Podcast
Questions and Answers
Which of the following sensory modalities includes the perception of pain?
Which of the following sensory modalities includes the perception of pain?
- Proprioceptive sensations
- Thermal sensations
- Equilibrium
- Somatic sensory modalities (correct)
What is the function of visceral senses?
What is the function of visceral senses?
- They provide information about conditions within internal organs. (correct)
- They detect external stimuli like light and sound.
- They measure body temperature and pain.
- They allow perception of joint movements.
Which sensory receptor process involves converting energy from a stimulus into a graded potential?
Which sensory receptor process involves converting energy from a stimulus into a graded potential?
- Sensory adaptation
- Transmission of the signal
- Stimulation of the sensory receptor
- Transduction of the stimulus (correct)
Which type of sensation does NOT belong to the general senses?
Which type of sensation does NOT belong to the general senses?
What allows proprioceptive sensations to provide information about body position and movement?
What allows proprioceptive sensations to provide information about body position and movement?
What characterizes an electrical synapse?
What characterizes an electrical synapse?
Which of the following cells can serve as target cells in synaptic connections?
Which of the following cells can serve as target cells in synaptic connections?
How do electrical synapses compare to chemical synapses in terms of speed?
How do electrical synapses compare to chemical synapses in terms of speed?
What is the primary structural difference between chemical and electrical synapses?
What is the primary structural difference between chemical and electrical synapses?
Which statement about synapses is correct?
Which statement about synapses is correct?
What type of sensory receptor adapts slowly to a stimulus and continues to transmit signals?
What type of sensory receptor adapts slowly to a stimulus and continues to transmit signals?
Which of the following statements accurately describes phasic receptors?
Which of the following statements accurately describes phasic receptors?
What happens to sensory receptors during adaptation?
What happens to sensory receptors during adaptation?
Which receptor type is known for not adapting to stimuli?
Which receptor type is known for not adapting to stimuli?
Which of the following examples correctly illustrates rapid adaptation in sensory receptors?
Which of the following examples correctly illustrates rapid adaptation in sensory receptors?
What type of sensory neurons carry impulses from the peripheral nervous system into the central nervous system?
What type of sensory neurons carry impulses from the peripheral nervous system into the central nervous system?
Which type of receptor is primarily responsible for detecting mechanical stress such as pressure and vibration?
Which type of receptor is primarily responsible for detecting mechanical stress such as pressure and vibration?
What happens when graded potentials in sensory neurons reach the threshold level?
What happens when graded potentials in sensory neurons reach the threshold level?
Which type of receptors lack structural specialization and are responsible for detecting pain and temperature?
Which type of receptors lack structural specialization and are responsible for detecting pain and temperature?
Which statement regarding the integration of sensory input is correct?
Which statement regarding the integration of sensory input is correct?
What is the primary role of nociceptors in the human body?
What is the primary role of nociceptors in the human body?
What type of receptors are responsible for detecting light and are found in the retina?
What type of receptors are responsible for detecting light and are found in the retina?
What phenomenon occurs when initial pain stimuli lead to increased sensitivity to further painful stimuli?
What phenomenon occurs when initial pain stimuli lead to increased sensitivity to further painful stimuli?
Which type of response illustrates the inhibition of pain transmission through descending pathways?
Which type of response illustrates the inhibition of pain transmission through descending pathways?
Which receptor type detects changes in temperature and has two distinct types for hot and cold stimuli?
Which receptor type detects changes in temperature and has two distinct types for hot and cold stimuli?
Which classification of receptors responds primarily to external stimuli like touch and temperature?
Which classification of receptors responds primarily to external stimuli like touch and temperature?
What characterizes encapsulated nerve endings compared to free nerve endings?
What characterizes encapsulated nerve endings compared to free nerve endings?
What type of sensory receptor is responsible for responding to electromagnetic waves?
What type of sensory receptor is responsible for responding to electromagnetic waves?
What type of neurotransmitter is classified as an endorphin?
What type of neurotransmitter is classified as an endorphin?
