline Idiopathic Cystitis (D)</p> Signup and view all the answers

In a dog with a confirmed bacterial infection, sensitivity testing reveals resistance to multiple antibiotics. Which action aligns with responsible antimicrobial use?

<p>Consulting with a veterinary infectious disease specialist to explore alternative treatment options, including combination therapy or novel antimicrobials. (D)</p> Signup and view all the answers

What best describes when a clinician should perform a culture again after a UTI?

<p>The clinician should perform a culture again 1 week after the last encapsulated dose, however the clinician should not consider the culture if the clinical signs are gone. (B)</p> Signup and view all the answers

You are presented with a 6-year-old castrated male cat with a history of chronic upper respiratory infections (URI). The cat is currently exhibiting mild sneezing and serous nasal discharge. The owner is insistent on antibiotic treatment. What course of action is MOST appropriate?

<p>Educate the owner about the primarily viral nature of most URIs, the judicious use of antibiotics, and recommend supportive care. (B)</p> Signup and view all the answers

An owner declines radiographs, but has brought in a fecal to be sampled. Given that there is blood on the rectal glove from the exam, what would be the BEST description of what's going on?

<p>Dysbiosis could be related to the issue, especially if it is coming from a large bowel. (A)</p> Signup and view all the answers

In managing a dog with a periapical tooth abscess, which statement regarding antibiotic therapy is MOST accurate?

<p>Antibiotic coverage is warranted, and Amoxicillin/Clavulanate would be an appropriate systemic choice. (D)</p> Signup and view all the answers

In a dog presenting with signs of acute bacterial prostatitis, which of the following antibiotics would be MOST appropriate choice?

<p>Enrofloxacin, based on its ability to achieve adequate concentrations in the prostate gland. (A)</p> Signup and view all the answers

In the context of antimicrobial stewardship, which of the following actions is LEAST appropriate?

<p>Prescribing broad-spectrum antibiotics as first-line therapy for most infections to ensure adequate coverage. (C)</p> Signup and view all the answers

Regarding a dog that has an infected wound, what factors would be the MOST beneficial in selecting an antibiotic?

<p>Aerobic and anaerobic culture and sensitivity testing. (D)</p> Signup and view all the answers

What considerations should a clinician take when they diagnose Cytauxzoonosis?

<p>Clinicians should not prescribe Azithromycin even though it is an option, because there is not a lot of great supportive evidence. (D)</p> Signup and view all the answers

According to ISCAID recommendations, which two antibiotics are recommended as first-line?

<p>Amoxicillin and doxycycline. (C)</p> Signup and view all the answers

If one chooses to add L-lysine +/- Famciclovir for long-term use, what disease would you expect?

<p>FHV-1. (D)</p> Signup and view all the answers

You see a dog that has mild lethargy, but is still eating; however, their appetite is decreased. On oral examination, you feel the mandibular feels slightly enlarged. You perform a CBC, and you note mild inflammatory leukogram. How do you proceed?

<p>Sedate the patient and continue to palpate. This way, if there is an infection, you will know better. (C)</p> Signup and view all the answers

You are presented with a practice scenario of who wore gloves while examining the cats in order to determine the correct action. What is the CORRECT course of action?

<p>It is important to wear gloves because Bartonella, a zoonotic disease, can be transfered during an exam. Protect yourself and your team. (A)</p> Signup and view all the answers

Should a veterinarian start culture 1-2 weeks after stopping antibiotic for acute pyelonephritis?

<p>Yes, it is needed to make sure the infection cleared. (B)</p> Signup and view all the answers

Regarding a practitioner's next goal when administering fluids, what is the ideal goal in treating the patient?

<p>The goal is to maintain proper kidney function while treating the primary infection. (C)</p> Signup and view all the answers

What is one of the most common bacterial causes of an upper respiratory infection (URI) in cats, as mentioned in the provided slides, and does it mean they need antibiotics?

<p><em>Pasteurella multocida</em>; antibiotics may be warranted depending on severity (D)</p> Signup and view all the answers

You are trying to decide what antibiotics to prescribe, and are faced with the options that include Liquid and Tablet antibiotic. What is the most important factor in choosing these to prescribe?

<p>The client must be able and willing to administer the medications as needed. (C)</p> Signup and view all the answers

What is subclinical bacteriuria?

<p>Bacteria seen in sediment, but does not require any attention. (A)</p> Signup and view all the answers

What is the most common cause of UTIs in dogs?

<p>E. coli (D)</p> Signup and view all the answers

Should you choose costs over antimicrobial approaches?

