Subcutaneous Biosimilar Infliximab Quiz
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Questions and Answers

What is the mechanism of action of Vedolizumab?

  • Targets the cellular adhesion molecule α4-integrin
  • Inhibits signaling through TNFα receptors
  • Binds to soluble TNF-α
  • Blocks the entry of lymphocytes into mucosal tissues (correct)

What adverse effect is NOT commonly associated with Vedolizumab?

  • Blurred vision and dizziness
  • Fast, pounding heartbeat (correct)
  • Joint pain and headache
  • Yellow skin or eyes

Which biologic agent targets the cellular adhesion molecule α4-integrin?

  • Vedolizumab
  • Natalizumab (correct)
  • Adalimumab
  • Certolizumab pegol

What serious risk is associated with Natalizumab?

<p>Progressive multifocal leukoencephalopathy (B)</p> Signup and view all the answers

How does Certolizumab pegol inhibit TNF-α?

<p>By binding to soluble TNF-α (C)</p> Signup and view all the answers

What is the mechanism of action of Vedolizumab in the treatment of inflammatory bowel disease (IBD)?

<p>Prevents lymphocytes from egressing from lymphoid organs (B)</p> Signup and view all the answers

Which adverse effect is NOT commonly associated with Natalizumab therapy?

<p>Joint pain (D)</p> Signup and view all the answers

Which enzyme is involved in the metabolism of Etrasimod, one of the new treatments for IBD?

<p>CYP3A4 (B)</p> Signup and view all the answers

What type of monoclonal antibody is Mirikizumab, another new treatment for IBD?

<p>IgG4 (B)</p> Signup and view all the answers

Which biologic agent is known for binding to the S1P-receptor and preventing lymphocytes from egressing from lymphoid organs?

<p>Vedolizumab (D)</p> Signup and view all the answers

What distinguishes the delivery of the biosimilar of infliximab from the original drug?

<p>It is delivered subcutaneously (D)</p> Signup and view all the answers

Which of the following is NOT a possible side effect of the biosimilar of infliximab according to the text?

<p>Changes in taste perception (B)</p> Signup and view all the answers

What distinguishes Adalimumab from infliximab in terms of its structure?

<p>Adalimumab is fully humanized (A)</p> Signup and view all the answers

Which cytokine do biologic agents like Adalimumab and infliximab target?

<p>TNF-α (D)</p> Signup and view all the answers

Among the listed possible side effects, which one warrants immediate medical attention?

<p>Warm, red, swollen, or painful skin (D)</p> Signup and view all the answers

Which enzyme is responsible for the metabolism of thiopurine methyltransferase (TPMT) to 6-methyl-mercaptopurine (6-MMP)?

<p>Hypoxanthine–guanine phosphoribosyl transferase (HGPRT) (B)</p> Signup and view all the answers

Which biologic agent for IBD acts by blocking the p19 subunit of interleukin-23?

<p>Risankizumab-rzaa (D)</p> Signup and view all the answers

What is a potential adverse effect associated with vedolizumab?

<p>Swelling of the face and throat (C)</p> Signup and view all the answers

What is the primary mode of action of Infliximab, a biologic agent that targets TNF-α?

<p>Binds TNF-α and inhibits its inflammatory effects (A)</p> Signup and view all the answers

Which biologic agent is a TNF-α inhibitor used in the treatment of IBD?

<p>Adalimumab (C)</p> Signup and view all the answers

What is the main function of Vedolizumab in the treatment of inflammatory bowel disease (IBD)?

<p>Blocks lymphocyte trafficking into the gut (B)</p> Signup and view all the answers

What is a possible adverse effect associated with Infliximab?

<p>Loss of response over time (D)</p> Signup and view all the answers

What is a common adverse effect associated with natalizumab?

<p>Increased risk of infections (B)</p> Signup and view all the answers

Which biologic agent for IBD interacts with the IL-23 receptor to prevent its action?

<p>Ustekinumab (C)</p> Signup and view all the answers

Which biologic agent targets TNF-α and has been FDA approved around 2023?

<p>Infliximab (A)</p> Signup and view all the answers

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