Which receptor does morphine primarily act on?
Which receptor does morphine primarily act on?
How does cocaine affect dopamine in the synaptic cleft?
How does cocaine affect dopamine in the synaptic cleft?
What is the primary effect of nerve gas (Sarin) on neurotransmission?
What is the primary effect of nerve gas (Sarin) on neurotransmission?
What autoimmune condition is characterized by antibodies that antagonistically affect acetylcholine receptors?
What autoimmune condition is characterized by antibodies that antagonistically affect acetylcholine receptors?
Which component is NOT considered a basic constituent of neural circuits?
Which component is NOT considered a basic constituent of neural circuits?
What type of neurotransmission is primarily implicated in epilepsy?
What type of neurotransmission is primarily implicated in epilepsy?
What structure provides the primary location for synaptic connectivity?
What structure provides the primary location for synaptic connectivity?
Which of the following is an example of a neuronal pool?
Which of the following is an example of a neuronal pool?
In the myotatic reflex, sensory neurons transmit information in which direction?
In the myotatic reflex, sensory neurons transmit information in which direction?
Which psychiatric condition is linked with low levels of serotonin?
Which psychiatric condition is linked with low levels of serotonin?
What term describes neurons that only participate in local aspects of a circuit?
What term describes neurons that only participate in local aspects of a circuit?
What is the effect of cold on endorphin levels?
What is the effect of cold on endorphin levels?
What is one function of endorphins?
What is one function of endorphins?
What is the primary role of neurotransmitters at synapses?
What is the primary role of neurotransmitters at synapses?
What determines the amplitude of an excitatory postsynaptic potential (EPSP)?
What determines the amplitude of an excitatory postsynaptic potential (EPSP)?
How do inhibitory neurotransmitters affect the postsynaptic cell?
How do inhibitory neurotransmitters affect the postsynaptic cell?
What is the primary excitatory neurotransmitter in the central nervous system (CNS)?
What is the primary excitatory neurotransmitter in the central nervous system (CNS)?
What enzyme is responsible for degrading serotonin in the synaptic cleft?
What enzyme is responsible for degrading serotonin in the synaptic cleft?
Which neurotransmitter is primarily involved in muscle contraction?
Which neurotransmitter is primarily involved in muscle contraction?
What happens to the membrane potential when excitatory neurotransmitters bind to their receptors?
What happens to the membrane potential when excitatory neurotransmitters bind to their receptors?
Which of the following is NOT an example of an inhibitory neurotransmitter?
Which of the following is NOT an example of an inhibitory neurotransmitter?
How do modulating neurotransmitters differ from fast-acting neurotransmitters?
How do modulating neurotransmitters differ from fast-acting neurotransmitters?
Which neurotransmitter is synthesized from the amino acid tryptophan?
Which neurotransmitter is synthesized from the amino acid tryptophan?
What is the function of the receptor channels in nerve synapses?
What is the function of the receptor channels in nerve synapses?
What role does vitamin B6 play in serotonin production?
What role does vitamin B6 play in serotonin production?
Which of the following neurotransmitters can act both as a neurotransmitter and a modulator?
Which of the following neurotransmitters can act both as a neurotransmitter and a modulator?
How is the action potential concluded at the presynaptic cell?
How is the action potential concluded at the presynaptic cell?
What is divergence in neuronal pools?
What is divergence in neuronal pools?
How does convergence affect motor neurons?
How does convergence affect motor neurons?
What characterizes serial processing in neurons?
What characterizes serial processing in neurons?
What does parallel processing allow in the context of sensory information?
What does parallel processing allow in the context of sensory information?
What is reverberation in a neural circuit?
What is reverberation in a neural circuit?
Which of the following best defines sensation?
Which of the following best defines sensation?
What distinguishes perception from sensation?
What distinguishes perception from sensation?
Which of the following is NOT a characteristic of divergence?
Which of the following is NOT a characteristic of divergence?
What can occur when sensory impulses reach the spinal cord?
What can occur when sensory impulses reach the spinal cord?