<p>Antimicrobial approaches always come before costs. (B)</p> Signup and view all the answers

A dog presents with a suspected urinary tract infection (UTI) and the veterinarian is considering amoxicillin as a treatment option. What parameter should be given MOST consideration?

<p>Known or suspected bacterial resistance patterns in the area, as amoxicillin's effectiveness is highly dependent on bacterial susceptibility. (D)</p> Signup and view all the answers

In a cat diagnosed with Feline Idiopathic Cystitis (FIC) and struvite crystalluria, but without evidence of a UTI, which of the following dietary modifications would be MOST appropriate as an initial step?

<p>Switching to a therapeutic diet that promotes increased water intake and is formulated to help dissolve struvite crystals. (D)</p> Signup and view all the answers

A 7-year-old FS Golden Retriever presents with a history of recurrent UTIs and is currently exhibiting clinical signs, including hematuria and dysuria. Culture and sensitivity testing reveals resistance to multiple antibiotics, but susceptibility to pradofloxacin. Which consideration regarding pradofloxacin use in this patient is MOST pertinent?

<p>Pradofloxacin is not labeled for use in dogs, and extralabel use should be approached cautiously, considering potential adverse effects and lack of safety data. (C)</p> Signup and view all the answers

In managing a 6-year-old cat with a history of chronic upper respiratory infections (URI) and suspected feline herpesvirus-1 (FHV-1), which of the following treatment strategies would be MOST comprehensive?

<p>Initiating supportive care, and considering L-lysine and/or famciclovir, while avoiding antibiotics unless there is strong evidence of secondary bacterial infection. (C)</p> Signup and view all the answers

An 11-year-old Shep X presents with swelling below the left eye. On oral exam, after sedation, the clinician notices a tooth root abscess. After the clinician picks at the abscess, pus begins to emerge. What should the clinician do regarding systemic antibiotics?

<p>Extract the tooth and administer antibiotics to resolve infection. (D)</p> Signup and view all the answers

A 5-year-old FS Chesapeake Bay Retriever presents with a 3-day history of large bowel diarrhea and vomiting; its TPR is significant for a temperature of 102.4 F. On a rectal exam, frank blood is present. Fecal smear reveals dysbiosis. CBC shows slight elevation in hematocrit and total protein. A snap Giardia test comes back negative. What is the most appropriate action?

<p>Administering supportive care. (C)</p> Signup and view all the answers

An 18.5-year-old cat presents with a history of CKD (stage 2) and systemic hypertension. CBC shows mild elevations in segmented neutrophils and monocytes. Chemistry shows elevated total protein and globulin. Urinalysis reveals a specific gravity of 1.013 and many bacilli. What finding is most concerning in this case?

<p>The elevated globulin with bacteria present and CKD is concerning for pyelonephritis. (C)</p> Signup and view all the answers

In a dog presenting with acute bacterial prostatitis where culture and sensitivity are pending, which of the following antibiotics would be the MOST appropriate empirical choice, considering the need for adequate prostatic tissue penetration and spectrum of activity?

<p>Enrofloxacin, due to its excellent tissue penetration and broad-spectrum activity, particularly against Gram-negative bacteria. (D)</p> Signup and view all the answers

You are presented with a case to determine the correct action based on who wore gloves while examining cats. What is the CORRECT course of action?

<p>Immediately performing hand hygiene, and if the veterinarian has any cuts, make sure the bandage is adequately covered. (C)</p> Signup and view all the answers

In a canine patient diagnosed with pyelonephritis. The bacterial culture identifies a multi-drug resistant E. coli susceptible only to amikacin. Which approach is MOST justified?

<p>Administer amikacin, ensuring appropriate hydration and renal monitoring, despite its potential nephrotoxicity, given the lack of alternatives. (A)</p> Signup and view all the answers

A 4-month-old kitten presents with serous nasal and ocular discharge, sneezing, and a mild decrease in appetite 3 days after adoption. The owner is requesting antibiotics. What factor should most influence the decision to initiate systemic antibiotic therapy?

<p>The presence of purulent or mucopurulent discharge, fever, or significant lethargy, that would indicate a secondary bacterial infection. (B)</p> Signup and view all the answers

Which strategy aligns BEST with antimicrobial stewardship when a dog has a confirmed bacterial infection resistant to multiple antibiotics?

<p>Consulting with a veterinary microbiologist or infectious disease specialist to explore alternative treatment options or strategies. (B)</p> Signup and view all the answers

A 12 yr, FS, Australian Shep presents with a 3-day history of mildly ADR. Physical exam reveals Pollakiuria, normal TPR, and BCS 4.5/5. CBC and Chemistry results are WNL. Urinalysis reveals many rods. Which action is MOST appropriate?

