Pharmacology: Adverse Effects of Sulfasalazine
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Questions and Answers

What is the primary region affected by Ulcerative Colitis?

  • Esophagus
  • Stomach
  • Small intestine
  • Large intestine (correct)

    • What is a common symptom of Ulcerative Colitis?

  • Hiccups
  • Nausea and vomiting
  • Rectal bleeding (correct)
  • Dry mouth

    • What is a potential complication of Ulcerative Colitis due to malabsorption of water and electrolytes?

  • Gingivitis and periodontitis
  • Dehydration and fatigue (correct)
  • Arthritis and eye disorders
  • Hypertension and diabetes

    • What is the approximate percentage of patients with Ulcerative Colitis who remain symptom-free over a 10-year period?

    <p>Less than 5%</p> Signup and view all the answers

    What is a potential extraintestinal manifestation of Ulcerative Colitis?

    <p>Arthritis</p> Signup and view all the answers

    What is the approximate percentage of patients with Ulcerative Colitis who experience a relapse in any given year?

    <p>50%</p> Signup and view all the answers

    What is a possible oral manifestation of toxic effects on bone marrow due to sulfasalazine use?

    <p>Bald tongue</p> Signup and view all the answers

    Which of the following antibiotics is most commonly associated with an increased risk of pseudomembranous colitis?

    <p>Clindamycin</p> Signup and view all the answers

    What is the most common presenting manifestation of pseudomembranous colitis?

    <p>Diarrhea</p> Signup and view all the answers

    When is the highest risk of developing pseudomembranous colitis?

    <p>When antibiotics are used in hospitals or farmyards</p> Signup and view all the answers

    What is the typical timing of diarrhea onset after antibiotic administration?

    <p>1-10 days after administration</p> Signup and view all the answers

    What is a severe complication of pseudomembranous colitis?

    <p>Death</p> Signup and view all the answers

    What is a complication of ulcerative colitis?

    <p>Adenocarcinoma of the colon</p> Signup and view all the answers

    What is a characteristic of Crohn's disease?

    <p>Segmental distribution of intestinal ulcers</p> Signup and view all the answers

    What is a feature of chronic Crohn's disease?

    <p>Nodular or 'cobblestone' appearance of the intestinal mucosa</p> Signup and view all the answers

    What is a common initial manifestation of Crohn's disease?

    <p>Recurrent or persistent diarrhea</p> Signup and view all the answers

    What is a complication of toxic megacolon?

    <p>Intestinal perforation</p> Signup and view all the answers

    What is associated with Crohn's disease?

    <p>Noncaseating epithelioid granulomas</p> Signup and view all the answers

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