Which pattern of interaction among neurons allows for the same inputs to produce different outputs?
Which pattern of interaction among neurons allows for the same inputs to produce different outputs?
In which situation is serial processing primarily observed?
In which situation is serial processing primarily observed?
What type of feedback is involved in maintaining normal breathing according to reverberation?
What type of feedback is involved in maintaining normal breathing according to reverberation?
What is NOT a sensory modality?
What is NOT a sensory modality?
What mechanism allows a sharp stimulus to produce multiple simultaneous reactions?
What mechanism allows a sharp stimulus to produce multiple simultaneous reactions?
Which of the following best describes the relationship between sensation and perception?
Which of the following best describes the relationship between sensation and perception?
Flashcards
Synapse
Synapse
The point where a nerve cell (neuron) communicates with another cell.
What does a synapse connect to?
What does a synapse connect to?
Nerve cells, muscle cells, or glands.
Electrical Synapse
Electrical Synapse
A type of synapse where the membranes of two cells are tightly connected, allowing nerve impulses to pass quickly and reliably.
Chemical Synapse
Chemical Synapse
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What is special about electrical synapses vs. chemical synapses?
What is special about electrical synapses vs. chemical synapses?
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Sensation
Sensation
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Sensory Receptors
Sensory Receptors
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Transduction
Transduction
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Somatic Senses
Somatic Senses
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Visceral Senses
Visceral Senses
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Proprioceptors
Proprioceptors
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Adaptation
Adaptation
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Tonic Receptor
Tonic Receptor
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Phasic Receptor
Phasic Receptor
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Rapidly Adapting Receptors
Rapidly Adapting Receptors
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Synaptic Transmission
Synaptic Transmission
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Neurotransmitter Release Regulation
Neurotransmitter Release Regulation
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Neurotransmitter
Neurotransmitter
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Neurotransmitter Receptor
Neurotransmitter Receptor
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Ionotropic Receptor
Ionotropic Receptor
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Receptor Activation
Receptor Activation
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Excitatory Post-Synaptic Potential (EPSP)
Excitatory Post-Synaptic Potential (EPSP)
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Inhibitory Post-Synaptic Potential (IPSP)
Inhibitory Post-Synaptic Potential (IPSP)
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Glutamate
Glutamate
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Acetylcholine
Acetylcholine
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Glycine
Glycine
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Gamma Aminobutyric Acid (GABA)
Gamma Aminobutyric Acid (GABA)
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Serotonin (5-HT)
Serotonin (5-HT)
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Monoamine Oxidase (MAO)
Monoamine Oxidase (MAO)
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Modulator (e.g., Serotonin, Dopamine)
Modulator (e.g., Serotonin, Dopamine)
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What are endorphins?
What are endorphins?
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How do endorphins work?
How do endorphins work?
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What increases endorphin levels?
What increases endorphin levels?
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How does nicotine affect the brain?
How does nicotine affect the brain?
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How does curare work?
How does curare work?
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What are the effects of morphine and heroin?
What are the effects of morphine and heroin?
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How does cannabis affect the brain?
How does cannabis affect the brain?
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How does cocaine work?
How does cocaine work?
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How does sarin work?
How does sarin work?
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What is Myasthenia Gravis?
What is Myasthenia Gravis?
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What is Graves' disease?
What is Graves' disease?
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How is epilepsy linked to synapses?
How is epilepsy linked to synapses?
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How are depression and schizophrenia related to synapses?
How are depression and schizophrenia related to synapses?
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What are neuronal pools?
What are neuronal pools?
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What is a neuropil?
What is a neuropil?