<p>Run a culture and sensitivity. (D)</p> Signup and view all the answers

In a clinical setting, what is the MOST important factor in choosing to prescribe liquid and tablet antibiotics?

<p>The most important factor is the efficacy against the most likely organism. (B)</p> Signup and view all the answers

Which pair of antibiotics is recommended as first-line choices for uncomplicated UTIs, according to ISCAID recommendations?

<p>Amoxicillin and trimethoprim-sulfadiazine (TMS). (C)</p> Signup and view all the answers

If one chooses to add L-lysine +/- Famciclovir for long-term use in a cat, what underlying condition is MOST suspected?

<p>Feline herpesvirus (FHV-1). (C)</p> Signup and view all the answers

Regarding a veterinarian's next goal when administering fluids, what is the MOST important consideration in treating the patient?

<p>Replacing any fluid deficits before addressing ongoing losses. (A)</p> Signup and view all the answers

What key factor differentiates the diagnostic approach to pyelonephritis from a routine lower urinary tract infection (UTI)?

<p>Pyelonephritis necessitates evaluation based on serum rather than urine antimicrobial breakpoints. (B)</p> Signup and view all the answers

A dog presents with mild lethargy and a decreased appetite. On oral examination, the mandibular area feels slightly enlarged. CBC results show a mild inflammatory leukogram. What is the MOST appropriate next step?

<p>Perform a more thorough oral exam under sedation. (A)</p> Signup and view all the answers

An 8-year-old MC DSH cat presents in May with lethargy, inappetence, fever, mild dehydration, and a small ulcerative lesion below the lower left mandibular P4, along with ulcers on the edge of the tongue. CBC shows a normal white count with a mild left shift and toxic neutrophils. Chemistry reveals mildly icteric serum with a moderately increased total bilirubin and a mild increase in BUN. Urinalysis has a specific gravity of >1.060. Regarding treatment, which consideration is MOST accurate?

<p>The cat is most likely affected by rodenticide toxicity. (B)</p> Signup and view all the answers

You have a patient that has mild lethargy, but is still eating; however, their appetite is decreased. On oral examination, you feel the mandibular feels slightly enlarged. You perform a CBC, and you note mild inflammatory leukogram. How do you proceed? Regarding Sasha, what would be the most appropriate action?

<p>A more thorough oral exam under sedation. (B)</p> Signup and view all the answers

You see a dog that has mild lethargy, but is still eating; however, their appetite is decreased. On oral examination, you feel the mandibular feels slightly enlarged. You perform a CBC, and you note mild inflammatory leukogram. How do you proceed? (Regarding Sasha)

<p>Pursue more thorough dental diagnostics. (B)</p> Signup and view all the answers

A dog diagnosed with pyelonephritis will likely benefit from the MOST aggressive approach to diagnostics; why is it of paramount importance to determine antimicrobial data?

<p>Pyelonephritis is a life-threatening disease that requires aggressive diagnostics and treatment to determine the most appropriate/effective antibiotic. (A)</p> Signup and view all the answers

A 4 mo. DSH, M, has been adopted 3 days ago. There is serous nasal discharge. Why would it typically be inappropriate to administer antibiotics?

<p>There isn't a secondary infection yet. (A)</p> Signup and view all the answers

Flashcards

E. coli in canine UTIs

A common bacterium causing UTIs in dogs; approximately 50% of cases.

Antibiotic considerations

Spectrum, tissue penetration, resistance, severity, patient factors, safety, drug interactions, ease, frequency, cost, necessity.

Subclinical Bactiuria

Bacteria present in urine sediment without clinical signs of infection.

Pyelonephritis

Inflammation of the kidney and renal pelvis, start with a fluoroquinolone.

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UTI antibiotic selection basics

  1. Does it get to infection site? 2) Does it kill bacteria?
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Refining UTI antibiotics

Ease of administration (frequency) and cost.

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Drugs for Sporadic cystitis

Amoxicillin and Trimethoprim-sulfadiazine (TMS)

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Brownian motion

It refers to the random movement displayed by small particles that are suspended in fluids.

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ISCAID's first choice URI drugs

ISCAID recommends Doxycycline or Amoxicillin as first-line choices for URI.

