Subcutaneous Biosimilar Infliximab Quiz

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What is the mechanism of action of Vedolizumab?

Targets the cellular adhesion molecule α4-integrin

Inhibits signaling through TNFα receptors

Binds to soluble TNF-α

Blocks the entry of lymphocytes into mucosal tissues (correct)

What adverse effect is NOT commonly associated with Vedolizumab?

Blurred vision and dizziness

Fast, pounding heartbeat (correct)

Joint pain and headache

Yellow skin or eyes

Which biologic agent targets the cellular adhesion molecule α4-integrin?

Vedolizumab

Natalizumab (correct)

Adalimumab

Certolizumab pegol

What serious risk is associated with Natalizumab?

Progressive multifocal leukoencephalopathy Signup and view all the answers

How does Certolizumab pegol inhibit TNF-α?

By binding to soluble TNF-α Signup and view all the answers

What is the mechanism of action of Vedolizumab in the treatment of inflammatory bowel disease (IBD)?

Prevents lymphocytes from egressing from lymphoid organs Signup and view all the answers

Which adverse effect is NOT commonly associated with Natalizumab therapy?

Joint pain Signup and view all the answers

Which enzyme is involved in the metabolism of Etrasimod, one of the new treatments for IBD?

CYP3A4 Signup and view all the answers

What type of monoclonal antibody is Mirikizumab, another new treatment for IBD?

IgG4 Signup and view all the answers

Which biologic agent is known for binding to the S1P-receptor and preventing lymphocytes from egressing from lymphoid organs?

Vedolizumab Signup and view all the answers

What distinguishes the delivery of the biosimilar of infliximab from the original drug?

It is delivered subcutaneously Signup and view all the answers

Which of the following is NOT a possible side effect of the biosimilar of infliximab according to the text?

Changes in taste perception Signup and view all the answers

What distinguishes Adalimumab from infliximab in terms of its structure?

Adalimumab is fully humanized Signup and view all the answers

Which cytokine do biologic agents like Adalimumab and infliximab target?

TNF-α Signup and view all the answers

Among the listed possible side effects, which one warrants immediate medical attention?

Warm, red, swollen, or painful skin Signup and view all the answers

Which enzyme is responsible for the metabolism of thiopurine methyltransferase (TPMT) to 6-methyl-mercaptopurine (6-MMP)?

Hypoxanthine–guanine phosphoribosyl transferase (HGPRT) Signup and view all the answers

Which biologic agent for IBD acts by blocking the p19 subunit of interleukin-23?

Risankizumab-rzaa Signup and view all the answers

What is a potential adverse effect associated with vedolizumab?

Swelling of the face and throat Signup and view all the answers

What is the primary mode of action of Infliximab, a biologic agent that targets TNF-α?

Binds TNF-α and inhibits its inflammatory effects Signup and view all the answers

Which biologic agent is a TNF-α inhibitor used in the treatment of IBD?

Adalimumab Signup and view all the answers

What is the main function of Vedolizumab in the treatment of inflammatory bowel disease (IBD)?

Blocks lymphocyte trafficking into the gut Signup and view all the answers

What is a possible adverse effect associated with Infliximab?

Loss of response over time Signup and view all the answers

What is a common adverse effect associated with natalizumab?

Increased risk of infections Signup and view all the answers

Which biologic agent for IBD interacts with the IL-23 receptor to prevent its action?

Ustekinumab Signup and view all the answers

Which biologic agent targets TNF-α and has been FDA approved around 2023?

Infliximab Signup and view all the answers