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Neuronal pool
Neuronal pool
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Neural circuit
Neural circuit
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Divergence
Divergence
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Convergence
Convergence
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Serial processing
Serial processing
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Parallel processing
Parallel processing
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Reverberating circuit
Reverberating circuit
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Perception
Perception
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Sensory modality
Sensory modality
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Spinal reflex
Spinal reflex
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Brain stem reflex
Brain stem reflex
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Cerebral cortex sensation
Cerebral cortex sensation
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Sensory transduction
Sensory transduction
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Olfactory Receptor Signal Transduction
Olfactory Receptor Signal Transduction
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Graded Potentials
Graded Potentials
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First Order Neurons (1Ëš)
First Order Neurons (1Ëš)
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Sensory Integration by the CNS
Sensory Integration by the CNS
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Free Nerve Endings
Free Nerve Endings
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Encapsulated Nerve Endings
Encapsulated Nerve Endings
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Separate Sensory Cells
Separate Sensory Cells
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Mechanoreceptors
Mechanoreceptors
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Thermoreceptors
Thermoreceptors
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Nociceptors
Nociceptors
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Chemoreceptors
Chemoreceptors
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Photoreceptors
Photoreceptors
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Generator Potential
Generator Potential
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Receptor Potential
Receptor Potential
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Exteroceptors
Exteroceptors
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Study Notes
Synapses
- Synapses are specialized junctions where neurons communicate with target cells.
- Target cells include nerves, muscles, and glands.
- Two types of synapses: electrical and chemical.
Electrical Synapses
- Rare in vertebrates.
- Membranes of the two cells are in close contact, creating electrical coupling.
- Enables fast and reliable transmission of nerve impulses (action potentials).
- Faster than chemical synapses.
- More synchronized.
Chemical Synapses
- More common.
- Presynaptic and postsynaptic cells are separated by a synaptic cleft (10-15 times wider than electrical synapses).
- Transmission relies on neurotransmitters released from the presynaptic cell.
- Allows for precise control of neurotransmitter release.
Neurotransmitters
- Neurotransmitters and their receptors have a lock-and-key fit.
- At nerve-muscle and many nerve-nerve synapses, receptors act as ion channels.
- Binding of a neurotransmitter changes the receptor shape, opening an intrinsic pore.
Excitatory Postsynaptic Potentials (EPSPs)
- Excitatory neurotransmitters open ion channels allowing positively charged sodium ions to enter the cell.
- This depolarizes the postsynaptic membrane, creating an EPSP.
- EPSP amplitude is roughly proportional to the number of released vesicles.
- Sufficiently large EPSPs trigger an action potential in the target cell.
Inhibitory Transmitters
- Inhibitory neurotransmitters make the postsynaptic cell less excitable.
- Often associated with chloride or potassium channels, leading to hyperpolarization (making the interior more negative).
- Examples include glycine and GABA.
Acetylcholine and Glutamate
- Acetylcholine is excitatory at nerve-skeletal muscle synapses.
- Glutamate is the main excitatory neurotransmitter in the central nervous system.
Serotonin (5-hydroxytryptamine, 5-HT)
- Synthesized from tryptophan, with vitamin B6 aiding the process.
- Predominantly found in the gut.
- Stored in vesicles in the presynaptic terminals.
- Action potential triggers exocytosis of serotonin into the synaptic cleft.
- Serotonin binds to receptors on the postsynaptic cell, depolarizing it.
- Reaching threshold initiates an action potential in the postsynaptic cell.
- Remaining serotonin is degraded by monoamine oxidase (MAO).
- MAO also degrades reabsorbed serotonin, terminating nerve signals and preparing the synapse for subsequent impulses.
- Catechol-O-methyl transferase (COMT) targets catecholamines (not serotonin).
- MAOIs are antidepressants.
- Serotonin can act as a modulator.
Modulation
- Slower and longer-lasting than fast neurotransmitters.
- Often involve activation of intracellular messengers (not directly opening ion channels).
- Can affect gene expression.
- Multiple neurotransmitters/modulators can be released by a single nerve terminal.
Enkephalins (Opiates/Endorphins)
- Neuropeptide.
- Inhibitory effect.
- Located in the brain and spinal cord.
- Functions: stress reduction, promoting calmness, natural pain killer.
- Cold and exercise likely increase endorphin production.
Synapse Abuse
- Many drugs affect synapses.
- Nicotine activates nicotinic acetylcholine receptors, causing dopamine release.