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Common choice for abdominal issues

Amoxi/clav, Enrofloxacin, Metronidazole, Cefovecin

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Differentials to consider with nasal discharge and sneezing

Viral URI, viral URI with secondary bacterial infection, allergies, tooth root abscess, fungal, foreign body, neoplasia

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Study Notes

  • These study notes cover common systemic antibiotics used in general veterinary medicine, focusing on factors to consider when choosing antibiotics and specific examples.

Common Problems Requiring Systemic Antibiotics

  • Urinary tract infections.
  • Wounds or abscesses.
  • Otitis externa.
  • Pyoderma.
  • Diarrhea.
  • Intestinal parasites.
  • Tick-borne illnesses.
  • Periodontal disease.
  • Respiratory infections.

Factors to Consider When Choosing Antibiotics

  • Spectrum of activity.
  • Tissue penetration.
  • Possibility of resistance.
  • Severity of the infection.
  • Age of the animal.
  • Pregnancy status.
  • Safety and potential side effects.
  • Potential drug interactions.
  • Ease of administration.
  • Frequency of administration.
  • Cost.
  • Necessity of antibiotic use.

Common Systemic and Topical Antibiotics

  • Amoxicillin/Clavulanic acid.
  • Cephalexin.
  • Doxycycline.
  • Enrofloxacin.
  • Cefpodoxime.
  • Cefovecin.
  • Metronidazole.
  • Amoxicillin.
  • Azithromycin.
  • Orbifloxacin.
  • Pradofloxacin.
  • Clindamycin.

Antibiotic Specifics

  • Amoxi/clav (Beta lactam): Gram +/-, Anaerobes +, Pseudomonas -, Frequency bid, Formulations L, T, Cost $-$$$.
  • Cephalexin (Cephalosporin, 1st): Gram +, Anaerobes +, Pseudomonas -, Frequency bid-tid, Formulations C, L, T, Cost $-$$
  • Doxycycline (Tetracycline): Gram +/-, Anaerobes +/-, Pseudomonas -, Frequency sid-bid, Formulations T, L, C, Inj, Cost $$-$$$.
  • Enrofloxacin (Fluoroquinolone, 2nd): Gram +/-, Anaerobes +/-, Pseudomonas +/-, Frequency sid, Formulations T,L, Inj, Cost $$-$$$.
  • Cefpodoxime (Cephalosporin, 3rd): Gram +, Anaerobes +/-, Pseudomonas -, Frequency sid, Formulations T, Cost $-$$$.
  • Cefovecin (Cephalosporin, 3rd): Gram +/-, Anaerobes +/-, Pseudomonas -, Frequency q 2 weeks, Formulations Inj, Cost $-$$$.
  • Metronidazole (Nitroimidazole): Gram -, Anaerobes +, Pseudomonas -, Frequency sid-bid, Formulations T, Inj, Cost $-$$
  • Amoxicillin (Beta lactam): Gram +/-, Anaerobes +, Pseudomonas -, Frequency bid, Formulations C, L, Inj, Cost $-$$$.
  • Azithromycin (Macrolide): Gram +, Anaerobes +, Pseudomonas -, Frequency sid, Formulations T, L, Cost $-$$$.
  • Orbifloxacin (Fluoroquinolone, 2nd): Gram +/-, Anaerobes +/-, Pseudomonas +/-, Frequency sid, Formulations L, T, Cost $-$$$
  • Pradofloxacin (Fluroquinolone, 3rd): Gram +, Anaerobes +, Pseudomonas -, Frequency sid, Formulations L, Cost $-$$
  • Clindamycin (Lincosamide): Gram +, Anaerobes +, Pseudomonas -,Frequency bid,Formulations L, T, Cost $-$$
  • L-liquid, T-tablet, C-capsule, Inj-injection.

Case Study 1: Honey

  • 12-year-old female spayed Australian Shepherd.
  • Mildly ADR(Ain't Doin' Right) for several days.
  • Pollakiuria and normal TPR.
  • BCS is 4.5/5.
  • CBC and chemistry are within normal limits (WNL).
  • Urinalysis shows many rods.
  • Further considerations include urolithiasis, prostatitis, septicemia, acute pyelonephritis, kidney failure, diskospondylitis, and chronic pyelonephritis.

Common Cause of UTIs in Dogs

  • E. coli is responsible in 50% of UTI cases.

Antibiotic Choices for UTIs

  • Selection criteria includes whether it’s effective against the bacteria and reaches the site of infection.
  • Potential choices are amoxicillin, amoxi/clav, cephalexin, cefpodoxime, and enrofloxacin.

