Pharmacology: Adverse Effects of Sulfasalazine
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Questions and Answers

What is the primary region affected by Ulcerative Colitis?

  • Esophagus
  • Stomach
  • Small intestine
  • Large intestine (correct)

What is a common symptom of Ulcerative Colitis?

  • Hiccups
  • Nausea and vomiting
  • Rectal bleeding (correct)
  • Dry mouth

What is a potential complication of Ulcerative Colitis due to malabsorption of water and electrolytes?

  • Gingivitis and periodontitis
  • Dehydration and fatigue (correct)
  • Arthritis and eye disorders
  • Hypertension and diabetes

What is the approximate percentage of patients with Ulcerative Colitis who remain symptom-free over a 10-year period?

<p>Less than 5% (D)</p> Signup and view all the answers

What is a potential extraintestinal manifestation of Ulcerative Colitis?

<p>Arthritis (C)</p> Signup and view all the answers

What is the approximate percentage of patients with Ulcerative Colitis who experience a relapse in any given year?

<p>50% (B)</p> Signup and view all the answers

What is a possible oral manifestation of toxic effects on bone marrow due to sulfasalazine use?

<p>Bald tongue (B)</p> Signup and view all the answers

Which of the following antibiotics is most commonly associated with an increased risk of pseudomembranous colitis?

<p>Clindamycin (C)</p> Signup and view all the answers

What is the most common presenting manifestation of pseudomembranous colitis?

<p>Diarrhea (D)</p> Signup and view all the answers

When is the highest risk of developing pseudomembranous colitis?

<p>When antibiotics are used in hospitals or farmyards (C)</p> Signup and view all the answers

What is the typical timing of diarrhea onset after antibiotic administration?

<p>1-10 days after administration (C)</p> Signup and view all the answers

What is a severe complication of pseudomembranous colitis?

<p>Death (B)</p> Signup and view all the answers

What is a complication of ulcerative colitis?

<p>Adenocarcinoma of the colon (D)</p> Signup and view all the answers

What is a characteristic of Crohn's disease?

<p>Segmental distribution of intestinal ulcers (D)</p> Signup and view all the answers

What is a feature of chronic Crohn's disease?

<p>Nodular or 'cobblestone' appearance of the intestinal mucosa (D)</p> Signup and view all the answers

What is a common initial manifestation of Crohn's disease?

<p>Recurrent or persistent diarrhea (B)</p> Signup and view all the answers

What is a complication of toxic megacolon?

<p>Intestinal perforation (B)</p> Signup and view all the answers

What is associated with Crohn's disease?

<p>Noncaseating epithelioid granulomas (B)</p> Signup and view all the answers

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