Pharmacology: Adverse Effects of Sulfasalazine

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18 Questions

What is the primary region affected by Ulcerative Colitis?

Large intestine

What is a common symptom of Ulcerative Colitis?

Rectal bleeding

What is a potential complication of Ulcerative Colitis due to malabsorption of water and electrolytes?

Dehydration and fatigue

What is the approximate percentage of patients with Ulcerative Colitis who remain symptom-free over a 10-year period?

Less than 5%

What is a potential extraintestinal manifestation of Ulcerative Colitis?

Arthritis

What is the approximate percentage of patients with Ulcerative Colitis who experience a relapse in any given year?

50%

What is a possible oral manifestation of toxic effects on bone marrow due to sulfasalazine use?

Bald tongue

Which of the following antibiotics is most commonly associated with an increased risk of pseudomembranous colitis?

Clindamycin

What is the most common presenting manifestation of pseudomembranous colitis?

Diarrhea

When is the highest risk of developing pseudomembranous colitis?

When antibiotics are used in hospitals or farmyards

What is the typical timing of diarrhea onset after antibiotic administration?

1-10 days after administration

What is a severe complication of pseudomembranous colitis?

Death

What is a complication of ulcerative colitis?

Adenocarcinoma of the colon

What is a characteristic of Crohn's disease?

Segmental distribution of intestinal ulcers

What is a feature of chronic Crohn's disease?

Nodular or 'cobblestone' appearance of the intestinal mucosa

What is a common initial manifestation of Crohn's disease?

Recurrent or persistent diarrhea

What is a complication of toxic megacolon?

Intestinal perforation

What is associated with Crohn's disease?

Noncaseating epithelioid granulomas

Learn about the toxic effects of sulfasalazine on bone marrow, including anemia, agranulocytosis, and thrombocytopenia. Also, understand the risks and symptoms of Pseudomembranous colitis, a severe form of colitis caused by Clostridium difficile overgrowth.

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