Narrowing Down Antibiotic Choices

  • Ease of administration and cost should be considered:
    • Amoxicillin (bid, $-$$).
    • Amoxi/clav (bid, $$-$$$).
    • Cephalexin (bid, $-$$).
    • Cefpodoxime (sid, $-$$).
    • Enrofloxacin (sid, $$-$$$).

Determining Cephalexin Dosage & Cost

  • #28 Cephalexin 600 mg chew tab costs $52.48 at the VHC.
  • #28 Cephalexin 500mg caps costs $22.48 at the VHC.

Cephalexin Culture Results

Case Outcome: Honey

  • The owner was called with culture results, and additional Cephalexin was prescribed for 3 weeks.
  • A follow-up culture one week after the last capsule is generally not necessary if symptoms have resolved and the UTI is uncomplicated or sporadic.
  • Cephalexin was effective in the case.

UTI Considerations

  • Sporadic cystitis is defined as under 3 episodes per 12 months.
  • Sporadic cystitis can be treated with amoxicillin or trimethoprim-sulfadiazine (TMS).
  • Historically, UTI treatment was recommended for 7-14 days; newer studies suggest 3-5 days could be sufficient.
  • Analgesics (NSAIDs) can be started while awaiting culture results, with antibiotics added if clinical signs persist or worsen.
  • In cases of pyelonephritis, start with a fluoroquinolone for high tissue penetration.

Subclinical Bactiuria

  • Characterized by bacteria in sediment but no clinical symptoms.
  • Does not require treatment.

Case Study 2: Zombie

  • A 4-year-old male castrated domestic shorthair cat.
  • Diagnosed with a 3 day history of inappropriate urination, stranguria, periuria, and pollakiuria.
  • A new kitten had been introduced to the house.
  • Differential diagnoses considered were behavioral and medical (lower UTI, urolithiasis, urethritis, partial obstruction, or FIC).

PE and Diagnostics for Zombie

  • PE shows a small, painful, thickened bladder.
  • Has gross hematuria on the table.
  • TPR is WNL.
  • Resting findings on PE are WNL
  • Lab results include WBC +++ on dipstick, WBC 0-5 phf, RBC TNTC, struvite crystalluria, and culture pending on UA.

Urine Sediment Analysis

  • Analyzed to check for crystals

Struvite Crystalluria

  • Can be seen transiently.
  • Can form in sterile urine.
  • Can form secondary to urinary tract infections
  • Struvite stones may not dissolve completely unless treated with antibiotics if a UTI is present.
  • Treatment continues until the crystals have dissolved.

Additional Consideration

  • A list of conditions to consider include urolithiasis, septicemia, acute pyelonephritis, kidney failure, chronic pyelonephritis, and urethral strictures.

Zombie Outcome

  • Zombie does not need antibiotics because he most likely has Feline Idiopathic Cystitis (FIC).
  • FIC results from stress-induced.
  • Pain medication, SQ fluids, anti-anxiety medication, and a therapeutic diet are required.
  • Culture results have no growth.

Brownian Motion

  • It refers to the random movement displayed by small particles that are suspended in fluids.
  • It results from collisions of particles.

Case Study 3: Midnight

  • An 18.5yr old female spayed cat.
  • Has a history of CKD (stage 2) and systemic hypertension.
  • Appetite has started to diminish and the customer is reporting sever inappetence.

PE Findings

  • Body Condition Score (BCS) is 2/9 (4-5 is ideal).
  • Muscle condition score is moderate to severe generalized muscle loss.
  • Right and Left Kidneys are small, irregularly shaped and painful on palpation.
  • Dehydration (8%) with mild-moderate constipation.

Case Study 4: Felix

  • A 4-month-old male DSH that was adopted 3 days prior.
  • Serous nasal and ocular discharge.
  • Experiencing Sneezing.
  • Maybe has a mild decrease in appetite.
  • Still likes to play
  • TPR is WNL
  • Resting PE results are unremarkable

Case Study 5: Frankie

  • A 5-year-old female spayed Chesapeake Bay Retriever
  • Has 3-day history of large bowel diarrhea
  • Vomited one 3 days ago and once this morning
  • There is slight decrease in appetite
  • The owner states Frankie is not acting herself
  • Frankie got into the trash 4 days ago
  • She gets on Heartgard Plus
  • It's noted in the physical exam that it is hard to get the blood results with the way she is acting.

Case Study 6: Shakespeare

  • An 8-year-old male castrated DSH that goes Indoors/outdoors
  • Noted in the month of May
  • Lethargic, inappetance past 1-2 days
  • Fever 104.7
  • A small, ulcerative lesion is just below the lower left mandibular P4 and ulcers on the edge of the tongue

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