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Questions and Answers
What is the primary mechanism of action for the drugs discussed in the content?
What is the primary mechanism of action for the drugs discussed in the content?
Which of the following is a contraindication for the use of sulfasalazine?
Which of the following is a contraindication for the use of sulfasalazine?
What should be monitored in a patient taking the medication discussed?
What should be monitored in a patient taking the medication discussed?
What should be the method of administration for retention enemas?
What should be the method of administration for retention enemas?
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Which of the following is a possible adverse effect to monitor for with the medication?
Which of the following is a possible adverse effect to monitor for with the medication?
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What is the correct procedure for administering the medication discussed?
What is the correct procedure for administering the medication discussed?
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Why is it important to follow a tapering dose with this medication?
Why is it important to follow a tapering dose with this medication?
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Which symptom is not a common sign to monitor for while on this medication?
Which symptom is not a common sign to monitor for while on this medication?
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What condition's development must be monitored in patients taking this medication?
What condition's development must be monitored in patients taking this medication?
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What is the main site of action for the time-release form of this medication?
What is the main site of action for the time-release form of this medication?
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Study Notes
Sulfasalazine Action
- Sulfasalazine inhibits leukotrienes and tumor necrosis factor in the intestines.
- The drug is metabolized by bacteria in the intestines to an active form that acts locally.
- Sulfasalazine is administered orally, as an enema, or as a suppository.
Sulfasalazine Administration
- Administer oral forms of sulfasalazine with 8 oz of water.
- Administer suppositories or retention enemas at bedtime.
Sulfasalazine Contraindications
- Hypersensitivity to sulfonamides or salicylates.
- Intestinal or urinary tract obstruction.
Sulfasalazine Potential Interactions
- Potential adverse effect in patients taking heparin.
Sulfasalazine Monitoring
- Assess baseline renal function tests, liver function tests, and complete blood count (CBC).
- Evaluate for therapeutic response including reduced number of stools, reduced mucus and blood, and improved stool consistency.
- Monitor for possible adverse effects including headache, diarrhea, dizziness, rhinitis, sinusitis, or skin rash and pruritus.
Administration
- Administer orally as a time-release drug that dissolves in the ileum and colon
- Can be administered as an enema for topical action
Dosage
- Follow tapering dose, as ordered by the provider.
Monitoring
- Monitor for signs of headache, acne, infections, and the development of Cushing disease.
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Description
Explore the key aspects of sulfasalazine, including its action mechanism, various administration methods, contraindications, and monitoring protocols. This quiz provides insights into the importance of proper administration and potential interactions of this medication.