- Curare is an antagonist of acetylcholine receptors, blocking neuromuscular transmission.
- Morphine/Heroin act on opiate receptors.
- Cannabis acts on cannabinoid receptors.
- Cocaine blocks dopamine reuptake (prolonged dopamine in the cleft).
- Nerve gas (Sarin) blocks acetylcholine removal, causing spastic paralysis.
Disorders of Synaptic Function
- Myasthenia Gravis: Autoantibodies antagonize acetylcholine receptors, leading to reduced neurotransmission and fatigue.
- Graves Disease: Autoantibodies agonistically bind to the thyroid gland.
- Epilepsy: Possibly linked to decreased inhibitory transmission (GABA).
- Depression/Schizophrenia: Likely involve serotonin/dopamine synapse disruptions.
Neural Circuits
- Neurons function in ensembles.
- Synaptic connections form a neuropil, a dense network between cell bodies, where most connections occur.
- Afferent neurons carry information to the CNS.
- Efferent neurons carry information away from the CNS.
- Interneurons participate in local circuits.
- Example: stretch reflex circuit (sensory afferents, interneurons, motor efferents).
Neuronal Pools
- Groups of interconnected neurons with specific functions.
- Defined functionally, not anatomically.
- Five circuit patterns: divergence, convergence, serial processing, parallel processing, reverberation.
Sensation
- Conscious/unconscious awareness of stimuli.
- Nature of sensation depends on impulse destination and receptor type.
- Can range from simple reflexes to complex perceptions.
Sensation vs. Perception
- Sensation: Awareness of any stimulus detected by receptors.
- Perception: Conscious awareness and interpretation of a sensation.
Sensory Modality
- Property differentiating one sensation from another.
- General senses (somatic & visceral) and special senses (smell, taste, vision, hearing, equilibrium).
General Senses
- Somatic senses: tactile (touch, pressure, vibration, itch), thermal (temperature), pain, proprioceptive (joint/muscle position).
- Visceral senses: Conditions within internal organs (e.g., pressure, pain).
Special Senses
- Smell, taste, vision, hearing, equilibrium (cranial nerves).
Process of Sensation
- 4 steps: stimulation of sensory receptor, transduction into a graded potential (generator or receptor potential), generation of impulses (action potentials), and integration by the CNS.
Sensory Receptors
- Range from simple to complex structures.
- Classified by structure, stimulus type, response to stimulus, and location.
Types of Receptors
- Free nerve endings: Bare dendrites (pain, temperature, itch, light touch).
- Encapsulated nerve endings: Dendrites in connective tissue capsules (pressure, vibration, deep touch).
- Separate sensory cells: Specialized cells that synapse onto neurons (vision, taste, hearing, equilibrium - except smell).
Stimulus Types of Receptors
- Mechanoreceptors: Detect physical or mechanical stress.
- Thermoreceptors: Detect temperature changes (hot/cold).
- Nociceptors: Detect potential tissue damage (intense mechanical deformation, excessive heat, chemicals).
- Chemoreceptors: Detect chemicals (taste, smell, blood oxygen, pH).
- Photoreceptors: Detect light (rods/cones).
- Other: Electromagnetic receptors, baroreceptors.
Hyperalgesia/Stimulation-produced analgesia
- Hyperalgesia: Increased sensitivity to pain after initial stimulus.
- Stimulation-produced analgesia: Descending pathways inhibiting pain signals; opioids involved.
- Referred pain: Pain felt at site different from actual injury location.
Pain-Gate Theory
- Stimulation of non-pain afferents can inhibit pain pathways (TENS).
Receptor Potential
- A graded potential in receptors in the special senses.
Receptor Location
- Exteroceptors: External stimuli.
- Interoceptors: Internal stimuli (e.g., blood pressure).
- Proprioceptors: Body position (muscles, tendons, joints).
Adaptation
- Most receptors adapt (decrease sensitivity to maintained stimuli).
- Tonic receptors: Adapt slowly, provide information about stimulus duration.
- Phasic receptors: Adapt rapidly, signal changes in stimulus intensity.
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